6ISO

Human SIRT3 Recognizing H3K4cr

Replaces:  4V1C

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0017136	molecular_function	histone deacetylase activity, NAD-dependent
A	0051287	molecular_function	NAD binding
A	0070403	molecular_function	NAD+ binding
B	0017136	molecular_function	histone deacetylase activity, NAD-dependent
B	0051287	molecular_function	NAD binding
B	0070403	molecular_function	NAD+ binding
E	0017136	molecular_function	histone deacetylase activity, NAD-dependent
E	0051287	molecular_function	NAD binding
E	0070403	molecular_function	NAD+ binding
G	0017136	molecular_function	histone deacetylase activity, NAD-dependent
G	0051287	molecular_function	NAD binding
G	0070403	molecular_function	NAD+ binding
I	0017136	molecular_function	histone deacetylase activity, NAD-dependent
I	0051287	molecular_function	NAD binding
I	0070403	molecular_function	NAD+ binding
K	0017136	molecular_function	histone deacetylase activity, NAD-dependent
K	0051287	molecular_function	NAD binding
K	0070403	molecular_function	NAD+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue ZN A 401

Chain	Residue
A	CYS256
A	CYS259
A	CYS280
A	CYS283
A	HOH531

---

site_id	AC2
Number of Residues	5
Details	binding site for residue CRD C 101

Chain	Residue
C	LYS2
A	PHE180
A	ILE230
A	HIS248
A	VAL292

---

site_id	AC3
Number of Residues	8
Details	binding site for residue GOL B 401

Chain	Residue
B	ALA146
B	PHE157
B	GLN228
B	HIS248
B	THR320
B	SER321
B	HOH503
D	CRD101

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN B 402

Chain	Residue
B	CYS256
B	CYS259
B	CYS280
B	CYS283

---

site_id	AC5
Number of Residues	3
Details	binding site for residue GOL E 401

Chain	Residue
E	GLU323
E	HOH503
F	CRD101

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN E 402

Chain	Residue
E	CYS256
E	CYS259
E	CYS280
E	CYS283

---

site_id	AC7
Number of Residues	6
Details	binding site for residue GOL G 401

Chain	Residue
G	GLY145
G	ALA146
G	GLN228
G	HIS248
G	THR320
G	SER321

---

site_id	AC8
Number of Residues	7
Details	binding site for residue ZN G 402

Chain	Residue
G	CYS256
G	VAL258
G	ARG261
G	HOH508
G	HOH530
G	HOH532
G	HOH533

---

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN I 401

Chain	Residue
I	CYS256
I	CYS259
I	CYS280
I	CYS283

---

site_id	AD1
Number of Residues	3
Details	binding site for residue GOL K 401

Chain	Residue
K	GLN228
K	THR320
L	CRD101

---

site_id	AD2
Number of Residues	13
Details	binding site for Di-peptide CRD D 101 and LYS D 2

Chain	Residue
B	PHE157
B	GLN228
B	ILE230
B	HIS248
B	VAL292
B	PHE293
B	PHE294
B	GLY295
B	GLU296
B	GLU325
B	GOL401
D	THR1
D	GLN3

---

site_id	AD3
Number of Residues	10
Details	binding site for Di-peptide CRD F 101 and LYS F 2

Chain	Residue
E	PHE180
E	HIS248
E	VAL292
E	PHE293
E	PHE294
E	GLY295
E	GLU325
E	GOL401
F	THR1
F	GLN3

---

site_id	AD4
Number of Residues	11
Details	binding site for Di-peptide CRD H 101 and LYS H 2

Chain	Residue
G	PHE180
G	ILE230
G	HIS248
G	VAL292
G	PHE293
G	PHE294
G	GLY295
G	GLU296
G	GLU325
H	THR1
H	GLN3

---

site_id	AD5
Number of Residues	10
Details	binding site for Di-peptide CRD J 101 and LYS J 2

Chain	Residue
I	PHE180
I	ILE230
I	HIS248
I	VAL292
I	PHE294
I	GLY295
I	GLU296
I	GLU325
J	THR1
J	GLN3

---

site_id	AD6
Number of Residues	10
Details	binding site for Di-peptide CRD L 101 and LYS L 2

Chain	Residue
K	GLU325
K	GOL401
L	THR1
L	GLN3
K	HIS248
K	VAL292
K	PHE294
K	GLY295
K	GLU296
K	VAL324

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12186850","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16788062","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18794531","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36896611","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	42
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23897466","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19535340","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23897466","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36896611","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37720100","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19535340","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23897466","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36896611","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	5
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q8R104","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---