6IN0

Crystal structure of EphA3 in complex with 18-Crown-6

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue CL A 1001

Chain	Residue
A	ILE788
A	ARG789

---

site_id	AC2
Number of Residues	4
Details	binding site for residue CL A 1002

Chain	Residue
A	LEU616
A	ASP617
A	ASN620
A	HOH1227

---

site_id	AC3
Number of Residues	7
Details	binding site for residue O4B A 1003

Chain	Residue
A	MET674
A	ILE697
A	SER763
A	HOH1219
A	PHE632
A	LYS653
A	GLU670

---

site_id	AC4
Number of Residues	1
Details	binding site for residue O4B A 1004

Chain	Residue
A	LYS646

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	27
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGAGEFGEVCsGrlklpskkeis.......VAIK

Chain	Residue	Details
A	VAL627-LYS653

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YVHrDLAARNILI

Chain	Residue	Details
A	TYR742-ILE754

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	13
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"18547520","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---