6IU3
Crystal structure of iron transporter VIT1 with zinc ions
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005384 | molecular_function | manganese ion transmembrane transporter activity |
| A | 0005774 | cellular_component | vacuolar membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006826 | biological_process | iron ion transport |
| A | 0006879 | biological_process | intracellular iron ion homeostasis |
| A | 0030026 | biological_process | intracellular manganese ion homeostasis |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0071421 | biological_process | manganese ion transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue OLC A 301 |
| Chain | Residue |
| A | LEU208 |
| A | TYR212 |
| A | ALA226 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue ZN A 302 |
| Chain | Residue |
| A | ZN304 |
| A | GLU102 |
| A | GLU105 |
| A | GLU113 |
| A | GLU116 |
| A | GLU153 |
| A | ZN303 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue ZN A 303 |
| Chain | Residue |
| A | GLU102 |
| A | GLU113 |
| A | GLU116 |
| A | MET149 |
| A | ZN302 |
| A | ZN304 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue ZN A 304 |
| Chain | Residue |
| A | GLU102 |
| A | GLU105 |
| A | GLU113 |
| A | GLU116 |
| A | ZN302 |
| A | ZN303 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 100 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Topological domain: {"description":"Vacuolar","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 95 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 75 |
| Details | Region: {"description":"Cytoplasmic metal binding domain (MBD)","evidences":[{"source":"PubMed","id":"30742036","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30742036","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6IU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6IU4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
