Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6IRH

Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 6.3, Class III

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
A	0038023	molecular_function	signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
B	0038023	molecular_function	signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
C	0038023	molecular_function	signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane
D	0038023	molecular_function	signaling receptor activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	244
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"34186027","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EOQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	20
Details	Intramembrane: {"description":"Discontinuously helical","evidences":[{"source":"PubMed","id":"34186027","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EOQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26875626","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26919761","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28105280","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5H8F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I2K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I2N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KCJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TP9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TPA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26875626","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26919761","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28105280","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36959261","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5H8F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I2K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I2N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KCJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TP9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TPA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YFF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26875626","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26919761","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28105280","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36309015","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36959261","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E96","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"5H8F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I2K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I2N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KCJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TP9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TPA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YFR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26875626","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26919761","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28105280","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36309015","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36959261","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E96","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"5H8F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I2K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I2N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KCJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TP9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TPA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YFF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36309015","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E92","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E93","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E94","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E97","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E98","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E99","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36309015","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36959261","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E92","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E93","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E94","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E97","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7YFR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36309015","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E93","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E97","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"34186027","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36309015","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E92","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E93","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E94","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E96","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E97","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7EOQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	16
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36309015","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E93","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E94","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E96","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E97","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"36309015","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E92","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E94","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E97","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"34186027","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36309015","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36959261","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E93","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E94","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E97","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E98","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7EOQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7YFR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"34186027","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36309015","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E92","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E93","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E94","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E96","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E97","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E98","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"8E99","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7EOQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q00959","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26875626","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26919761","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28105280","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5H8F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5H8Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I2K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5I2N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KCJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KDT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5TP9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"34186027","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EOS","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"34186027","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7EOQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EOR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EOT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7EOU","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)