6IE3

Crystal structure of methyladenine demethylase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0000791	cellular_component	euchromatin
A	0001701	biological_process	in utero embryonic development
A	0001764	biological_process	neuron migration
A	0001890	biological_process	placenta development
A	0002101	biological_process	tRNA wobble cytosine modification
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005783	cellular_component	endoplasmic reticulum
A	0006281	biological_process	DNA repair
A	0006307	biological_process	DNA alkylation repair
A	0006417	biological_process	regulation of translation
A	0006446	biological_process	regulation of translational initiation
A	0006448	biological_process	regulation of translational elongation
A	0008198	molecular_function	ferrous iron binding
A	0010468	biological_process	regulation of gene expression
A	0016706	molecular_function	2-oxoglutarate-dependent dioxygenase activity
A	0016829	molecular_function	lyase activity
A	0030154	biological_process	cell differentiation
A	0031175	biological_process	neuron projection development
A	0035513	biological_process	oxidative RNA demethylation
A	0035515	molecular_function	oxidative RNA demethylase activity
A	0035516	molecular_function	broad specificity oxidative DNA demethylase activity
A	0042056	molecular_function	chemoattractant activity
A	0042245	biological_process	RNA repair
A	0043524	biological_process	negative regulation of neuron apoptotic process
A	0046872	molecular_function	metal ion binding
A	0048589	biological_process	developmental growth
A	0050918	biological_process	positive chemotaxis
A	0051213	molecular_function	dioxygenase activity
A	0070129	biological_process	regulation of mitochondrial translation
A	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A	0141131	molecular_function	DNA N6-methyladenine demethylase activity
A	0141137	biological_process	positive regulation of gene expression, epigenetic
A	1990983	biological_process	regulation of translational initiation by tRNA modification
A	1990984	molecular_function	tRNA demethylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue MN A 401

Chain	Residue
A	HIS231
A	ASP233
A	HIS287
A	HOH619
A	HOH661

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site_id	AC2
Number of Residues	2
Details	binding site for residue EOH A 402

Chain	Residue
A	TRP179
A	HOH578

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q6NS38

Chain	Residue	Details
A	TRP144
A	TYR175
A	ASP233

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q96Q83

Chain	Residue	Details
A	ASN220
A	ARG338

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00805, ECO:0000305|PubMed:19959401, ECO:0000305|PubMed:27745969

Chain	Residue	Details
A	HIS231

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site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00805

Chain	Residue	Details
A	HIS287

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site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Secondary catalytic residue forming the imine linkage with DNA => ECO:0000269|PubMed:23577621

Chain	Residue	Details
A	LYS133

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