6ITL

Crystal structure of malate dehydrogenase from Mannheimia succiniciproducens in complex with NAD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006099	biological_process	tricarboxylic acid cycle
A	0006108	biological_process	malate metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016615	molecular_function	malate dehydrogenase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0019752	biological_process	carboxylic acid metabolic process
A	0030060	molecular_function	L-malate dehydrogenase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	31
Details	binding site for residue NAD A 401

Chain	Residue
A	GLY7
A	GLY78
A	VAL79
A	ALA80
A	ASN94
A	ILE117
A	THR118
A	ASN119
A	VAL121
A	ILE146
A	HIS177
A	ALA9
A	ALA224
A	THR225
A	MET228
A	HOH502
A	HOH514
A	HOH531
A	HOH536
A	HOH542
A	HOH543
A	HOH557
A	GLY10
A	HOH578
A	HOH602
A	GLY11
A	ILE12
A	TYR33
A	ASP34
A	SER76
A	ALA77

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site_id	AC2
Number of Residues	8
Details	binding site for residue GOL A 402

Chain	Residue
A	ASP71
A	LEU239
A	SER243
A	GLY271
A	THR272
A	GLU273
A	GLY274
A	HOH501

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Functional Information from PROSITE/UniProt

site_id	PS00068
Number of Residues	13
Details	MDH Malate dehydrogenase active site signature. ITTLDilRAetfI

Chain	Residue	Details
A	ILE146-ILE158

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_01516

Chain	Residue	Details
A	HIS177

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site_id	SWS_FT_FI2
Number of Residues	9
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01516

Chain	Residue	Details
A	GLY7
A	ASP34
A	ARG81
A	ARG87
A	ASN94
A	ILE117
A	ASN119
A	ARG153
A	MET228

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