6ISS

Lignin peroxidase H8 triple mutant S49C/A67C/H239

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000302	biological_process	response to reactive oxygen species
A	0004601	molecular_function	peroxidase activity
A	0006979	biological_process	response to oxidative stress
A	0016690	molecular_function	diarylpropane peroxidase activity
A	0020037	molecular_function	heme binding
A	0034599	biological_process	cellular response to oxidative stress
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0046274	biological_process	lignin catabolic process
A	0046872	molecular_function	metal ion binding
A	0098869	biological_process	cellular oxidant detoxification
G	0000302	biological_process	response to reactive oxygen species
G	0004601	molecular_function	peroxidase activity
G	0006979	biological_process	response to oxidative stress
G	0016690	molecular_function	diarylpropane peroxidase activity
G	0020037	molecular_function	heme binding
G	0034599	biological_process	cellular response to oxidative stress
G	0042744	biological_process	hydrogen peroxide catabolic process
G	0046274	biological_process	lignin catabolic process
G	0046872	molecular_function	metal ion binding
G	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	binding site for residue HEM A 401

Chain	Residue
A	HIS39
A	ALA175
A	HIS176
A	ALA179
A	ALA180
A	VAL181
A	ASN182
A	ASP183
A	PHE193
A	ILE235
A	SER237
A	GLU40
A	HOH512
A	HOH549
A	HOH612
A	HOH632
A	HOH670
A	ARG43
A	PHE46
A	ILE85
A	PRO145
A	GLU146
A	MET172
A	LEU173

---

site_id	AC2
Number of Residues	6
Details	binding site for residue CA A 402

Chain	Residue
A	ASP48
A	GLY66
A	ASP68
A	SER70
A	HOH567
A	HOH623

---

site_id	AC3
Number of Residues	5
Details	binding site for residue CA A 403

Chain	Residue
A	SER177
A	ASP194
A	THR196
A	ILE199
A	ASP201

---

site_id	AC4
Number of Residues	24
Details	binding site for residue HEM G 401

Chain	Residue
G	HIS39
G	GLU40
G	ARG43
G	PHE46
G	ILE85
G	PRO145
G	GLU146
G	MET172
G	LEU173
G	ALA175
G	HIS176
G	ALA179
G	ALA180
G	VAL181
G	ASN182
G	ASP183
G	PHE193
G	ILE235
G	SER237
G	HOH507
G	HOH511
G	HOH515
G	HOH668
G	HOH708

---

site_id	AC5
Number of Residues	6
Details	binding site for residue CA G 402

Chain	Residue
G	ASP48
G	GLY66
G	ASP68
G	SER70
G	HOH579
G	HOH625

---

site_id	AC6
Number of Residues	5
Details	binding site for residue CA G 403

Chain	Residue
G	SER177
G	ASP194
G	THR196
G	ILE199
G	ASP201

---

Functional Information from PROSITE/UniProt

site_id	PS00435
Number of Residues	11
Details	PEROXIDASE_1 Peroxidases proximal heme-ligand signature. ELVWMLSAHSV

Chain	Residue	Details
A	GLU168-VAL178

---

site_id	PS00436
Number of Residues	12
Details	PEROXIDASE_2 Peroxidases active site signature. AHesIRLvFHDC

Chain	Residue	Details
A	ALA38-CYS49

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor

Chain	Residue	Details
A	HIS47
G	HIS47

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	BINDING:

Chain	Residue	Details
A	THR196
A	ILE199
A	ASP201
G	ASP48
G	GLY66
G	ASP68
G	SER70
G	SER177
G	ASP194
G	THR196
G	ILE199
G	ASP201
A	ASP48
A	GLY66
A	ASP68
A	SER70
A	SER177
A	ASP194

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: axial binding residue

Chain	Residue	Details
A	HIS176
G	HIS176

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Transition state stabilizer

Chain	Residue	Details
A	ARG43
G	ARG43

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN257
G	ASN257

---