6ID1

Cryo-EM structure of a human intron lariat spliceosome after Prp43 loaded (ILS2 complex) at 2.9 angstrom resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000244	biological_process	spliceosomal tri-snRNP complex assembly
A	0000375	biological_process	RNA splicing, via transesterification reactions
A	0000398	biological_process	mRNA splicing, via spliceosome
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005681	cellular_component	spliceosomal complex
A	0005682	cellular_component	U5 snRNP
A	0006397	biological_process	mRNA processing
A	0008233	molecular_function	peptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008380	biological_process	RNA splicing
A	0016020	cellular_component	membrane
A	0016607	cellular_component	nuclear speck
A	0017070	molecular_function	U6 snRNA binding
A	0030532	cellular_component	small nuclear ribonucleoprotein complex
A	0030619	molecular_function	U1 snRNA binding
A	0030620	molecular_function	U2 snRNA binding
A	0030623	molecular_function	U5 snRNA binding
A	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
A	0070530	molecular_function	K63-linked polyubiquitin modification-dependent protein binding
A	0071005	cellular_component	U2-type precatalytic spliceosome
A	0071006	cellular_component	U2-type catalytic step 1 spliceosome
A	0071007	cellular_component	U2-type catalytic step 2 spliceosome
A	0071013	cellular_component	catalytic step 2 spliceosome
A	0071222	biological_process	cellular response to lipopolysaccharide
A	0071356	biological_process	cellular response to tumor necrosis factor
A	0097157	molecular_function	pre-mRNA intronic binding
A	0140492	molecular_function	metal-dependent deubiquitinase activity
A	1990904	cellular_component	ribonucleoprotein complex
C	0000166	molecular_function	nucleotide binding
C	0000398	biological_process	mRNA splicing, via spliceosome
C	0003723	molecular_function	RNA binding
C	0003924	molecular_function	GTPase activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005681	cellular_component	spliceosomal complex
C	0005829	cellular_component	cytosol
C	0006397	biological_process	mRNA processing
C	0008380	biological_process	RNA splicing
C	0015030	cellular_component	Cajal body
C	0016020	cellular_component	membrane
C	0016607	cellular_component	nuclear speck
C	0030623	molecular_function	U5 snRNA binding
C	0042220	biological_process	response to cocaine
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
C	0071005	cellular_component	U2-type precatalytic spliceosome
C	0071007	cellular_component	U2-type catalytic step 2 spliceosome
C	0071013	cellular_component	catalytic step 2 spliceosome
C	0071466	biological_process	cellular response to xenobiotic stimulus
E	0000375	biological_process	RNA splicing, via transesterification reactions
E	0000398	biological_process	mRNA splicing, via spliceosome
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005681	cellular_component	spliceosomal complex
E	0005682	cellular_component	U5 snRNP
E	0005732	cellular_component	sno(s)RNA-containing ribonucleoprotein complex
E	0005829	cellular_component	cytosol
E	0006396	biological_process	RNA processing
E	0006397	biological_process	mRNA processing
E	0008380	biological_process	RNA splicing
E	0016607	cellular_component	nuclear speck
E	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
E	0071007	cellular_component	U2-type catalytic step 2 spliceosome
E	0071013	cellular_component	catalytic step 2 spliceosome
I	0000349	biological_process	generation of catalytic spliceosome for first transesterification step
I	0000398	biological_process	mRNA splicing, via spliceosome
I	0000974	cellular_component	Prp19 complex
I	0001824	biological_process	blastocyst development
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005681	cellular_component	spliceosomal complex
I	0006281	biological_process	DNA repair
I	0006283	biological_process	transcription-coupled nucleotide-excision repair
I	0006351	biological_process	DNA-templated transcription
I	0006396	biological_process	RNA processing
I	0006397	biological_process	mRNA processing
I	0006974	biological_process	DNA damage response
I	0008380	biological_process	RNA splicing
I	0016020	cellular_component	membrane
I	0043231	cellular_component	intracellular membrane-bounded organelle
I	0071007	cellular_component	U2-type catalytic step 2 spliceosome
I	0071013	cellular_component	catalytic step 2 spliceosome
I	0071014	cellular_component	post-mRNA release spliceosomal complex
J	0000245	biological_process	spliceosomal complex assembly
J	0000398	biological_process	mRNA splicing, via spliceosome
J	0000974	cellular_component	Prp19 complex
J	0003723	molecular_function	RNA binding
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005681	cellular_component	spliceosomal complex
J	0006396	biological_process	RNA processing
J	0006397	biological_process	mRNA processing
J	0008380	biological_process	RNA splicing
J	0016607	cellular_component	nuclear speck
J	0071007	cellular_component	U2-type catalytic step 2 spliceosome
J	0071011	cellular_component	precatalytic spliceosome
J	0071013	cellular_component	catalytic step 2 spliceosome
J	0071014	cellular_component	post-mRNA release spliceosomal complex
K	0000375	biological_process	RNA splicing, via transesterification reactions
K	0000398	biological_process	mRNA splicing, via spliceosome
K	0000974	cellular_component	Prp19 complex
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005662	cellular_component	DNA replication factor A complex
K	0005681	cellular_component	spliceosomal complex
K	0005730	cellular_component	nucleolus
K	0005813	cellular_component	centrosome
K	0006397	biological_process	mRNA processing
K	0008380	biological_process	RNA splicing
K	0016607	cellular_component	nuclear speck
K	0071007	cellular_component	U2-type catalytic step 2 spliceosome
K	0071011	cellular_component	precatalytic spliceosome
K	0071013	cellular_component	catalytic step 2 spliceosome
L	0000077	biological_process	DNA damage checkpoint signaling
L	0000398	biological_process	mRNA splicing, via spliceosome
L	0000974	cellular_component	Prp19 complex
L	0000977	molecular_function	RNA polymerase II transcription regulatory region sequence-specific DNA binding
L	0000981	molecular_function	DNA-binding transcription factor activity, RNA polymerase II-specific
L	0001228	molecular_function	DNA-binding transcription activator activity, RNA polymerase II-specific
L	0003677	molecular_function	DNA binding
L	0003723	molecular_function	RNA binding
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005662	cellular_component	DNA replication factor A complex
L	0005681	cellular_component	spliceosomal complex
L	0005737	cellular_component	cytoplasm
L	0006281	biological_process	DNA repair
L	0006357	biological_process	regulation of transcription by RNA polymerase II
L	0006397	biological_process	mRNA processing
L	0006974	biological_process	DNA damage response
L	0007049	biological_process	cell cycle
L	0008380	biological_process	RNA splicing
L	0016020	cellular_component	membrane
L	0016607	cellular_component	nuclear speck
L	0042802	molecular_function	identical protein binding
L	0045944	biological_process	positive regulation of transcription by RNA polymerase II
L	0071007	cellular_component	U2-type catalytic step 2 spliceosome
L	0071013	cellular_component	catalytic step 2 spliceosome
L	0071987	molecular_function	WD40-repeat domain binding
M	0000398	biological_process	mRNA splicing, via spliceosome
M	0000974	cellular_component	Prp19 complex
M	0001701	biological_process	in utero embryonic development
M	0003723	molecular_function	RNA binding
