6IGS
Crystal structure of HPRT from F. tularensis with Zinc
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0006177 | biological_process | GMP biosynthetic process |
| A | 0006178 | biological_process | guanine salvage |
| A | 0006188 | biological_process | IMP biosynthetic process |
| A | 0032263 | biological_process | GMP salvage |
| A | 0032264 | biological_process | IMP salvage |
| A | 0043101 | biological_process | purine-containing compound salvage |
| A | 0046100 | biological_process | hypoxanthine metabolic process |
| A | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006166 | biological_process | purine ribonucleoside salvage |
| B | 0006177 | biological_process | GMP biosynthetic process |
| B | 0006178 | biological_process | guanine salvage |
| B | 0006188 | biological_process | IMP biosynthetic process |
| B | 0032263 | biological_process | GMP salvage |
| B | 0032264 | biological_process | IMP salvage |
| B | 0043101 | biological_process | purine-containing compound salvage |
| B | 0046100 | biological_process | hypoxanthine metabolic process |
| B | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006166 | biological_process | purine ribonucleoside salvage |
| C | 0006177 | biological_process | GMP biosynthetic process |
| C | 0006178 | biological_process | guanine salvage |
| C | 0006188 | biological_process | IMP biosynthetic process |
| C | 0032263 | biological_process | GMP salvage |
| C | 0032264 | biological_process | IMP salvage |
| C | 0043101 | biological_process | purine-containing compound salvage |
| C | 0046100 | biological_process | hypoxanthine metabolic process |
| C | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006166 | biological_process | purine ribonucleoside salvage |
| D | 0006177 | biological_process | GMP biosynthetic process |
| D | 0006178 | biological_process | guanine salvage |
| D | 0006188 | biological_process | IMP biosynthetic process |
| D | 0032263 | biological_process | GMP salvage |
| D | 0032264 | biological_process | IMP salvage |
| D | 0043101 | biological_process | purine-containing compound salvage |
| D | 0046100 | biological_process | hypoxanthine metabolic process |
| D | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 201 |
| Chain | Residue |
| A | LEU43 |
| A | LYS44 |
| A | GLY45 |
| A | HOH312 |
| A | HOH334 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 202 |
| Chain | Residue |
| A | THR110 |
| A | HOH316 |
| A | ASP106 |
| A | THR107 |
| A | GLY108 |
| A | HIS109 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue ZN A 203 |
| Chain | Residue |
| A | GLU102 |
| A | ASP103 |
| A | HOH305 |
| A | HOH312 |
| A | HOH318 |
| A | HOH334 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue ZN A 204 |
| Chain | Residue |
| A | HIS109 |
| A | HIS112 |
| A | GLU139 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 201 |
| Chain | Residue |
| B | ASP106 |
| B | THR107 |
| B | GLY108 |
| B | HIS109 |
| B | THR110 |
| B | HOH303 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 202 |
| Chain | Residue |
| A | LYS177 |
| B | HIS109 |
| B | HIS112 |
| B | GLU139 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue ZN B 203 |
| Chain | Residue |
| B | GLU102 |
| B | ASP103 |
| B | HOH322 |
| B | HOH335 |
| B | HOH344 |
| B | HOH346 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 C 201 |
| Chain | Residue |
| C | ASP106 |
| C | THR107 |
| C | GLY108 |
| C | THR110 |
| C | HOH303 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 C 202 |
| Chain | Residue |
| C | LEU43 |
| C | LYS44 |
| C | GLY45 |
| C | ASP162 |
| C | ZN203 |
| C | HOH301 |
| C | HOH302 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue ZN C 203 |
| Chain | Residue |
| C | GLU102 |
| C | ASP103 |
| C | SO4202 |
| C | HOH301 |
| C | HOH302 |
| C | HOH322 |
| C | HOH328 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue ZN C 204 |
| Chain | Residue |
| B | LYS177 |
| C | HIS109 |
| C | HIS112 |
| C | GLU139 |
| C | ARG140 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 D 201 |
| Chain | Residue |
| D | VAL105 |
| D | ASP106 |
| D | THR107 |
| D | GLY108 |
| D | HIS109 |
| D | THR110 |
| D | HOH302 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 D 202 |
| Chain | Residue |
| D | LYS44 |
| D | GLY45 |
| D | HOH309 |
| D | HOH313 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue ZN D 203 |
| Chain | Residue |
| D | GLU102 |
| D | ASP103 |
| D | HOH309 |
| D | HOH313 |
| D | HOH330 |
| D | HOH334 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 204 |
| Chain | Residue |
| C | LYS177 |
| D | HIS109 |
| D | HIS112 |
| D | GLU139 |
Functional Information from PROSITE/UniProt
| site_id | PS00103 |
| Number of Residues | 13 |
| Details | PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. IIIIEDIVDTGhT |
| Chain | Residue | Details |
| A | ILE98-THR110 |
