6ISE
Crystal structure of AMPPNP bound CK2 alpha from C. neoformans
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005829 | cellular_component | cytosol |
| A | 0005956 | cellular_component | protein kinase CK2 complex |
| A | 0006356 | biological_process | regulation of transcription by RNA polymerase I |
| A | 0006359 | biological_process | regulation of transcription by RNA polymerase III |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0006974 | biological_process | DNA damage response |
| A | 0016310 | biological_process | phosphorylation |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0051726 | biological_process | regulation of cell cycle |
| A | 0106310 | molecular_function | protein serine kinase activity |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005829 | cellular_component | cytosol |
| B | 0005956 | cellular_component | protein kinase CK2 complex |
| B | 0006356 | biological_process | regulation of transcription by RNA polymerase I |
| B | 0006359 | biological_process | regulation of transcription by RNA polymerase III |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0006974 | biological_process | DNA damage response |
| B | 0016310 | biological_process | phosphorylation |
| B | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| B | 0051726 | biological_process | regulation of cell cycle |
| B | 0106310 | molecular_function | protein serine kinase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 401 |
| Chain | Residue |
| B | LYS76 |
| B | ARG79 |
| B | ARG154 |
| B | ASN188 |
| B | HOH501 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 402 |
| Chain | Residue |
| B | ARG277 |
| B | PRO279 |
| B | TRP280 |
| B | SER281 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for residue ANP B 403 |
| Chain | Residue |
| B | GLY47 |
| B | SER50 |
| B | VAL52 |
| B | LYS67 |
| B | GLU113 |
| B | VAL115 |
| B | ASP155 |
| B | LYS157 |
| B | HIS159 |
| B | ASN160 |
| B | ILE173 |
| B | ASP174 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 401 |
| Chain | Residue |
| A | ARG277 |
| A | PRO279 |
| A | TRP280 |
| A | SER281 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 402 |
| Chain | Residue |
| A | LYS76 |
| A | ARG79 |
| A | ARG154 |
| A | ASN188 |
| A | HOH502 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | binding site for residue ANP A 403 |
| Chain | Residue |
| A | ARG46 |
| A | GLY47 |
| A | SER50 |
| A | VAL52 |
| A | LYS67 |
| A | GLU113 |
| A | VAL115 |
| A | ASP155 |
| A | LYS157 |
| A | HIS159 |
| A | ASN160 |
| A | MET162 |
| A | ILE173 |
| A | ASP174 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 404 |
| Chain | Residue |
| A | VAL10 |
| A | HIS147 |
| A | TYR210 |
| A | SER211 |
| A | THR313 |
| A | ALA314 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGRGKYSEVFeSihlptdsk..........CIVK |
| Chain | Residue | Details |
| B | VAL44-LYS67 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI |
| Chain | Residue | Details |
| B | ILE151-ILE163 |
