Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6IEM

Argininosuccinate lyase from Mycobacterium tuberculosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004056	molecular_function	argininosuccinate lyase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006526	biological_process	arginine biosynthetic process
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0016829	molecular_function	lyase activity
A	0042450	biological_process	arginine biosynthetic process via ornithine
B	0003824	molecular_function	catalytic activity
B	0004056	molecular_function	argininosuccinate lyase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006526	biological_process	arginine biosynthetic process
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0016829	molecular_function	lyase activity
B	0042450	biological_process	arginine biosynthetic process via ornithine
C	0003824	molecular_function	catalytic activity
C	0004056	molecular_function	argininosuccinate lyase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006526	biological_process	arginine biosynthetic process
C	0009274	cellular_component	peptidoglycan-based cell wall
C	0016829	molecular_function	lyase activity
C	0042450	biological_process	arginine biosynthetic process via ornithine
D	0003824	molecular_function	catalytic activity
D	0004056	molecular_function	argininosuccinate lyase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006526	biological_process	arginine biosynthetic process
D	0009274	cellular_component	peptidoglycan-based cell wall
D	0016829	molecular_function	lyase activity
D	0042450	biological_process	arginine biosynthetic process via ornithine
E	0003824	molecular_function	catalytic activity
E	0004056	molecular_function	argininosuccinate lyase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006526	biological_process	arginine biosynthetic process
E	0009274	cellular_component	peptidoglycan-based cell wall
E	0016829	molecular_function	lyase activity
E	0042450	biological_process	arginine biosynthetic process via ornithine
F	0003824	molecular_function	catalytic activity
F	0004056	molecular_function	argininosuccinate lyase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006526	biological_process	arginine biosynthetic process
F	0009274	cellular_component	peptidoglycan-based cell wall
F	0016829	molecular_function	lyase activity
F	0042450	biological_process	arginine biosynthetic process via ornithine
G	0003824	molecular_function	catalytic activity
G	0004056	molecular_function	argininosuccinate lyase activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006526	biological_process	arginine biosynthetic process
G	0009274	cellular_component	peptidoglycan-based cell wall
G	0016829	molecular_function	lyase activity
G	0042450	biological_process	arginine biosynthetic process via ornithine
H	0003824	molecular_function	catalytic activity
H	0004056	molecular_function	argininosuccinate lyase activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006526	biological_process	arginine biosynthetic process
H	0009274	cellular_component	peptidoglycan-based cell wall
H	0016829	molecular_function	lyase activity
H	0042450	biological_process	arginine biosynthetic process via ornithine

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue GOL A 501

Chain	Residue
A	SER113
A	GLY203
A	ALA204
A	LEU205
A	ALA206
A	GLY207
B	GLN166
B	GLU377
B	ARG439

site_id	AC2
Number of Residues	4
Details	binding site for residue EDO A 502

Chain	Residue
A	ALA148
A	PRO152
A	PRO447
A	LEU454

site_id	AC3
Number of Residues	2
Details	binding site for residue PG4 B 501

Chain	Residue
B	THR28
B	PRO81

site_id	AC4
Number of Residues	6
Details	binding site for residue GOL B 502

Chain	Residue
B	SER78
B	PHE79
B	GLY80
B	ARG94
B	ASP98
E	ASN455

site_id	AC5
Number of Residues	6
Details	binding site for residue EDO B 503

Chain	Residue
B	LEU24
B	SER25
B	GLN327
B	GLU331
B	HOH625
D	LYS300

site_id	AC6
Number of Residues	4
Details	binding site for residue PG4 C 501

Chain	Residue
C	LEU138
C	GLY142
C	LEU454
C	GLY458

site_id	AC7
Number of Residues	1
Details	binding site for residue EDO C 502

Chain	Residue
C	THR40

site_id	AC8
Number of Residues	3
Details	binding site for residue EDO D 501

Chain	Residue
D	TRP32
D	GLY80
D	PRO81

site_id	AC9
Number of Residues	2
Details	binding site for residue EDO D 502

Chain	Residue
D	ARG131
D	THR135

site_id	AD1
Number of Residues	6
Details	binding site for residue P3G D 503

Chain	Residue
D	LEU138
D	ALA145
D	LEU454
D	ASN455
D	GLY458
D	GLU459

site_id	AD2
Number of Residues	11
Details	binding site for residue 2PE E 501

Chain	Residue
D	ASP76
E	LEU138
E	ASP139
E	GLY142
E	ALA145
E	GLU146
E	ALA348
E	GLY349
E	LEU454
E	ASN455
E	GLY458

site_id	AD3
Number of Residues	3
Details	binding site for residue EDO E 502

Chain	Residue
E	GLN408
E	THR431
E	ILE432

site_id	AD4
Number of Residues	6
Details	binding site for residue PGE F 501

Chain	Residue
F	LEU138
F	GLY142
F	ALA145
F	LEU454
F	ASN455
F	GLY458

site_id	AD5
Number of Residues	3
Details	binding site for residue EDO F 502

Chain	Residue
F	PRO366
F	TYR369
F	LEU407

Functional Information from PROSITE/UniProt

site_id	PS00163
Number of Residues	10
Details	FUMARATE_LYASES Fumarate lyases signature. GSsiMpQKkN

Chain	Residue	Details
A	GLY281-ASN290

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)