M	0005515	molecular_function	protein binding
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005681	cellular_component	spliceosomal complex
M	0006397	biological_process	mRNA processing
M	0007095	biological_process	mitotic G2 DNA damage checkpoint signaling
M	0007369	biological_process	gastrulation
M	0008284	biological_process	positive regulation of cell population proliferation
M	0008380	biological_process	RNA splicing
M	0016607	cellular_component	nuclear speck
M	0048568	biological_process	embryonic organ development
M	0071007	cellular_component	U2-type catalytic step 2 spliceosome
M	0071013	cellular_component	catalytic step 2 spliceosome
M	0071014	cellular_component	post-mRNA release spliceosomal complex
N	0000398	biological_process	mRNA splicing, via spliceosome
N	0000785	cellular_component	chromatin
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005681	cellular_component	spliceosomal complex
N	0006397	biological_process	mRNA processing
N	0008380	biological_process	RNA splicing
N	0016922	molecular_function	nuclear receptor binding
N	0030374	molecular_function	nuclear receptor coactivator activity
N	0045893	biological_process	positive regulation of DNA-templated transcription
N	0071007	cellular_component	U2-type catalytic step 2 spliceosome
N	2000825	biological_process	positive regulation of androgen receptor activity
O	0000398	biological_process	mRNA splicing, via spliceosome
O	0000974	cellular_component	Prp19 complex
O	0003676	molecular_function	nucleic acid binding
O	0003723	molecular_function	RNA binding
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005681	cellular_component	spliceosomal complex
O	0005737	cellular_component	cytoplasm
O	0006397	biological_process	mRNA processing
O	0008380	biological_process	RNA splicing
O	0017070	molecular_function	U6 snRNA binding
O	0033120	biological_process	positive regulation of RNA splicing
O	0036002	molecular_function	pre-mRNA binding
O	0042307	biological_process	positive regulation of protein import into nucleus
O	0045292	biological_process	mRNA cis splicing, via spliceosome
O	0046827	biological_process	positive regulation of protein export from nucleus
O	0046872	molecular_function	metal ion binding
O	0048306	molecular_function	calcium-dependent protein binding
O	0071006	cellular_component	U2-type catalytic step 1 spliceosome
O	0071007	cellular_component	U2-type catalytic step 2 spliceosome
O	0071013	cellular_component	catalytic step 2 spliceosome
O	0071466	biological_process	cellular response to xenobiotic stimulus
P	0000398	biological_process	mRNA splicing, via spliceosome
P	0000974	cellular_component	Prp19 complex
P	0003723	molecular_function	RNA binding
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005681	cellular_component	spliceosomal complex
P	0005739	cellular_component	mitochondrion
P	0006397	biological_process	mRNA processing
P	0008380	biological_process	RNA splicing
P	0016607	cellular_component	nuclear speck
P	0045292	biological_process	mRNA cis splicing, via spliceosome
P	0071007	cellular_component	U2-type catalytic step 2 spliceosome
P	0071013	cellular_component	catalytic step 2 spliceosome
Q	0000166	molecular_function	nucleotide binding
Q	0000398	biological_process	mRNA splicing, via spliceosome
Q	0003723	molecular_function	RNA binding
Q	0003724	molecular_function	RNA helicase activity
Q	0003727	molecular_function	single-stranded RNA binding
Q	0003729	molecular_function	mRNA binding
Q	0004386	molecular_function	helicase activity
Q	0005515	molecular_function	protein binding
Q	0005524	molecular_function	ATP binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005681	cellular_component	spliceosomal complex
Q	0006397	biological_process	mRNA processing
Q	0008380	biological_process	RNA splicing
Q	0016020	cellular_component	membrane
Q	0016787	molecular_function	hydrolase activity
Q	0016887	molecular_function	ATP hydrolysis activity
Q	0034458	molecular_function	3'-5' RNA helicase activity
Q	0071007	cellular_component	U2-type catalytic step 2 spliceosome
Q	0071013	cellular_component	catalytic step 2 spliceosome
R	0000122	biological_process	negative regulation of transcription by RNA polymerase II
R	0000398	biological_process	mRNA splicing, via spliceosome
R	0003713	molecular_function	transcription coactivator activity
R	0003714	molecular_function	transcription corepressor activity
R	0003723	molecular_function	RNA binding
R	0005112	molecular_function	Notch binding
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005681	cellular_component	spliceosomal complex
R	0006357	biological_process	regulation of transcription by RNA polymerase II
R	0006397	biological_process	mRNA processing
R	0008024	cellular_component	cyclin/CDK positive transcription elongation factor complex
R	0008380	biological_process	RNA splicing
R	0016363	cellular_component	nuclear matrix
R	0016604	cellular_component	nuclear body
R	0016607	cellular_component	nuclear speck
R	0016922	molecular_function	nuclear receptor binding
R	0019899	molecular_function	enzyme binding
R	0030511	biological_process	positive regulation of transforming growth factor beta receptor signaling pathway
R	0042771	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
R	0042809	molecular_function	nuclear vitamin D receptor binding
R	0042974	molecular_function	nuclear retinoic acid receptor binding
R	0043923	biological_process	positive regulation by host of viral transcription
R	0045892	biological_process	negative regulation of DNA-templated transcription
R	0045944	biological_process	positive regulation of transcription by RNA polymerase II
R	0046332	molecular_function	SMAD binding
R	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
R	0048384	biological_process	retinoic acid receptor signaling pathway
R	0048385	biological_process	regulation of retinoic acid receptor signaling pathway
R	0050681	molecular_function	nuclear androgen receptor binding
R	0050769	biological_process	positive regulation of neurogenesis
R	0070562	biological_process	regulation of vitamin D receptor signaling pathway
R	0070564	biological_process	positive regulation of vitamin D receptor signaling pathway
R	0071007	cellular_component	U2-type catalytic step 2 spliceosome
R	0071013	cellular_component	catalytic step 2 spliceosome
R	0071300	biological_process	cellular response to retinoic acid
S	0000398	biological_process	mRNA splicing, via spliceosome
S	0000413	biological_process	protein peptidyl-prolyl isomerization
S	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005681	cellular_component	spliceosomal complex
S	0006397	biological_process	mRNA processing
S	0006457	biological_process	protein folding
S	0008380	biological_process	RNA splicing
S	0016018	molecular_function	cyclosporin A binding
S	0016853	molecular_function	isomerase activity
S	0071007	cellular_component	U2-type catalytic step 2 spliceosome
S	0071013	cellular_component	catalytic step 2 spliceosome
S	0097718	molecular_function	disordered domain specific binding
S	1990403	biological_process	embryonic brain development
T	0000398	biological_process	mRNA splicing, via spliceosome
T	0000974	cellular_component	Prp19 complex
T	0001650	cellular_component	fibrillar center
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005662	cellular_component	DNA replication factor A complex
T	0005681	cellular_component	spliceosomal complex
T	0006397	biological_process	mRNA processing
T	0008380	biological_process	RNA splicing
T	0016607	cellular_component	nuclear speck
T	0031965	cellular_component	nuclear membrane
