Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008171 | molecular_function | O-methyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0032259 | biological_process | methylation |
| A | 0044550 | biological_process | secondary metabolite biosynthetic process |
| A | 0046983 | molecular_function | protein dimerization activity |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0008171 | molecular_function | O-methyltransferase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0032259 | biological_process | methylation |
| B | 0044550 | biological_process | secondary metabolite biosynthetic process |
| B | 0046983 | molecular_function | protein dimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue SAM A 401 |
| Chain | Residue |
| A | GLY227 |
| A | ARG291 |
| A | LEU292 |
| A | HOH540 |
| A | HOH585 |
| A | HOH590 |
| A | HOH598 |
| A | HOH646 |
| A | HOH689 |
| A | HOH742 |
| A | HOH780 |
| A | GLY229 |
| A | HOH810 |
| A | ASP252 |
| A | LEU253 |
| A | VAL256 |
| A | HIS274 |
| A | ASN275 |
| A | PHE276 |
| A | HIS277 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | binding site for residue B0L A 402 |
| Chain | Residue |
| A | HIS133 |
| A | LEU138 |
| A | CYS175 |
| A | LEU192 |
| A | ASP195 |
| A | ARG295 |
| A | ASP296 |
| A | THR338 |
| A | CYS341 |
| A | ILE342 |
| A | ALA345 |
| A | LEU346 |
| A | EDO411 |
| A | HOH576 |
| B | PHE41 |
| B | MET45 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 403 |
| Chain | Residue |
| A | GLU90 |
| A | LEU91 |
| A | ARG94 |
| B | ASP156 |
| B | ILE157 |
| B | MET343 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 404 |
| Chain | Residue |
| A | LYS209 |
| A | ARG318 |
| A | HOH617 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 405 |
| Chain | Residue |
| A | ASP156 |
| A | ILE157 |
| A | MET343 |
| B | GLU90 |
| B | LEU91 |
| B | ARG94 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 406 |
| Chain | Residue |
| A | SER115 |
| A | SER116 |
| A | ASN117 |
| A | GLN120 |
| A | HOH700 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 407 |
| Chain | Residue |
| A | THR194 |
| A | ASP195 |
| A | GLU196 |
| A | HOH543 |
| A | HOH640 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 408 |
| Chain | Residue |
| A | PRO183 |
| A | THR184 |
| A | HOH501 |
| A | HOH504 |
| A | HOH871 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 409 |
| Chain | Residue |
| A | GLY284 |
| A | PRO311 |
| A | ALA312 |
| A | MET313 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 410 |
| Chain | Residue |
| A | GLN258 |
| A | GLN261 |
| A | SER271 |
| A | HOH545 |
| A | HOH801 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 411 |
| Chain | Residue |
| A | HIS133 |
| A | B0L402 |
| A | HOH511 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue CL A 412 |
| Chain | Residue |
| A | LYS329 |
| A | GLY330 |
| A | ALA331 |
| B | ARG97 |
| B | GLN107 |
| B | HOH614 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue CL A 413 |
| Chain | Residue |
| A | TYR241 |
| A | PRO242 |
| A | ASN243 |
| A | GLN244 |
| B | THR278 |
| B | PRO279 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 415 |
| Chain | Residue |
| A | THR198 |
| A | HOH616 |
| A | HOH846 |
| site_id | AD6 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 416 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 417 |
| Chain | Residue |
| B | ARG23 |
| A | SER36 |
| A | LEU37 |
| A | GLU38 |
| A | THR39 |
| A | PRO40 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 418 |
| Chain | Residue |
| A | PRO298 |
| A | ASP299 |
| A | HOH635 |
| A | HOH723 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue IMD A 419 |
| Chain | Residue |
| A | LEU202 |
| A | SER203 |
| A | THR204 |
| A | PHE205 |
| A | LYS240 |
| A | TYR241 |
| site_id | AE1 |
| Number of Residues | 21 |
| Details | binding site for residue SAM B 401 |
| Chain | Residue |
| B | GLY227 |
| B | GLY228 |
| B | GLY229 |
| B | ASP252 |
| B | LEU253 |
| B | VAL256 |
| B | HIS274 |
| B | ASN275 |
| B | PHE276 |
| B | HIS277 |
| B | ARG291 |
| B | LEU292 |
| B | HOH557 |
| B | HOH593 |
| B | HOH600 |
| B | HOH657 |
| B | HOH662 |
| B | HOH710 |
| B | HOH714 |
| B | HOH732 |
| B | HOH795 |
| site_id | AE2 |
| Number of Residues | 14 |
| Details | binding site for residue B0L B 402 |
| Chain | Residue |
| A | PHE41 |
| A | MET45 |
| B | HIS133 |
| B | LEU138 |
| B | CYS175 |
| B | LEU192 |
| B | ARG295 |
| B | ASP296 |
| B | THR338 |
| B | CYS341 |
| B | ILE342 |
| B | ALA345 |
| B | LEU346 |
| B | HOH675 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 403 |
| Chain | Residue |
| B | LYS67 |
| B | PRO125 |
| B | HOH818 |
| site_id | AE4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 404 |
| Chain | Residue |
| B | SER115 |
| B | SER116 |
| B | ASN117 |
| B | GLN120 |
| B | HOH708 |
| site_id | AE5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 405 |
| Chain | Residue |
| B | ILE186 |
| B | HOH504 |
| B | HOH514 |
| B | HOH606 |
| B | HOH635 |
| B | HOH640 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 406 |
| Chain | Residue |
| B | THR374 |
| B | TRP375 |
| B | PRO376 |
| B | VAL377 |
| site_id | AE7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 407 |
| Chain | Residue |
| B | VAL158 |
| B | PRO298 |
| B | ASP299 |
| B | GLY347 |
| B | LYS349 |
| B | HOH690 |
| site_id | AE8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 408 |
| Chain | Residue |
| B | HOH508 |
| B | HOH616 |
| B | HOH735 |
| site_id | AE9 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 409 |
| Chain | Residue |
| A | PRO40 |
| B | ASN117 |
| B | GLN120 |
| B | THR121 |
| B | HOH539 |
| B | HOH545 |
| B | HOH568 |
| site_id | AF1 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 410 |
| site_id | AF2 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 411 |
| site_id | AF3 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 412 |
| site_id | AF4 |
| Number of Residues | 3 |
| Details | binding site for residue NA B 413 |
| Chain | Residue |
| B | SER77 |
| B | ALA78 |
| B | GLU79 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | Region: {"description":"Substrate binding","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 26 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"O04385","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01020","evidenceCode":"ECO:0000255"}]} |
6IX5
