6IOI
Crystal structure of Homoserine O-acetyltransferase in complex with CoA from Mycobacterium smegmatis ATCC 19420
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004414 | molecular_function | homoserine O-acetyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009086 | biological_process | methionine biosynthetic process |
| A | 0009092 | biological_process | homoserine metabolic process |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0004414 | molecular_function | homoserine O-acetyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0009086 | biological_process | methionine biosynthetic process |
| B | 0009092 | biological_process | homoserine metabolic process |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue COA A 401 |
| Chain | Residue |
| A | LEU55 |
| A | GLN264 |
| A | LYS267 |
| A | ASP346 |
| A | LEU349 |
| A | VAL350 |
| A | HOH600 |
| A | HOH663 |
| A | HOH748 |
| A | THR56 |
| A | ARG222 |
| A | ARG230 |
| A | GLN244 |
| A | ALA256 |
| A | SER259 |
| A | TYR260 |
| A | TYR263 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | binding site for residue COA B 401 |
| Chain | Residue |
| B | LEU55 |
| B | THR56 |
| B | ARG222 |
| B | TYR229 |
| B | ARG230 |
| B | GLN244 |
| B | ALA256 |
| B | SER259 |
| B | TYR260 |
| B | TYR263 |
| B | GLN264 |
| B | LYS267 |
| B | ASP346 |
| B | LEU349 |
| B | VAL350 |
| B | HOH524 |
| B | HOH525 |
| B | HOH573 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_00296 |
| Chain | Residue | Details |
| A | SER152 | |
| B | SER152 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00296 |
| Chain | Residue | Details |
| A | ASP315 | |
| A | HIS345 | |
| B | ASP315 | |
| B | HIS345 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00296 |
| Chain | Residue | Details |
| A | ARG222 | |
| A | ASP346 | |
| B | ARG222 | |
| B | ASP346 |