T	0034504	biological_process	protein localization to nucleus
T	0071007	cellular_component	U2-type catalytic step 2 spliceosome
T	0071011	cellular_component	precatalytic spliceosome
T	0071013	cellular_component	catalytic step 2 spliceosome
T	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle
U	0000398	biological_process	mRNA splicing, via spliceosome
U	0005515	molecular_function	protein binding
U	0005654	cellular_component	nucleoplasm
U	0071014	cellular_component	post-mRNA release spliceosomal complex
V	0000166	molecular_function	nucleotide binding
V	0000398	biological_process	mRNA splicing, via spliceosome
V	0002376	biological_process	immune system process
V	0003676	molecular_function	nucleic acid binding
V	0003723	molecular_function	RNA binding
V	0003724	molecular_function	RNA helicase activity
V	0003725	molecular_function	double-stranded RNA binding
V	0004386	molecular_function	helicase activity
V	0005515	molecular_function	protein binding
V	0005524	molecular_function	ATP binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005681	cellular_component	spliceosomal complex
V	0005689	cellular_component	U12-type spliceosomal complex
V	0005730	cellular_component	nucleolus
V	0006397	biological_process	mRNA processing
V	0008186	molecular_function	ATP-dependent activity, acting on RNA
V	0008380	biological_process	RNA splicing
V	0009636	biological_process	response to toxic substance
V	0016607	cellular_component	nuclear speck
V	0016787	molecular_function	hydrolase activity
V	0016887	molecular_function	ATP hydrolysis activity
V	0042742	biological_process	defense response to bacterium
V	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
V	0043279	biological_process	response to alkaloid
V	0045087	biological_process	innate immune response
V	0051607	biological_process	defense response to virus
V	0071008	cellular_component	U2-type post-mRNA release spliceosomal complex
V	0140374	biological_process	antiviral innate immune response
W	0000398	biological_process	mRNA splicing, via spliceosome
W	0003723	molecular_function	RNA binding
W	0003729	molecular_function	mRNA binding
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005681	cellular_component	spliceosomal complex
W	0006397	biological_process	mRNA processing
W	0008380	biological_process	RNA splicing
W	0016607	cellular_component	nuclear speck
W	0071007	cellular_component	U2-type catalytic step 2 spliceosome
W	0071013	cellular_component	catalytic step 2 spliceosome
W	1990403	biological_process	embryonic brain development
a	0000243	cellular_component	commitment complex
a	0000387	biological_process	spliceosomal snRNP assembly
a	0000398	biological_process	mRNA splicing, via spliceosome
a	0003723	molecular_function	RNA binding
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005654	cellular_component	nucleoplasm
a	0005681	cellular_component	spliceosomal complex
a	0005682	cellular_component	U5 snRNP
a	0005683	cellular_component	U7 snRNP
a	0005684	cellular_component	U2-type spliceosomal complex
a	0005685	cellular_component	U1 snRNP
a	0005686	cellular_component	U2 snRNP
a	0005687	cellular_component	U4 snRNP
a	0005689	cellular_component	U12-type spliceosomal complex
a	0005697	cellular_component	telomerase holoenzyme complex
a	0005737	cellular_component	cytoplasm
a	0005829	cellular_component	cytosol
a	0006396	biological_process	RNA processing
a	0006397	biological_process	mRNA processing
a	0006479	biological_process	protein methylation
a	0008380	biological_process	RNA splicing
a	0016604	cellular_component	nuclear body
a	0019899	molecular_function	enzyme binding
a	0030532	cellular_component	small nuclear ribonucleoprotein complex
a	0034709	cellular_component	methylosome
a	0034715	cellular_component	pICln-Sm protein complex
a	0034719	cellular_component	SMN-Sm protein complex
a	0036261	biological_process	7-methylguanosine cap hypermethylation
a	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
a	0070034	molecular_function	telomerase RNA binding
a	0071005	cellular_component	U2-type precatalytic spliceosome
a	0071007	cellular_component	U2-type catalytic step 2 spliceosome
a	0071011	cellular_component	precatalytic spliceosome
a	0071013	cellular_component	catalytic step 2 spliceosome
a	0071208	molecular_function	histone pre-mRNA DCP binding
a	0071209	molecular_function	U7 snRNA binding
a	0097526	cellular_component	spliceosomal tri-snRNP complex
a	1903241	biological_process	U2-type prespliceosome assembly
a	1990446	molecular_function	U1 snRNP binding
a	1990904	cellular_component	ribonucleoprotein complex
b	0000387	biological_process	spliceosomal snRNP assembly
b	0000398	biological_process	mRNA splicing, via spliceosome
b	0003723	molecular_function	RNA binding
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005654	cellular_component	nucleoplasm
b	0005681	cellular_component	spliceosomal complex
b	0005682	cellular_component	U5 snRNP
b	0005683	cellular_component	U7 snRNP
b	0005684	cellular_component	U2-type spliceosomal complex
b	0005685	cellular_component	U1 snRNP
b	0005686	cellular_component	U2 snRNP
b	0005687	cellular_component	U4 snRNP
b	0005689	cellular_component	U12-type spliceosomal complex
b	0005697	cellular_component	telomerase holoenzyme complex
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0006397	biological_process	mRNA processing
b	0006479	biological_process	protein methylation
b	0008380	biological_process	RNA splicing
b	0030532	cellular_component	small nuclear ribonucleoprotein complex
b	0034709	cellular_component	methylosome
b	0034719	cellular_component	SMN-Sm protein complex
b	0036261	biological_process	7-methylguanosine cap hypermethylation
b	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
b	0070034	molecular_function	telomerase RNA binding
b	0071004	cellular_component	U2-type prespliceosome
b	0071005	cellular_component	U2-type precatalytic spliceosome
b	0071007	cellular_component	U2-type catalytic step 2 spliceosome
b	0071013	cellular_component	catalytic step 2 spliceosome
b	0071204	cellular_component	histone pre-mRNA 3'end processing complex
b	0071208	molecular_function	histone pre-mRNA DCP binding
b	1903241	biological_process	U2-type prespliceosome assembly
b	1990446	molecular_function	U1 snRNP binding
b	1990447	molecular_function	U2 snRNP binding
b	1990904	cellular_component	ribonucleoprotein complex
c	0000243	cellular_component	commitment complex
c	0000245	biological_process	spliceosomal complex assembly
c	0000387	biological_process	spliceosomal snRNP assembly
c	0000398	biological_process	mRNA splicing, via spliceosome
c	0003723	molecular_function	RNA binding
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005654	cellular_component	nucleoplasm
c	0005681	cellular_component	spliceosomal complex
c	0005682	cellular_component	U5 snRNP
c	0005684	cellular_component	U2-type spliceosomal complex
c	0005685	cellular_component	U1 snRNP
c	0005686	cellular_component	U2 snRNP
c	0005687	cellular_component	U4 snRNP
c	0005689	cellular_component	U12-type spliceosomal complex
c	0005737	cellular_component	cytoplasm
c	0005829	cellular_component	cytosol
c	0006396	biological_process	RNA processing
c	0006397	biological_process	mRNA processing
c	0008380	biological_process	RNA splicing
c	0030532	cellular_component	small nuclear ribonucleoprotein complex
c	0034709	cellular_component	methylosome
c	0034715	cellular_component	pICln-Sm protein complex
c	0034719	cellular_component	SMN-Sm protein complex
c	0036261	biological_process	7-methylguanosine cap hypermethylation
c	0043229	cellular_component	intracellular organelle
c	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
