6IME
Rv2361c complex with substrate analogues
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004659 | molecular_function | prenyltransferase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008834 | molecular_function | ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] activity |
| A | 0016094 | biological_process | polyprenol biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0033850 | molecular_function | Z-farnesyl diphosphate synthase activity |
| A | 0045547 | molecular_function | ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052923 | molecular_function | all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004659 | molecular_function | prenyltransferase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008834 | molecular_function | ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific] activity |
| B | 0016094 | biological_process | polyprenol biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0033850 | molecular_function | Z-farnesyl diphosphate synthase activity |
| B | 0045547 | molecular_function | ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0052923 | molecular_function | all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue GST A 301 |
| Chain | Residue |
| A | MET75 |
| A | ALA119 |
| A | ARG127 |
| A | PHE138 |
| A | HOH406 |
| A | HOH418 |
| A | HOH419 |
| A | HOH434 |
| B | ARG144 |
| B | ARG292 |
| A | ASP76 |
| A | GLY77 |
| A | ASN78 |
| A | GLY79 |
| A | ARG80 |
| A | ARG89 |
| A | HIS93 |
| A | TYR118 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 302 |
| Chain | Residue |
| A | TYR261 |
| A | PHE293 |
| A | GLY294 |
| A | HOH401 |
| B | ISY307 |
| B | HOH422 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 301 |
| Chain | Residue |
| B | ARG66 |
| B | SER169 |
| B | ARG291 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue CO3 B 302 |
| Chain | Residue |
| B | ASN12 |
| B | TRP125 |
| B | ARG165 |
| B | DTT303 |
| B | HOH454 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | binding site for residue DTT B 303 |
| Chain | Residue |
| B | ASN12 |
| B | ALA64 |
| B | TRP125 |
| B | LYS126 |
| B | ARG127 |
| B | SER128 |
| B | PRO129 |
| B | CO3302 |
| B | HOH446 |
| B | HOH454 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 304 |
| Chain | Residue |
| B | ALA64 |
| B | PRO68 |
| B | ASN69 |
| B | GLY111 |
| B | ILE112 |
| B | LYS113 |
| B | PRO129 |
| B | ARG133 |
| B | HOH401 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 305 |
| Chain | Residue |
| B | ASP76 |
| B | GST306 |
| B | ISY307 |
| B | HOH458 |
| B | HOH497 |
| site_id | AC8 |
| Number of Residues | 18 |
| Details | binding site for residue GST B 306 |
| Chain | Residue |
| B | MET75 |
| B | ASP76 |
| B | GLY77 |
| B | ASN78 |
| B | GLY79 |
| B | ARG80 |
| B | ARG89 |
| B | HIS93 |
| B | ALA119 |
| B | ARG127 |
| B | TYR191 |
| B | TRP271 |
| B | MG305 |
| B | ISY307 |
| B | HOH404 |
| B | HOH414 |
| B | HOH497 |
| B | HOH570 |
| site_id | AC9 |
| Number of Residues | 23 |
| Details | binding site for residue ISY B 307 |
| Chain | Residue |
| A | TYR261 |
| A | ARG292 |
| A | PHE293 |
| A | GLY294 |
| A | MG302 |
| A | HOH401 |
| B | VAL74 |
| B | ASP76 |
| B | TYR118 |
| B | ALA119 |
| B | PHE120 |
| B | ASN124 |
| B | ARG127 |
| B | ARG244 |
| B | ARG250 |
| B | SER252 |
| B | MG305 |
| B | GST306 |
| B | HOH417 |
| B | HOH422 |
| B | HOH442 |
| B | HOH458 |
| B | HOH497 |
Functional Information from PROSITE/UniProt
| site_id | PS01066 |
| Number of Residues | 18 |
| Details | UPP_SYNTHASE Undecaprenyl pyrophosphate synthase family signature. DLFLRTSGeqRsSnFMLW |
| Chain | Residue | Details |
| A | ASP240-TRP257 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 30 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
