6IHE
Crystal structure of Malate dehydrogenase from Metallosphaera sedula
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| A | 0006089 | biological_process | lactate metabolic process |
| A | 0006090 | biological_process | pyruvate metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| B | 0006089 | biological_process | lactate metabolic process |
| B | 0006090 | biological_process | pyruvate metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue NAD A 401 |
| Chain | Residue |
| A | GLY10 |
| A | GLY79 |
| A | LYS80 |
| A | PRO81 |
| A | VAL118 |
| A | ASN120 |
| A | VAL144 |
| A | THR218 |
| A | MLT402 |
| A | HOH509 |
| A | HOH515 |
| A | LYS11 |
| A | HOH532 |
| A | HOH553 |
| A | HOH560 |
| A | HOH563 |
| A | ILE12 |
| A | TYR32 |
| A | ASP33 |
| A | ILE34 |
| A | ILE35 |
| A | SER77 |
| A | ALA78 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue MLT A 402 |
| Chain | Residue |
| A | ARG82 |
| A | ARG88 |
| A | ASN120 |
| A | ARG148 |
| A | HIS172 |
| A | PRO208 |
| A | ILE212 |
| A | THR218 |
| A | NAD401 |
| A | HOH509 |
| A | HOH560 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | LYS131 |
| A | TYR132 |
| A | LYS134 |
| A | GLU250 |
| A | HOH507 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue PGE A 404 |
| Chain | Residue |
| A | ASP27 |
| A | ASN58 |
| A | HOH526 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue PGE A 405 |
| Chain | Residue |
| A | PHE167 |
| A | THR182 |
| A | LEU273 |
| A | HOH580 |
| B | GLY267 |
| B | PRO268 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 406 |
| Chain | Residue |
| A | SER19 |
| A | VAL22 |
| A | SER23 |
| A | LYS53 |
| A | HOH504 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue PG4 A 407 |
| Chain | Residue |
| A | ASP72 |
| A | GLY112 |
| A | HOH568 |
| B | LYS186 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue PG4 A 408 |
| Chain | Residue |
| A | THR162 |
| A | SER163 |
| A | LYS186 |
| B | ASP72 |
| B | GLY112 |
| B | PGE405 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue PEG A 409 |
| Chain | Residue |
| A | GLU276 |
| site_id | AD1 |
| Number of Residues | 30 |
| Details | binding site for residue NAD B 401 |
| Chain | Residue |
| B | GLY10 |
| B | LYS11 |
| B | ILE12 |
| B | TYR32 |
| B | ASP33 |
| B | ILE34 |
| B | ILE35 |
| B | LEU38 |
| B | SER77 |
| B | ALA78 |
| B | GLY79 |
| B | LYS80 |
| B | PRO81 |
| B | ASN95 |
| B | ILE98 |
| B | VAL118 |
| B | ALA119 |
| B | ASN120 |
| B | VAL144 |
| B | THR218 |
| B | PRO222 |
| B | MLT402 |
| B | HOH502 |
| B | HOH503 |
| B | HOH515 |
| B | HOH530 |
| B | HOH534 |
| B | HOH538 |
| B | HOH571 |
| B | HOH578 |
| site_id | AD2 |
| Number of Residues | 8 |
| Details | binding site for residue MLT B 402 |
| Chain | Residue |
| B | THR218 |
| B | NAD401 |
| B | HOH502 |
| B | ARG82 |
| B | ARG88 |
| B | ASN120 |
| B | ARG148 |
| B | ILE212 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 403 |
| Chain | Residue |
| A | LYS231 |
| A | GLU237 |
| B | LYS231 |
| B | GLU237 |
| B | HOH565 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue PGE B 404 |
| Chain | Residue |
| A | ASP40 |
| A | LYS41 |
| A | ILE207 |
| B | LYS251 |
| site_id | AD5 |
| Number of Residues | 8 |
| Details | binding site for residue PGE B 405 |
| Chain | Residue |
| A | LYS186 |
| A | GLY187 |
| A | PG4408 |
| B | GLY112 |
| B | PHE136 |
| B | SER264 |
| B | SER265 |
| B | ILE266 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue PGE B 406 |
| Chain | Residue |
| B | SER108 |
| B | LYS109 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 407 |
| Chain | Residue |
| B | TRP280 |
| B | ASN283 |
| B | SER284 |
| B | LYS287 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 408 |
| Chain | Residue |
| B | PHE167 |
| B | THR182 |
| B | HOH501 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 409 |
| Chain | Residue |
| B | SER19 |
| B | VAL22 |
| B | SER23 |
| B | LYS53 |
| site_id | AE1 |
| Number of Residues | 3 |
| Details | binding site for residue PEG B 410 |
| Chain | Residue |
| B | GLU199 |
| B | ASP202 |
| B | HOH582 |