c	0071005	cellular_component	U2-type precatalytic spliceosome
c	0071007	cellular_component	U2-type catalytic step 2 spliceosome
c	0071011	cellular_component	precatalytic spliceosome
c	0071013	cellular_component	catalytic step 2 spliceosome
c	0097526	cellular_component	spliceosomal tri-snRNP complex
c	1903241	biological_process	U2-type prespliceosome assembly
c	1990904	cellular_component	ribonucleoprotein complex
d	0000245	biological_process	spliceosomal complex assembly
d	0000387	biological_process	spliceosomal snRNP assembly
d	0000398	biological_process	mRNA splicing, via spliceosome
d	0003723	molecular_function	RNA binding
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005654	cellular_component	nucleoplasm
d	0005681	cellular_component	spliceosomal complex
d	0005682	cellular_component	U5 snRNP
d	0005684	cellular_component	U2-type spliceosomal complex
d	0005685	cellular_component	U1 snRNP
d	0005686	cellular_component	U2 snRNP
d	0005687	cellular_component	U4 snRNP
d	0005689	cellular_component	U12-type spliceosomal complex
d	0005737	cellular_component	cytoplasm
d	0005829	cellular_component	cytosol
d	0006397	biological_process	mRNA processing
d	0008380	biological_process	RNA splicing
d	0030532	cellular_component	small nuclear ribonucleoprotein complex
d	0034709	cellular_component	methylosome
d	0034715	cellular_component	pICln-Sm protein complex
d	0034719	cellular_component	SMN-Sm protein complex
d	0036261	biological_process	7-methylguanosine cap hypermethylation
d	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
d	0070062	cellular_component	extracellular exosome
d	0071005	cellular_component	U2-type precatalytic spliceosome
d	0071007	cellular_component	U2-type catalytic step 2 spliceosome
d	0071011	cellular_component	precatalytic spliceosome
d	0071013	cellular_component	catalytic step 2 spliceosome
d	1903241	biological_process	U2-type prespliceosome assembly
d	1990904	cellular_component	ribonucleoprotein complex
e	0000245	biological_process	spliceosomal complex assembly
e	0000387	biological_process	spliceosomal snRNP assembly
e	0000398	biological_process	mRNA splicing, via spliceosome
e	0003723	molecular_function	RNA binding
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005654	cellular_component	nucleoplasm
e	0005681	cellular_component	spliceosomal complex
e	0005682	cellular_component	U5 snRNP
e	0005683	cellular_component	U7 snRNP
e	0005684	cellular_component	U2-type spliceosomal complex
e	0005685	cellular_component	U1 snRNP
e	0005686	cellular_component	U2 snRNP
e	0005687	cellular_component	U4 snRNP
e	0005689	cellular_component	U12-type spliceosomal complex
e	0005697	cellular_component	telomerase holoenzyme complex
e	0005737	cellular_component	cytoplasm
e	0005829	cellular_component	cytosol
e	0006397	biological_process	mRNA processing
e	0008380	biological_process	RNA splicing
e	0030532	cellular_component	small nuclear ribonucleoprotein complex
e	0034709	cellular_component	methylosome
e	0034715	cellular_component	pICln-Sm protein complex
e	0034719	cellular_component	SMN-Sm protein complex
e	0036261	biological_process	7-methylguanosine cap hypermethylation
e	0043229	cellular_component	intracellular organelle
e	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
e	0071005	cellular_component	U2-type precatalytic spliceosome
e	0071007	cellular_component	U2-type catalytic step 2 spliceosome
e	0071011	cellular_component	precatalytic spliceosome
e	0071013	cellular_component	catalytic step 2 spliceosome
e	1903241	biological_process	U2-type prespliceosome assembly
e	1990904	cellular_component	ribonucleoprotein complex
f	0000387	biological_process	spliceosomal snRNP assembly
f	0000398	biological_process	mRNA splicing, via spliceosome
f	0003723	molecular_function	RNA binding
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005654	cellular_component	nucleoplasm
f	0005681	cellular_component	spliceosomal complex
f	0005682	cellular_component	U5 snRNP
f	0005683	cellular_component	U7 snRNP
f	0005684	cellular_component	U2-type spliceosomal complex
f	0005685	cellular_component	U1 snRNP
f	0005686	cellular_component	U2 snRNP
f	0005687	cellular_component	U4 snRNP
f	0005689	cellular_component	U12-type spliceosomal complex
f	0005737	cellular_component	cytoplasm
f	0005829	cellular_component	cytosol
f	0006397	biological_process	mRNA processing
f	0008380	biological_process	RNA splicing
f	0030532	cellular_component	small nuclear ribonucleoprotein complex
f	0034709	cellular_component	methylosome
f	0034715	cellular_component	pICln-Sm protein complex
f	0034719	cellular_component	SMN-Sm protein complex
f	0036261	biological_process	7-methylguanosine cap hypermethylation
f	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
f	0071005	cellular_component	U2-type precatalytic spliceosome
f	0071007	cellular_component	U2-type catalytic step 2 spliceosome
f	0071013	cellular_component	catalytic step 2 spliceosome
f	0120114	cellular_component	Sm-like protein family complex
f	1903241	biological_process	U2-type prespliceosome assembly
f	1990904	cellular_component	ribonucleoprotein complex
g	0000245	biological_process	spliceosomal complex assembly
g	0000387	biological_process	spliceosomal snRNP assembly
g	0000398	biological_process	mRNA splicing, via spliceosome
g	0003723	molecular_function	RNA binding
g	0005515	molecular_function	protein binding
g	0005634	cellular_component	nucleus
g	0005654	cellular_component	nucleoplasm
g	0005681	cellular_component	spliceosomal complex
g	0005682	cellular_component	U5 snRNP
g	0005683	cellular_component	U7 snRNP
g	0005684	cellular_component	U2-type spliceosomal complex
g	0005685	cellular_component	U1 snRNP
g	0005686	cellular_component	U2 snRNP
g	0005687	cellular_component	U4 snRNP
g	0005689	cellular_component	U12-type spliceosomal complex
g	0005737	cellular_component	cytoplasm
g	0005829	cellular_component	cytosol
g	0006397	biological_process	mRNA processing
g	0008380	biological_process	RNA splicing
g	0030532	cellular_component	small nuclear ribonucleoprotein complex
g	0034709	cellular_component	methylosome
g	0034719	cellular_component	SMN-Sm protein complex
g	0036261	biological_process	7-methylguanosine cap hypermethylation
g	0043186	cellular_component	P granule
g	0043229	cellular_component	intracellular organelle
g	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
g	0071004	cellular_component	U2-type prespliceosome
g	0071005	cellular_component	U2-type precatalytic spliceosome
g	0071007	cellular_component	U2-type catalytic step 2 spliceosome
g	0071011	cellular_component	precatalytic spliceosome
g	0071013	cellular_component	catalytic step 2 spliceosome
g	0097526	cellular_component	spliceosomal tri-snRNP complex
g	1903241	biological_process	U2-type prespliceosome assembly
g	1990904	cellular_component	ribonucleoprotein complex
h	0000243	cellular_component	commitment complex
h	0000387	biological_process	spliceosomal snRNP assembly
h	0000398	biological_process	mRNA splicing, via spliceosome
h	0003723	molecular_function	RNA binding
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005654	cellular_component	nucleoplasm
h	0005681	cellular_component	spliceosomal complex
h	0005682	cellular_component	U5 snRNP
h	0005683	cellular_component	U7 snRNP
h	0005684	cellular_component	U2-type spliceosomal complex
h	0005685	cellular_component	U1 snRNP
h	0005686	cellular_component	U2 snRNP
h	0005687	cellular_component	U4 snRNP
h	0005689	cellular_component	U12-type spliceosomal complex
h	0005697	cellular_component	telomerase holoenzyme complex
h	0005737	cellular_component	cytoplasm
