6IWI
Crystal structure of PDE5A in complex with a novel inhibitor
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 900 |
| Chain | Residue |
| A | ASP654 |
| A | GLU682 |
| A | HOH1014 |
| A | HOH1019 |
| A | HOH1046 |
| A | HOH1065 |
| A | HOH1093 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue ZN A 901 |
| Chain | Residue |
| A | ASP654 |
| A | ASP764 |
| A | HOH1028 |
| A | HOH1065 |
| A | HIS617 |
| A | HIS653 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue B0C A 902 |
| Chain | Residue |
| A | TYR612 |
| A | ALA779 |
| A | PHE786 |
| A | GLN817 |
| A | GLY819 |
| A | PHE820 |
| A | HOH1015 |
| A | HOH1018 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGvnNsY |
| Chain | Residue | Details |
| A | HIS653-TYR664 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"O76083","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12955149","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12955149","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
