6IH3
Crystal structure of Phosphite Dehydrogenase from Ralstonia sp. 4506 in complex with non-natural cofactor Nicotinamide Cytosine Dinucleotide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005829 | cellular_component | cytosol |
| A | 0008465 | molecular_function | hydroxypyruvate reductase (NADH) activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0016618 | molecular_function | hydroxypyruvate reductase [NAD(P)H] activity |
| A | 0030267 | molecular_function | glyoxylate reductase (NADPH) activity |
| A | 0051287 | molecular_function | NAD binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0008465 | molecular_function | hydroxypyruvate reductase (NADH) activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0016618 | molecular_function | hydroxypyruvate reductase [NAD(P)H] activity |
| B | 0030267 | molecular_function | glyoxylate reductase (NADPH) activity |
| B | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue A7R A 400 |
| Chain | Residue |
| A | THR104 |
| A | ALA235 |
| A | CYS236 |
| A | ASP261 |
| A | HIS293 |
| A | GLY295 |
| A | HOH544 |
| A | HOH548 |
| A | HOH574 |
| A | HOH615 |
| A | HOH647 |
| A | GLY152 |
| A | HOH665 |
| A | HOH677 |
| A | HOH714 |
| A | HOH730 |
| A | GLY154 |
| A | ALA155 |
| A | VAL156 |
| A | ASP175 |
| A | PRO176 |
| A | MET207 |
| A | VAL208 |
Functional Information from PROSITE/UniProt
| site_id | PS00065 |
| Number of Residues | 28 |
| Details | D_2_HYDROXYACID_DH_1 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. LGIIGmGAVGraiaqrlagfemn.LLyCD |
| Chain | Residue | Details |
| A | LEU148-ASP175 |
| site_id | PS00671 |
| Number of Residues | 17 |
| Details | D_2_HYDROXYACID_DH_3 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. MKtGsYLINaCRGsVVD |
| Chain | Residue | Details |
| A | MET226-ASP242 |