h	0005829	cellular_component	cytosol
h	0006396	biological_process	RNA processing
h	0006397	biological_process	mRNA processing
h	0006479	biological_process	protein methylation
h	0008380	biological_process	RNA splicing
h	0016604	cellular_component	nuclear body
h	0019899	molecular_function	enzyme binding
h	0030532	cellular_component	small nuclear ribonucleoprotein complex
h	0034709	cellular_component	methylosome
h	0034715	cellular_component	pICln-Sm protein complex
h	0034719	cellular_component	SMN-Sm protein complex
h	0036261	biological_process	7-methylguanosine cap hypermethylation
h	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
h	0070034	molecular_function	telomerase RNA binding
h	0071005	cellular_component	U2-type precatalytic spliceosome
h	0071007	cellular_component	U2-type catalytic step 2 spliceosome
h	0071011	cellular_component	precatalytic spliceosome
h	0071013	cellular_component	catalytic step 2 spliceosome
h	0071208	molecular_function	histone pre-mRNA DCP binding
h	0071209	molecular_function	U7 snRNA binding
h	0097526	cellular_component	spliceosomal tri-snRNP complex
h	1903241	biological_process	U2-type prespliceosome assembly
h	1990446	molecular_function	U1 snRNP binding
h	1990904	cellular_component	ribonucleoprotein complex
i	0000387	biological_process	spliceosomal snRNP assembly
i	0000398	biological_process	mRNA splicing, via spliceosome
i	0003723	molecular_function	RNA binding
i	0005515	molecular_function	protein binding
i	0005634	cellular_component	nucleus
i	0005654	cellular_component	nucleoplasm
i	0005681	cellular_component	spliceosomal complex
i	0005682	cellular_component	U5 snRNP
i	0005683	cellular_component	U7 snRNP
i	0005684	cellular_component	U2-type spliceosomal complex
i	0005685	cellular_component	U1 snRNP
i	0005686	cellular_component	U2 snRNP
i	0005687	cellular_component	U4 snRNP
i	0005689	cellular_component	U12-type spliceosomal complex
i	0005697	cellular_component	telomerase holoenzyme complex
i	0005737	cellular_component	cytoplasm
i	0005829	cellular_component	cytosol
i	0006397	biological_process	mRNA processing
i	0006479	biological_process	protein methylation
i	0008380	biological_process	RNA splicing
i	0030532	cellular_component	small nuclear ribonucleoprotein complex
i	0034709	cellular_component	methylosome
i	0034719	cellular_component	SMN-Sm protein complex
i	0036261	biological_process	7-methylguanosine cap hypermethylation
i	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
i	0070034	molecular_function	telomerase RNA binding
i	0071004	cellular_component	U2-type prespliceosome
i	0071005	cellular_component	U2-type precatalytic spliceosome
i	0071007	cellular_component	U2-type catalytic step 2 spliceosome
i	0071013	cellular_component	catalytic step 2 spliceosome
i	0071204	cellular_component	histone pre-mRNA 3'end processing complex
i	0071208	molecular_function	histone pre-mRNA DCP binding
i	1903241	biological_process	U2-type prespliceosome assembly
i	1990446	molecular_function	U1 snRNP binding
i	1990447	molecular_function	U2 snRNP binding
i	1990904	cellular_component	ribonucleoprotein complex
j	0000243	cellular_component	commitment complex
j	0000245	biological_process	spliceosomal complex assembly
j	0000387	biological_process	spliceosomal snRNP assembly
j	0000398	biological_process	mRNA splicing, via spliceosome
j	0003723	molecular_function	RNA binding
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005654	cellular_component	nucleoplasm
j	0005681	cellular_component	spliceosomal complex
j	0005682	cellular_component	U5 snRNP
j	0005684	cellular_component	U2-type spliceosomal complex
j	0005685	cellular_component	U1 snRNP
j	0005686	cellular_component	U2 snRNP
j	0005687	cellular_component	U4 snRNP
j	0005689	cellular_component	U12-type spliceosomal complex
j	0005737	cellular_component	cytoplasm
j	0005829	cellular_component	cytosol
j	0006396	biological_process	RNA processing
j	0006397	biological_process	mRNA processing
j	0008380	biological_process	RNA splicing
j	0030532	cellular_component	small nuclear ribonucleoprotein complex
j	0034709	cellular_component	methylosome
j	0034715	cellular_component	pICln-Sm protein complex
j	0034719	cellular_component	SMN-Sm protein complex
j	0036261	biological_process	7-methylguanosine cap hypermethylation
j	0043229	cellular_component	intracellular organelle
j	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
j	0071005	cellular_component	U2-type precatalytic spliceosome
j	0071007	cellular_component	U2-type catalytic step 2 spliceosome
j	0071011	cellular_component	precatalytic spliceosome
j	0071013	cellular_component	catalytic step 2 spliceosome
j	0097526	cellular_component	spliceosomal tri-snRNP complex
j	1903241	biological_process	U2-type prespliceosome assembly
j	1990904	cellular_component	ribonucleoprotein complex
k	0000245	biological_process	spliceosomal complex assembly
k	0000387	biological_process	spliceosomal snRNP assembly
k	0000398	biological_process	mRNA splicing, via spliceosome
k	0003723	molecular_function	RNA binding
k	0005515	molecular_function	protein binding
k	0005634	cellular_component	nucleus
k	0005654	cellular_component	nucleoplasm
k	0005681	cellular_component	spliceosomal complex
k	0005682	cellular_component	U5 snRNP
k	0005684	cellular_component	U2-type spliceosomal complex
k	0005685	cellular_component	U1 snRNP
k	0005686	cellular_component	U2 snRNP
k	0005687	cellular_component	U4 snRNP
k	0005689	cellular_component	U12-type spliceosomal complex
k	0005737	cellular_component	cytoplasm
k	0005829	cellular_component	cytosol
k	0006397	biological_process	mRNA processing
k	0008380	biological_process	RNA splicing
k	0030532	cellular_component	small nuclear ribonucleoprotein complex
k	0034709	cellular_component	methylosome
k	0034715	cellular_component	pICln-Sm protein complex
k	0034719	cellular_component	SMN-Sm protein complex
k	0036261	biological_process	7-methylguanosine cap hypermethylation
k	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
k	0070062	cellular_component	extracellular exosome
k	0071005	cellular_component	U2-type precatalytic spliceosome
k	0071007	cellular_component	U2-type catalytic step 2 spliceosome
k	0071011	cellular_component	precatalytic spliceosome
k	0071013	cellular_component	catalytic step 2 spliceosome
k	1903241	biological_process	U2-type prespliceosome assembly
k	1990904	cellular_component	ribonucleoprotein complex
l	0000245	biological_process	spliceosomal complex assembly
l	0000387	biological_process	spliceosomal snRNP assembly
l	0000398	biological_process	mRNA splicing, via spliceosome
l	0003723	molecular_function	RNA binding
l	0005515	molecular_function	protein binding
l	0005634	cellular_component	nucleus
l	0005654	cellular_component	nucleoplasm
l	0005681	cellular_component	spliceosomal complex
l	0005682	cellular_component	U5 snRNP
l	0005683	cellular_component	U7 snRNP
l	0005684	cellular_component	U2-type spliceosomal complex
l	0005685	cellular_component	U1 snRNP
l	0005686	cellular_component	U2 snRNP
l	0005687	cellular_component	U4 snRNP
l	0005689	cellular_component	U12-type spliceosomal complex
l	0005697	cellular_component	telomerase holoenzyme complex
l	0005737	cellular_component	cytoplasm
l	0005829	cellular_component	cytosol
l	0006397	biological_process	mRNA processing
l	0008380	biological_process	RNA splicing
l	0030532	cellular_component	small nuclear ribonucleoprotein complex
l	0034709	cellular_component	methylosome
l	0034715	cellular_component	pICln-Sm protein complex
l	0034719	cellular_component	SMN-Sm protein complex
