6IUN
Crystal structure of enoyl-CoA hydratase (ECH) from Ralstonia eutropha H16 in complex with NAD
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003857 | molecular_function | (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity |
| A | 0004300 | molecular_function | enoyl-CoA hydratase activity |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006635 | biological_process | fatty acid beta-oxidation |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0070403 | molecular_function | NAD+ binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0003857 | molecular_function | (3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity |
| B | 0004300 | molecular_function | enoyl-CoA hydratase activity |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006635 | biological_process | fatty acid beta-oxidation |
| B | 0016042 | biological_process | lipid catabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue GOL B 801 |
| Chain | Residue |
| B | LYS127 |
| B | PHE227 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 802 |
| Chain | Residue |
| B | HIS78 |
| B | ILE81 |
| B | GLU85 |
| B | ALA134 |
| B | GLY135 |
| B | ARG139 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 803 |
| Chain | Residue |
| B | LYS279 |
| B | ILE280 |
| B | VAL283 |
| B | GLU285 |
| B | SER278 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | binding site for residue NAD B 804 |
| Chain | Residue |
| B | GLY299 |
| B | GLY301 |
| B | THR302 |
| B | MET303 |
| B | GLU322 |
| B | THR323 |
| B | TYR366 |
| B | ALA378 |
| B | VAL379 |
| B | PHE380 |
| B | GLU381 |
| B | VAL385 |
| B | VAL389 |
| B | ASN406 |
| B | SER408 |
| B | THR409 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 801 |
| Chain | Residue |
| A | VAL126 |
| A | LYS127 |
| A | PHE227 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 802 |
| Chain | Residue |
| A | ASP411 |
| A | ASN413 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 803 |
| Chain | Residue |
| A | SER486 |
| A | PRO515 |
| A | ASN524 |
| A | TRP564 |
| site_id | AC8 |
| Number of Residues | 15 |
| Details | binding site for residue NAD A 804 |
| Chain | Residue |
| A | GLY301 |
| A | THR302 |
| A | MET303 |
| A | GLU322 |
| A | ALA378 |
| A | VAL379 |
| A | PHE380 |
| A | GLU381 |
| A | VAL385 |
| A | LYS386 |
| A | VAL389 |
| A | ASN406 |
| A | THR407 |
| A | SER408 |
| A | HOH917 |
