6J1M
Anisodus acutangulus type III polyketide sythase AaPKS2 in complex with 4-carboxy-3-oxobutanoyl covalent to C166
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009710 | biological_process | tropane alkaloid biosynthetic process |
| A | 0009813 | biological_process | flavonoid biosynthetic process |
| A | 0016625 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0030639 | biological_process | polyketide biosynthetic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0009710 | biological_process | tropane alkaloid biosynthetic process |
| B | 0009813 | biological_process | flavonoid biosynthetic process |
| B | 0016625 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0030639 | biological_process | polyketide biosynthetic process |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue 6JN A 401 |
| Chain | Residue |
| A | ARG134 |
| A | GLY376 |
| A | PRO377 |
| A | HOH508 |
| A | GLY165 |
| A | CYS166 |
| A | PHE217 |
| A | LEU258 |
| A | HIS305 |
| A | GLY307 |
| A | ASN338 |
| A | SER340 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 402 |
| Chain | Residue |
| A | HIS259 |
| A | ARG261 |
| B | GLN97 |
| B | ASP138 |
| B | HOH550 |
| B | HOH610 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 403 |
| Chain | Residue |
| A | GLU16 |
| A | GLY17 |
| A | GLU181 |
| A | SER228 |
| A | HOH624 |
| A | HOH628 |
| B | ASN182 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 404 |
| Chain | Residue |
| A | LYS236 |
| A | PRO237 |
| A | ARG352 |
| A | THR363 |
| A | PRO390 |
| A | HOH557 |
| A | HOH612 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 402 |
| Chain | Residue |
| B | SER243 |
| B | ALA244 |
| B | ALA245 |
| B | ALA288 |
| B | THR383 |
| B | HOH570 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide 6JN B 401 and CYS B 166 |
| Chain | Residue |
| B | ARG134 |
| B | GLY165 |
| B | PHE167 |
| B | ALA168 |
| B | PHE217 |
| B | LEU258 |
| B | HIS305 |
| B | GLY307 |
| B | ASN338 |
| B | SER340 |
| B | PHE375 |
| B | GLY376 |
| B | PRO377 |
| B | HOH531 |
Functional Information from PROSITE/UniProt
| site_id | PS00441 |
| Number of Residues | 17 |
| Details | CHALCONE_SYNTH Chalcone and stilbene synthases active site. RLmMyQqGCFAGGTmLR |
| Chain | Residue | Details |
| A | ARG158-ARG174 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile; acyl-thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU10023","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"31492848","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J1M","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"31492848","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31492848","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J1N","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