l	0036261	biological_process	7-methylguanosine cap hypermethylation
l	0043229	cellular_component	intracellular organelle
l	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
l	0071005	cellular_component	U2-type precatalytic spliceosome
l	0071007	cellular_component	U2-type catalytic step 2 spliceosome
l	0071011	cellular_component	precatalytic spliceosome
l	0071013	cellular_component	catalytic step 2 spliceosome
l	1903241	biological_process	U2-type prespliceosome assembly
l	1990904	cellular_component	ribonucleoprotein complex
m	0000387	biological_process	spliceosomal snRNP assembly
m	0000398	biological_process	mRNA splicing, via spliceosome
m	0003723	molecular_function	RNA binding
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005654	cellular_component	nucleoplasm
m	0005681	cellular_component	spliceosomal complex
m	0005682	cellular_component	U5 snRNP
m	0005683	cellular_component	U7 snRNP
m	0005684	cellular_component	U2-type spliceosomal complex
m	0005685	cellular_component	U1 snRNP
m	0005686	cellular_component	U2 snRNP
m	0005687	cellular_component	U4 snRNP
m	0005689	cellular_component	U12-type spliceosomal complex
m	0005737	cellular_component	cytoplasm
m	0005829	cellular_component	cytosol
m	0006397	biological_process	mRNA processing
m	0008380	biological_process	RNA splicing
m	0030532	cellular_component	small nuclear ribonucleoprotein complex
m	0034709	cellular_component	methylosome
m	0034715	cellular_component	pICln-Sm protein complex
m	0034719	cellular_component	SMN-Sm protein complex
m	0036261	biological_process	7-methylguanosine cap hypermethylation
m	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
m	0071005	cellular_component	U2-type precatalytic spliceosome
m	0071007	cellular_component	U2-type catalytic step 2 spliceosome
m	0071013	cellular_component	catalytic step 2 spliceosome
m	0120114	cellular_component	Sm-like protein family complex
m	1903241	biological_process	U2-type prespliceosome assembly
m	1990904	cellular_component	ribonucleoprotein complex
n	0000245	biological_process	spliceosomal complex assembly
n	0000387	biological_process	spliceosomal snRNP assembly
n	0000398	biological_process	mRNA splicing, via spliceosome
n	0003723	molecular_function	RNA binding
n	0005515	molecular_function	protein binding
n	0005634	cellular_component	nucleus
n	0005654	cellular_component	nucleoplasm
n	0005681	cellular_component	spliceosomal complex
n	0005682	cellular_component	U5 snRNP
n	0005683	cellular_component	U7 snRNP
n	0005684	cellular_component	U2-type spliceosomal complex
n	0005685	cellular_component	U1 snRNP
n	0005686	cellular_component	U2 snRNP
n	0005687	cellular_component	U4 snRNP
n	0005689	cellular_component	U12-type spliceosomal complex
n	0005737	cellular_component	cytoplasm
n	0005829	cellular_component	cytosol
n	0006397	biological_process	mRNA processing
n	0008380	biological_process	RNA splicing
n	0030532	cellular_component	small nuclear ribonucleoprotein complex
n	0034709	cellular_component	methylosome
n	0034719	cellular_component	SMN-Sm protein complex
n	0036261	biological_process	7-methylguanosine cap hypermethylation
n	0043186	cellular_component	P granule
n	0043229	cellular_component	intracellular organelle
n	0046540	cellular_component	U4/U6 x U5 tri-snRNP complex
n	0071004	cellular_component	U2-type prespliceosome
n	0071005	cellular_component	U2-type precatalytic spliceosome
n	0071007	cellular_component	U2-type catalytic step 2 spliceosome
n	0071011	cellular_component	precatalytic spliceosome
n	0071013	cellular_component	catalytic step 2 spliceosome
n	0097526	cellular_component	spliceosomal tri-snRNP complex
n	1903241	biological_process	U2-type prespliceosome assembly
n	1990904	cellular_component	ribonucleoprotein complex
o	0000398	biological_process	mRNA splicing, via spliceosome
o	0003723	molecular_function	RNA binding
o	0005515	molecular_function	protein binding
o	0005634	cellular_component	nucleus
o	0005654	cellular_component	nucleoplasm
o	0005681	cellular_component	spliceosomal complex
o	0005684	cellular_component	U2-type spliceosomal complex
o	0005686	cellular_component	U2 snRNP
o	0006397	biological_process	mRNA processing
o	0007283	biological_process	spermatogenesis
o	0008380	biological_process	RNA splicing
o	0016604	cellular_component	nuclear body
o	0016607	cellular_component	nuclear speck
o	0030532	cellular_component	small nuclear ribonucleoprotein complex
o	0030620	molecular_function	U2 snRNA binding
o	0071005	cellular_component	U2-type precatalytic spliceosome
o	0071007	cellular_component	U2-type catalytic step 2 spliceosome
o	0071013	cellular_component	catalytic step 2 spliceosome
o	1903241	biological_process	U2-type prespliceosome assembly
o	1990904	cellular_component	ribonucleoprotein complex
p	0000398	biological_process	mRNA splicing, via spliceosome
p	0001650	cellular_component	fibrillar center
p	0003676	molecular_function	nucleic acid binding
p	0003723	molecular_function	RNA binding
p	0005515	molecular_function	protein binding
p	0005634	cellular_component	nucleus
p	0005654	cellular_component	nucleoplasm
p	0005681	cellular_component	spliceosomal complex
p	0005684	cellular_component	U2-type spliceosomal complex
p	0005685	cellular_component	U1 snRNP
p	0005686	cellular_component	U2 snRNP
p	0006397	biological_process	mRNA processing
p	0008380	biological_process	RNA splicing
p	0016607	cellular_component	nuclear speck
p	0030619	molecular_function	U1 snRNA binding
p	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
p	0071005	cellular_component	U2-type precatalytic spliceosome
p	0071007	cellular_component	U2-type catalytic step 2 spliceosome
p	0071013	cellular_component	catalytic step 2 spliceosome
p	1903241	biological_process	U2-type prespliceosome assembly
p	1990904	cellular_component	ribonucleoprotein complex
q	0000077	biological_process	DNA damage checkpoint signaling
q	0000209	biological_process	protein polyubiquitination
q	0000244	biological_process	spliceosomal tri-snRNP complex assembly
q	0000245	biological_process	spliceosomal complex assembly
q	0000398	biological_process	mRNA splicing, via spliceosome
q	0000974	cellular_component	Prp19 complex
q	0004842	molecular_function	ubiquitin-protein transferase activity
q	0005515	molecular_function	protein binding
q	0005634	cellular_component	nucleus
q	0005654	cellular_component	nucleoplasm
q	0005662	cellular_component	DNA replication factor A complex
q	0005681	cellular_component	spliceosomal complex
q	0005737	cellular_component	cytoplasm
q	0005811	cellular_component	lipid droplet
q	0005819	cellular_component	spindle
q	0005856	cellular_component	cytoskeleton
q	0006281	biological_process	DNA repair
q	0006303	biological_process	double-strand break repair via nonhomologous end joining
q	0006397	biological_process	mRNA processing
q	0006974	biological_process	DNA damage response
q	0008104	biological_process	protein localization
q	0008380	biological_process	RNA splicing
q	0008610	biological_process	lipid biosynthetic process
q	0010498	biological_process	proteasomal protein catabolic process
q	0016020	cellular_component	membrane
q	0016567	biological_process	protein ubiquitination
q	0016607	cellular_component	nuclear speck
q	0016740	molecular_function	transferase activity
q	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
q	0035861	cellular_component	site of double-strand break
q	0042802	molecular_function	identical protein binding
q	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
q	0061630	molecular_function	ubiquitin protein ligase activity
q	0070534	biological_process	protein K63-linked ubiquitination
