6IEM
Argininosuccinate lyase from Mycobacterium tuberculosis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004056 | molecular_function | argininosuccinate lyase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006526 | biological_process | L-arginine biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004056 | molecular_function | argininosuccinate lyase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006526 | biological_process | L-arginine biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004056 | molecular_function | argininosuccinate lyase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006526 | biological_process | L-arginine biosynthetic process |
| C | 0016829 | molecular_function | lyase activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004056 | molecular_function | argininosuccinate lyase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006526 | biological_process | L-arginine biosynthetic process |
| D | 0016829 | molecular_function | lyase activity |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004056 | molecular_function | argininosuccinate lyase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0006526 | biological_process | L-arginine biosynthetic process |
| E | 0016829 | molecular_function | lyase activity |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004056 | molecular_function | argininosuccinate lyase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0006526 | biological_process | L-arginine biosynthetic process |
| F | 0016829 | molecular_function | lyase activity |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0004056 | molecular_function | argininosuccinate lyase activity |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005829 | cellular_component | cytosol |
| G | 0006526 | biological_process | L-arginine biosynthetic process |
| G | 0016829 | molecular_function | lyase activity |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0004056 | molecular_function | argininosuccinate lyase activity |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005829 | cellular_component | cytosol |
| H | 0006526 | biological_process | L-arginine biosynthetic process |
| H | 0016829 | molecular_function | lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 501 |
| Chain | Residue |
| A | SER113 |
| A | GLY203 |
| A | ALA204 |
| A | LEU205 |
| A | ALA206 |
| A | GLY207 |
| B | GLN166 |
| B | GLU377 |
| B | ARG439 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 502 |
| Chain | Residue |
| A | ALA148 |
| A | PRO152 |
| A | PRO447 |
| A | LEU454 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue PG4 B 501 |
| Chain | Residue |
| B | THR28 |
| B | PRO81 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 502 |
| Chain | Residue |
| B | SER78 |
| B | PHE79 |
| B | GLY80 |
| B | ARG94 |
| B | ASP98 |
| E | ASN455 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 503 |
| Chain | Residue |
| B | LEU24 |
| B | SER25 |
| B | GLN327 |
| B | GLU331 |
| B | HOH625 |
| D | LYS300 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue PG4 C 501 |
| Chain | Residue |
| C | LEU138 |
| C | GLY142 |
| C | LEU454 |
| C | GLY458 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue EDO C 502 |
| Chain | Residue |
| C | THR40 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 501 |
| Chain | Residue |
| D | TRP32 |
| D | GLY80 |
| D | PRO81 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue EDO D 502 |
| Chain | Residue |
| D | ARG131 |
| D | THR135 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue P3G D 503 |
| Chain | Residue |
| D | LEU138 |
| D | ALA145 |
| D | LEU454 |
| D | ASN455 |
| D | GLY458 |
| D | GLU459 |
| site_id | AD2 |
| Number of Residues | 11 |
| Details | binding site for residue 2PE E 501 |
| Chain | Residue |
| D | ASP76 |
| E | LEU138 |
| E | ASP139 |
| E | GLY142 |
| E | ALA145 |
| E | GLU146 |
| E | ALA348 |
| E | GLY349 |
| E | LEU454 |
| E | ASN455 |
| E | GLY458 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO E 502 |
| Chain | Residue |
| E | GLN408 |
| E | THR431 |
| E | ILE432 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue PGE F 501 |
| Chain | Residue |
| F | LEU138 |
| F | GLY142 |
| F | ALA145 |
| F | LEU454 |
| F | ASN455 |
| F | GLY458 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO F 502 |
| Chain | Residue |
| F | PRO366 |
| F | TYR369 |
| F | LEU407 |
Functional Information from PROSITE/UniProt
| site_id | PS00163 |
| Number of Residues | 10 |
| Details | FUMARATE_LYASES Fumarate lyases signature. GSsiMpQKkN |
| Chain | Residue | Details |
| A | GLY281-ASN290 |
