6IHD
Crystal structure of Malate dehydrogenase from Metallosphaera sedula
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| A | 0006089 | biological_process | lactate metabolic process |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004459 | molecular_function | L-lactate dehydrogenase (NAD+) activity |
| B | 0006089 | biological_process | lactate metabolic process |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue NAD A 401 |
| Chain | Residue |
| A | GLY10 |
| A | ILE98 |
| A | VAL118 |
| A | ALA119 |
| A | ASN120 |
| A | THR218 |
| A | HOH511 |
| A | LYS11 |
| A | ILE12 |
| A | TYR32 |
| A | ASP33 |
| A | ILE34 |
| A | ILE35 |
| A | SER77 |
| A | ALA78 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue ETX A 402 |
| Chain | Residue |
| A | ARG47 |
| A | PHE50 |
| A | ILE55 |
| A | LYS56 |
| A | HOH505 |
| B | ILE159 |
| B | PRO160 |
| B | VAL161 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | binding site for residue NAD B 401 |
| Chain | Residue |
| B | GLY10 |
| B | LYS11 |
| B | ILE12 |
| B | TYR32 |
| B | ASP33 |
| B | ILE34 |
| B | ILE35 |
| B | SER77 |
| B | ALA78 |
| B | LYS80 |
| B | ARG82 |
| B | ILE98 |
| B | VAL118 |
| B | ALA119 |
| B | ASN120 |
| B | THR218 |
| B | PRO222 |
| B | HOH518 |
| B | HOH520 |
| B | HOH522 |
| B | HOH529 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue ETX B 402 |
| Chain | Residue |
| B | ASP165 |
| B | PHE167 |
| B | THR182 |
| B | SER265 |
| B | GLY267 |