q	0071006	cellular_component	U2-type catalytic step 1 spliceosome
q	0071007	cellular_component	U2-type catalytic step 2 spliceosome
q	0071013	cellular_component	catalytic step 2 spliceosome
r	0000077	biological_process	DNA damage checkpoint signaling
r	0000209	biological_process	protein polyubiquitination
r	0000244	biological_process	spliceosomal tri-snRNP complex assembly
r	0000245	biological_process	spliceosomal complex assembly
r	0000398	biological_process	mRNA splicing, via spliceosome
r	0000974	cellular_component	Prp19 complex
r	0004842	molecular_function	ubiquitin-protein transferase activity
r	0005515	molecular_function	protein binding
r	0005634	cellular_component	nucleus
r	0005654	cellular_component	nucleoplasm
r	0005662	cellular_component	DNA replication factor A complex
r	0005681	cellular_component	spliceosomal complex
r	0005737	cellular_component	cytoplasm
r	0005811	cellular_component	lipid droplet
r	0005819	cellular_component	spindle
r	0005856	cellular_component	cytoskeleton
r	0006281	biological_process	DNA repair
r	0006303	biological_process	double-strand break repair via nonhomologous end joining
r	0006397	biological_process	mRNA processing
r	0006974	biological_process	DNA damage response
r	0008104	biological_process	protein localization
r	0008380	biological_process	RNA splicing
r	0008610	biological_process	lipid biosynthetic process
r	0010498	biological_process	proteasomal protein catabolic process
r	0016020	cellular_component	membrane
r	0016567	biological_process	protein ubiquitination
r	0016607	cellular_component	nuclear speck
r	0016740	molecular_function	transferase activity
r	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
r	0035861	cellular_component	site of double-strand break
r	0042802	molecular_function	identical protein binding
r	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
r	0061630	molecular_function	ubiquitin protein ligase activity
r	0070534	biological_process	protein K63-linked ubiquitination
r	0071006	cellular_component	U2-type catalytic step 1 spliceosome
r	0071007	cellular_component	U2-type catalytic step 2 spliceosome
r	0071013	cellular_component	catalytic step 2 spliceosome
s	0000077	biological_process	DNA damage checkpoint signaling
s	0000209	biological_process	protein polyubiquitination
s	0000244	biological_process	spliceosomal tri-snRNP complex assembly
s	0000245	biological_process	spliceosomal complex assembly
s	0000398	biological_process	mRNA splicing, via spliceosome
s	0000974	cellular_component	Prp19 complex
s	0004842	molecular_function	ubiquitin-protein transferase activity
s	0005515	molecular_function	protein binding
s	0005634	cellular_component	nucleus
s	0005654	cellular_component	nucleoplasm
s	0005662	cellular_component	DNA replication factor A complex
s	0005681	cellular_component	spliceosomal complex
s	0005737	cellular_component	cytoplasm
s	0005811	cellular_component	lipid droplet
s	0005819	cellular_component	spindle
s	0005856	cellular_component	cytoskeleton
s	0006281	biological_process	DNA repair
s	0006303	biological_process	double-strand break repair via nonhomologous end joining
s	0006397	biological_process	mRNA processing
s	0006974	biological_process	DNA damage response
s	0008104	biological_process	protein localization
s	0008380	biological_process	RNA splicing
s	0008610	biological_process	lipid biosynthetic process
s	0010498	biological_process	proteasomal protein catabolic process
s	0016020	cellular_component	membrane
s	0016567	biological_process	protein ubiquitination
s	0016607	cellular_component	nuclear speck
s	0016740	molecular_function	transferase activity
s	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
s	0035861	cellular_component	site of double-strand break
s	0042802	molecular_function	identical protein binding
s	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
s	0061630	molecular_function	ubiquitin protein ligase activity
s	0070534	biological_process	protein K63-linked ubiquitination
s	0071006	cellular_component	U2-type catalytic step 1 spliceosome
s	0071007	cellular_component	U2-type catalytic step 2 spliceosome
s	0071013	cellular_component	catalytic step 2 spliceosome
t	0000077	biological_process	DNA damage checkpoint signaling
t	0000209	biological_process	protein polyubiquitination
t	0000244	biological_process	spliceosomal tri-snRNP complex assembly
t	0000245	biological_process	spliceosomal complex assembly
t	0000398	biological_process	mRNA splicing, via spliceosome
t	0000974	cellular_component	Prp19 complex
t	0004842	molecular_function	ubiquitin-protein transferase activity
t	0005515	molecular_function	protein binding
t	0005634	cellular_component	nucleus
t	0005654	cellular_component	nucleoplasm
t	0005662	cellular_component	DNA replication factor A complex
t	0005681	cellular_component	spliceosomal complex
t	0005737	cellular_component	cytoplasm
t	0005811	cellular_component	lipid droplet
t	0005819	cellular_component	spindle
t	0005856	cellular_component	cytoskeleton
t	0006281	biological_process	DNA repair
t	0006303	biological_process	double-strand break repair via nonhomologous end joining
t	0006397	biological_process	mRNA processing
t	0006974	biological_process	DNA damage response
t	0008104	biological_process	protein localization
t	0008380	biological_process	RNA splicing
t	0008610	biological_process	lipid biosynthetic process
t	0010498	biological_process	proteasomal protein catabolic process
t	0016020	cellular_component	membrane
t	0016567	biological_process	protein ubiquitination
t	0016607	cellular_component	nuclear speck
t	0016740	molecular_function	transferase activity
t	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
t	0035861	cellular_component	site of double-strand break
t	0042802	molecular_function	identical protein binding
t	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
t	0061630	molecular_function	ubiquitin protein ligase activity
t	0070534	biological_process	protein K63-linked ubiquitination
t	0071006	cellular_component	U2-type catalytic step 1 spliceosome
t	0071007	cellular_component	U2-type catalytic step 2 spliceosome
t	0071013	cellular_component	catalytic step 2 spliceosome
y	0000398	biological_process	mRNA splicing, via spliceosome
y	0000413	biological_process	protein peptidyl-prolyl isomerization
y	0003676	molecular_function	nucleic acid binding
y	0003723	molecular_function	RNA binding
y	0003729	molecular_function	mRNA binding
y	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
y	0005515	molecular_function	protein binding
y	0005576	cellular_component	extracellular region
y	0005634	cellular_component	nucleus
y	0005654	cellular_component	nucleoplasm
y	0005681	cellular_component	spliceosomal complex
y	0005737	cellular_component	cytoplasm
y	0005829	cellular_component	cytosol
y	0005886	cellular_component	plasma membrane
y	0006355	biological_process	regulation of DNA-templated transcription
y	0006397	biological_process	mRNA processing
y	0006457	biological_process	protein folding
y	0008143	molecular_function	poly(A) binding
y	0008380	biological_process	RNA splicing
y	0016018	molecular_function	cyclosporin A binding
y	0016607	cellular_component	nuclear speck
y	0016853	molecular_function	isomerase activity
y	0034774	cellular_component	secretory granule lumen
y	0043231	cellular_component	intracellular membrane-bounded organelle
y	0045070	biological_process	positive regulation of viral genome replication
y	0071007	cellular_component	U2-type catalytic step 2 spliceosome
y	0071013	cellular_component	catalytic step 2 spliceosome
y	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue IHP A 3000

