6IH1

Crystal structure of a standalone versatile EAL protein from Vibrio cholerae O395 - c-di-GMP bound form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0046872	molecular_function	metal ion binding
A	0071111	molecular_function	cyclic-guanylate-specific phosphodiesterase activity
B	0000166	molecular_function	nucleotide binding
B	0046872	molecular_function	metal ion binding
B	0071111	molecular_function	cyclic-guanylate-specific phosphodiesterase activity
C	0000166	molecular_function	nucleotide binding
C	0046872	molecular_function	metal ion binding
C	0071111	molecular_function	cyclic-guanylate-specific phosphodiesterase activity
D	0000166	molecular_function	nucleotide binding
D	0046872	molecular_function	metal ion binding
D	0071111	molecular_function	cyclic-guanylate-specific phosphodiesterase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	29
Details	binding site for residue C2E A 501

Chain	Residue
A	MET28
A	ASN95
A	LEU97
A	ASP158
A	ASP159
A	MET182
A	GLY216
A	VAL217
A	GLU218
A	GLY236
A	TYR237
A	GLN31
A	PRO242
A	CA502
A	CA503
A	HOH603
A	HOH630
A	HOH633
A	HOH648
A	HOH658
A	HOH670
A	HOH674
A	GLU45
A	LEU47
A	VAL48
A	ARG49
A	ALA56
A	ILE60
A	CYS75

---

site_id	AC2
Number of Residues	6
Details	binding site for residue CA A 502

Chain	Residue
A	GLU45
A	ASN95
A	GLU128
A	ASP158
A	C2E501
A	HOH601

---

site_id	AC3
Number of Residues	5
Details	binding site for residue CA A 503

Chain	Residue
A	ASP158
A	ASP159
A	GLU215
A	C2E501
A	HOH601

---

site_id	AC4
Number of Residues	27
Details	binding site for residue C2E B 501

Chain	Residue
B	GLN31
B	GLU45
B	LEU47
B	VAL48
B	ARG49
B	ILE60
B	CYS75
B	ASN95
B	LEU97
B	ASP158
B	ASP159
B	MET182
B	GLY216
B	VAL217
B	GLU218
B	GLY236
B	TYR237
B	PRO242
B	CA502
B	CA503
B	HOH611
B	HOH629
B	HOH660
B	HOH662
B	HOH676
B	HOH689
B	HOH702

---

site_id	AC5
Number of Residues	7
Details	binding site for residue CA B 502

Chain	Residue
B	GLU45
B	ASN95
B	GLU128
B	ASP158
B	C2E501
B	CA503
B	HOH602

---

site_id	AC6
Number of Residues	6
Details	binding site for residue CA B 503

Chain	Residue
B	ASP158
B	ASP159
B	GLU215
B	C2E501
B	CA502
B	HOH602

---

site_id	AC7
Number of Residues	32
Details	binding site for residue C2E C 501

Chain	Residue
C	TYR237
C	PRO242
C	CA502
C	CA503
C	HOH609
C	HOH611
C	HOH615
C	HOH621
C	HOH624
C	HOH630
C	HOH641
C	HOH655
C	HOH672
C	MET28
C	GLN31
C	GLU45
C	LEU47
C	VAL48
C	ARG49
C	ALA56
C	ILE60
C	CYS75
C	ASN95
C	LEU97
C	ASP158
C	ASP159
C	MET182
C	GLU215
C	GLY216
C	VAL217
C	GLU218
C	GLY236

---

site_id	AC8
Number of Residues	7
Details	binding site for residue CA C 502

Chain	Residue
C	GLU45
C	ASN95
C	GLU128
C	ASP158
C	C2E501
C	CA503
C	HOH615

---

site_id	AC9
Number of Residues	6
Details	binding site for residue CA C 503

Chain	Residue
C	ASP158
C	ASP159
C	GLU215
C	C2E501
C	CA502
C	HOH615

---

site_id	AD1
Number of Residues	30
Details	binding site for residue C2E D 501

Chain	Residue
D	MET28
D	GLN31
D	GLU45
D	LEU47
D	VAL48
D	ARG49
D	ALA56
D	ILE60
D	CYS75
D	ASN95
D	LEU97
D	ASP158
D	ASP159
D	MET182
D	GLU215
D	GLY216
D	VAL217
D	GLU218
D	GLY236
D	TYR237
D	PRO242
D	CA502
D	CA503
D	HOH609
D	HOH610
D	HOH639
D	HOH650
D	HOH651
D	HOH652
D	HOH681

---

site_id	AD2
Number of Residues	7
Details	binding site for residue CA D 502

Chain	Residue
D	GLU45
D	ASN95
D	GLU128
D	ASP158
D	C2E501
D	CA503
D	HOH603

---

site_id	AD3
Number of Residues	6
Details	binding site for residue CA D 503

Chain	Residue
D	ASP158
D	ASP159
D	GLU215
D	C2E501
D	CA502
D	HOH603

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