6IKA
HIV-1 reverse transcriptase with Q151M/G112S/D113A/Y115F/F116Y/F160L/I159L:DNA:entecavir-triphosphate ternary complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| A | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| A | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
| B | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| B | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| C | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| C | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
| D | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| D | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue ET9 A 601 |
| Chain | Residue |
| A | LYS65 |
| A | GLY152 |
| A | MET184 |
| A | ASP185 |
| A | LYS220 |
| A | MG603 |
| E | DC0 |
| E | DG1 |
| E | DC33 |
| A | ARG72 |
| A | ASP110 |
| A | VAL111 |
| A | SER112 |
| A | ALA113 |
| A | ALA114 |
| A | PHE115 |
| A | MET151 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 602 |
| Chain | Residue |
| A | GLN407 |
| A | ALA408 |
| A | THR409 |
| B | GLN394 |
| B | THR397 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 603 |
| Chain | Residue |
| A | ASP110 |
| A | VAL111 |
| A | SER112 |
| A | ASP185 |
| A | ET9601 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 501 |
| Chain | Residue |
| A | LEU92 |
| A | VAL381 |
| B | GLN23 |
| B | TRP24 |
| B | PRO25 |
| B | ASN137 |
| B | HOH602 |
| B | HOH620 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | binding site for residue ET9 C 601 |
| Chain | Residue |
| C | LYS65 |
| C | ARG72 |
| C | LEU74 |
| C | ASP110 |
| C | VAL111 |
| C | SER112 |
| C | ALA113 |
| C | PHE115 |
| C | GLY152 |
| C | MET184 |
| C | ASP185 |
| C | MG603 |
| F | DC0 |
| F | DG1 |
| F | DC33 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue GOL C 602 |
| Chain | Residue |
| C | LYS366 |
| C | THR369 |
| C | GLN407 |
| C | ALA408 |
| C | THR409 |
| C | HOH710 |
| D | ILE393 |
| D | GLN394 |
| D | THR397 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue MG C 603 |
| Chain | Residue |
| C | ASP110 |
| C | VAL111 |
| C | ASP185 |
| C | ET9601 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue GOL D 501 |
| Chain | Residue |
| C | LEU92 |
| C | VAL381 |
| D | GLN23 |
| D | PRO25 |
| D | ASN137 |
| D | HOH603 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | binding site for Di-nucleotide DG F 1 and OMC F 2 |
| Chain | Residue |
| C | ASN81 |
| C | GLU89 |
| C | GLY152 |
| C | PRO157 |
| C | ET9601 |
| F | DC0 |
| F | DC3 |
| F | DG32 |
| F | DC33 |
| site_id | AD1 |
| Number of Residues | 9 |
| Details | binding site for Di-nucleotide OMC F 2 and DC F 3 |
| Chain | Residue |
| C | GLU89 |
| C | GLN91 |
| C | ILE94 |
| C | PRO157 |
| C | TYR183 |
| F | DG1 |
| F | OMC4 |
| F | DG31 |
| F | DG32 |
| site_id | AD2 |
| Number of Residues | 12 |
| Details | binding site for Di-nucleotide DC F 3 and OMC F 4 |
| Chain | Residue |
| C | GLU89 |
| C | GLN91 |
| C | LEU92 |
| C | ILE94 |
| C | TYR183 |
| D | LYS22 |
| F | OMC2 |
| F | DC5 |
| F | DG30 |
| F | DG31 |
| F | DG32 |
| F | HOH106 |
| site_id | AD3 |
| Number of Residues | 9 |
| Details | binding site for Di-nucleotide OMC F 4 and DC F 5 |
| Chain | Residue |
| C | LEU92 |
| C | ILE94 |
| D | LYS22 |
| F | DC3 |
| F | DC6 |
| F | DG29 |
| F | DG30 |
| F | DG31 |
| F | HOH106 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| B | ASP110 | |
| B | ASP185 | |
| B | ASP186 | |
| D | ASP110 | |
| D | ASP185 | |
| D | ASP186 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | SITE: Essential for RT p66/p51 heterodimerization => ECO:0000250 |
| Chain | Residue | Details |
| B | TRP401 | |
| B | TRP414 | |
| D | TRP401 | |
| D | TRP414 |
