6ICT
Structure of SETD3 bound to SAH and methylated actin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0018064 | molecular_function | protein-L-histidine N-tele-methyltransferase activity |
| A | 0030047 | biological_process | actin modification |
| B | 0018064 | molecular_function | protein-L-histidine N-tele-methyltransferase activity |
| B | 0030047 | biological_process | actin modification |
| C | 0018064 | molecular_function | protein-L-histidine N-tele-methyltransferase activity |
| C | 0030047 | biological_process | actin modification |
| D | 0018064 | molecular_function | protein-L-histidine N-tele-methyltransferase activity |
| D | 0030047 | biological_process | actin modification |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue SAH A 1000 |
| Chain | Residue |
| A | ARG75 |
| A | ASN278 |
| A | HIS279 |
| A | TYR313 |
| A | SER325 |
| A | PHE327 |
| A | HOH1182 |
| A | HOH1195 |
| A | HOH1201 |
| A | HOH1276 |
| E | HIC73 |
| A | GLU104 |
| A | PHE106 |
| A | PRO180 |
| A | THR253 |
| A | ARG254 |
| A | ASP275 |
| A | MET276 |
| A | CYS277 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | binding site for residue SAH B 1001 |
| Chain | Residue |
| B | ARG75 |
| B | GLU104 |
| B | PHE106 |
| B | PRO180 |
| B | ARG254 |
| B | ASP275 |
| B | MET276 |
| B | CYS277 |
| B | ASN278 |
| B | HIS279 |
| B | TYR313 |
| B | SER325 |
| B | PHE327 |
| B | HOH1126 |
| B | HOH1238 |
| B | HOH1242 |
| B | HOH1250 |
| B | HOH1282 |
| G | HIC73 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | binding site for residue SAH C 601 |
| Chain | Residue |
| C | ARG75 |
| C | GLU104 |
| C | PHE106 |
| C | THR253 |
| C | ARG254 |
| C | ASP275 |
| C | MET276 |
| C | ASN278 |
| C | HIS279 |
| C | TYR313 |
| C | SER325 |
| C | PHE327 |
| C | HOH716 |
| C | HOH863 |
| C | HOH864 |
| C | HOH870 |
| C | HOH883 |
| H | HIC73 |
| site_id | AC4 |
| Number of Residues | 21 |
| Details | binding site for residue SAH D 601 |
| Chain | Residue |
| D | ARG75 |
| D | GLU104 |
| D | PHE106 |
| D | PRO180 |
| D | THR253 |
| D | ARG254 |
| D | ASP275 |
| D | MET276 |
| D | CYS277 |
| D | ASN278 |
| D | HIS279 |
| D | TYR313 |
| D | SER325 |
| D | PHE327 |
| D | HOH796 |
| D | HOH814 |
| D | HOH846 |
| D | HOH848 |
| D | HOH862 |
| D | HOH889 |
| I | HIC73 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 880 |
| Details | Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30626964","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30785395","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31388018","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31911441","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31993215","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32503840","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2011","submissionDatabase":"PDB data bank","title":"Crystal structure of human SET domain-containing protein 3.","authors":["Zeng H.","Dong A.","Walker J.R.","Loppnau P.","Bountra C.","Weigelt J.","Arrowsmith C.H.","Edwards A.M.","Min J.","Wu H."]}},{"source":"PDB","id":"3SMT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ICT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ICV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6JAT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MBK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6MBL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OX5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6V62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6V63","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WK1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WK2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"PubMed","id":"30526847","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30626964","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30785395","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31388018","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32503840","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
