6IME
Rv2361c complex with substrate analogues
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0004659 | molecular_function | prenyltransferase activity |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0008834 | molecular_function | di-trans,poly-cis-undecaprenyl-diphosphate synthase activity |
A | 0016094 | biological_process | polyprenol biosynthetic process |
A | 0016740 | molecular_function | transferase activity |
A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
A | 0030145 | molecular_function | manganese ion binding |
A | 0033850 | molecular_function | Z-farnesyl diphosphate synthase activity |
A | 0045547 | molecular_function | dehydrodolichyl diphosphate synthase activity |
A | 0046872 | molecular_function | metal ion binding |
A | 0052923 | molecular_function | all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0004659 | molecular_function | prenyltransferase activity |
B | 0005829 | cellular_component | cytosol |
B | 0005886 | cellular_component | plasma membrane |
B | 0008834 | molecular_function | di-trans,poly-cis-undecaprenyl-diphosphate synthase activity |
B | 0016094 | biological_process | polyprenol biosynthetic process |
B | 0016740 | molecular_function | transferase activity |
B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
B | 0030145 | molecular_function | manganese ion binding |
B | 0033850 | molecular_function | Z-farnesyl diphosphate synthase activity |
B | 0045547 | molecular_function | dehydrodolichyl diphosphate synthase activity |
B | 0046872 | molecular_function | metal ion binding |
B | 0052923 | molecular_function | all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 18 |
Details | binding site for residue GST A 301 |
Chain | Residue |
A | MET75 |
A | ALA119 |
A | ARG127 |
A | PHE138 |
A | HOH406 |
A | HOH418 |
A | HOH419 |
A | HOH434 |
B | ARG144 |
B | ARG292 |
A | ASP76 |
A | GLY77 |
A | ASN78 |
A | GLY79 |
A | ARG80 |
A | ARG89 |
A | HIS93 |
A | TYR118 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue MG A 302 |
Chain | Residue |
A | TYR261 |
A | PHE293 |
A | GLY294 |
A | HOH401 |
B | ISY307 |
B | HOH422 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue CL B 301 |
Chain | Residue |
B | ARG66 |
B | SER169 |
B | ARG291 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue CO3 B 302 |
Chain | Residue |
B | ASN12 |
B | TRP125 |
B | ARG165 |
B | DTT303 |
B | HOH454 |
site_id | AC5 |
Number of Residues | 10 |
Details | binding site for residue DTT B 303 |
Chain | Residue |
B | ASN12 |
B | ALA64 |
B | TRP125 |
B | LYS126 |
B | ARG127 |
B | SER128 |
B | PRO129 |
B | CO3302 |
B | HOH446 |
B | HOH454 |
site_id | AC6 |
Number of Residues | 9 |
Details | binding site for residue GOL B 304 |
Chain | Residue |
B | ALA64 |
B | PRO68 |
B | ASN69 |
B | GLY111 |
B | ILE112 |
B | LYS113 |
B | PRO129 |
B | ARG133 |
B | HOH401 |
site_id | AC7 |
Number of Residues | 5 |
Details | binding site for residue MG B 305 |
Chain | Residue |
B | ASP76 |
B | GST306 |
B | ISY307 |
B | HOH458 |
B | HOH497 |
site_id | AC8 |
Number of Residues | 18 |
Details | binding site for residue GST B 306 |
Chain | Residue |
B | MET75 |
B | ASP76 |
B | GLY77 |
B | ASN78 |
B | GLY79 |
B | ARG80 |
B | ARG89 |
B | HIS93 |
B | ALA119 |
B | ARG127 |
B | TYR191 |
B | TRP271 |
B | MG305 |
B | ISY307 |
B | HOH404 |
B | HOH414 |
B | HOH497 |
B | HOH570 |
site_id | AC9 |
Number of Residues | 23 |
Details | binding site for residue ISY B 307 |
Chain | Residue |
A | TYR261 |
A | ARG292 |
A | PHE293 |
A | GLY294 |
A | MG302 |
A | HOH401 |
B | VAL74 |
B | ASP76 |
B | TYR118 |
B | ALA119 |
B | PHE120 |
B | ASN124 |
B | ARG127 |
B | ARG244 |
B | ARG250 |
B | SER252 |
B | MG305 |
B | GST306 |
B | HOH417 |
B | HOH422 |
B | HOH442 |
B | HOH458 |
B | HOH497 |
Functional Information from PROSITE/UniProt
site_id | PS01066 |
Number of Residues | 18 |
Details | UPP_SYNTHASE Undecaprenyl pyrophosphate synthase family signature. DLFLRTSGeqRsSnFMLW |
Chain | Residue | Details |
A | ASP240-TRP257 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: ACT_SITE => ECO:0000250 |
Chain | Residue | Details |
A | ASP76 | |
B | ASP76 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor |
Chain | Residue | Details |
A | ASN124 | |
B | ASN124 |
site_id | SWS_FT_FI3 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | ASP76 | |
B | GLU263 | |
A | TRP81 | |
A | HIS93 | |
A | TRP125 | |
A | GLU263 | |
B | ASP76 | |
B | TRP81 | |
B | HIS93 | |
B | TRP125 |
site_id | SWS_FT_FI4 |
Number of Residues | 14 |
Details | BINDING: |
Chain | Residue | Details |
A | ARG89 | |
B | ARG127 | |
B | ARG168 | |
B | ARG244 | |
B | ARG250 | |
B | ARG292 | |
A | SER121 | |
A | ARG127 | |
A | ARG168 | |
A | ARG244 | |
A | ARG250 | |
A | ARG292 | |
B | ARG89 | |
B | SER121 |