Chain	Residue
A	ARG163
A	LYS442
A	HIS584
A	LYS609
A	HIS610
A	TYR613
A	ASN617
A	LYS623
A	GLY624

---

site_id	AC2
Number of Residues	19
Details	binding site for residue GTP C 1500

Chain	Residue
C	LEU138
C	HIS139
C	HIS140
C	GLY141
C	LYS142
C	THR143
C	CYS144
C	GLN163
C	LEU165
C	GLY178
C	GLY180
C	GLY207
C	LYS259
C	ASP261
C	ARG262
C	SER311
C	SER312
C	GLN313
C	MG1501

---

site_id	AC3
Number of Residues	2
Details	binding site for residue MG C 1501

Chain	Residue
C	THR143
C	GTP1500

---

site_id	AC4
Number of Residues	3
Details	binding site for residue MG F 200

Chain	Residue
F	G54
F	G72
F	U74

---

site_id	AC5
Number of Residues	3
Details	binding site for residue MG F 201

Chain	Residue
F	A53
F	G54
F	U74

---

site_id	AC6
Number of Residues	1
Details	binding site for residue MG F 202

Chain	Residue
F	G75

---

site_id	AC7
Number of Residues	2
Details	binding site for residue MG F 203

Chain	Residue
F	G71
F	G75

---

site_id	AC8
Number of Residues	4
Details	binding site for residue MG F 204

Chain	Residue
A	GLN675
F	G54
F	C55
F	G71

---

site_id	AC9
Number of Residues	2
Details	binding site for residue MG F 205

Chain	Residue
F	A47
F	A48

---

site_id	AD1
Number of Residues	4
Details	binding site for residue ZN N 201

Chain	Residue
N	CYS105
N	CYS117
N	CYS119
N	CYS134

---

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN N 202

Chain	Residue
N	CYS101
N	CYS102
N	CYS105
N	CYS137

---

site_id	AD3
Number of Residues	4
Details	binding site for residue ZN N 203

Chain	Residue
N	CYS101
N	CYS119
N	CYS139
N	CYS142

---

site_id	AD4
Number of Residues	4
Details	binding site for residue ZN O 501

Chain	Residue
O	CYS24
O	CYS27
O	CYS81
O	CYS84

---

site_id	AD5
Number of Residues	4
Details	binding site for residue ZN O 502

Chain	Residue
O	CYS45
O	CYS48
O	CYS71
O	CYS74

---

site_id	AD6
Number of Residues	4
Details	binding site for residue ZN O 503

Chain	Residue
O	CYS165
O	CYS173
O	CYS179
O	HIS183

---

site_id	AD7
Number of Residues	5
Details	binding site for residue ZN U 900

Chain	Residue
U	CYS675
U	TYR677
U	CYS678
U	HIS718
U	HIS765

---

Functional Information from PROSITE/UniProt

site_id	PS00997
Number of Residues	23
Details	G10_1 G10 protein signature 1. LCClRCiqtrDtNfgtnCiCRVP

Chain	Residue	Details
N	LEU100-PRO122

---

site_id	PS00998
Number of Residues	10
Details	G10_2 G10 protein signature 2. CtHCGCRGCS

Chain	Residue	Details
N	CYS134-SER143

---

site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. GvIILDEAHE

Chain	Residue	Details
V	GLY255-GLU264

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LASAgfDrLILLWNV

Chain	Residue	Details
E	LEU81-VAL95
E	LEU124-SER138
E	VAL167-ILE181
E	ILE208-LEU222
E	ILE300-THR314
T	LEU303-VAL317
T	ILE345-LEU359
W	LEU304-VAL318
r	LEU407-LEU421

---

site_id	PS00170
Number of Residues	18
Details	CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. FkgSsFHRIIpqFMcQGG

Chain	Residue	Details
y	PHE184-GLY201
S	TYR48-GLY65

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Omega-N-methylarginine; alternate => ECO:0007744|PubMed:24129315

Chain	Residue	Details
b	ARG108
b	ARG112
i	ARG108
i	ARG112
S	THR119
S	LYS125

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Omega-N-methylarginine => ECO:0000269|Ref.10

Chain	Residue	Details
b	ARG147
i	ARG147
r	LYS122
r	LYS261
s	LYS122
s	LYS261
t	LYS122
t	LYS261

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:P63162

Chain	Residue	Details
b	ARG172
i	ARG172
r	LYS179
r	LYS244
s	LYS179
s	LYS244
t	LYS179
t	LYS244

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
V	LYS786
o	SER255
d	LYS8
k	LYS6
k	LYS8

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733

Chain	Residue	Details
o	LYS172
U	LYS604

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
R	LYS23
R	LYS416
R	LYS441
R	LYS452
o	LYS221
R	LYS122
R	LYS141
R	LYS158
R	LYS258
R	LYS286
R	LYS339
R	LYS344

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733

Chain	Residue	Details
L	THR385
R	LYS509

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:28112733

Chain	Residue	Details
R	LYS81

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25772364

Chain	Residue	Details
R	LYS97
L	THR411

---

site_id	SWS_FT_FI10
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733

Chain	Residue	Details
R	LYS170
R	LYS193
R	LYS240

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:18583928, ECO:0007744|PubMed:23186163

Chain	Residue	Details
L	SER417

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:18583928, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
L	THR424
L	THR438

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163

Chain	Residue	Details
L	THR430

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
L	SER437

---

site_id	SWS_FT_FI15
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
L	LYS135
L	LYS487

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733

Chain	Residue	Details
L	LYS219

---