6ICG
Grb2 SH2 domain in phosphopeptide free form
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 201 |
| Chain | Residue |
| A | ARG67 |
| A | ARG86 |
| A | SER88 |
| A | GLU89 |
| A | SER90 |
| A | HOH319 |
| A | HOH322 |
| A | HOH336 |
| B | LYS109 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 202 |
| Chain | Residue |
| A | TRP60 |
| A | ASN129 |
| A | ARG136 |
| A | HOH301 |
| A | HOH302 |
| A | HOH461 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 203 |
| Chain | Residue |
| A | GLU71 |
| A | VAL105 |
| A | HOH305 |
| A | HOH325 |
| A | HOH360 |
| A | HOH361 |
| A | HOH368 |
| B | TRP121 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 B 201 |
| Chain | Residue |
| A | LYS109 |
| A | LEU111 |
| B | ARG67 |
| B | ARG86 |
| B | SER88 |
| B | GLU89 |
| B | SER90 |
| B | HOH358 |
| B | HOH404 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 202 |
| Chain | Residue |
| B | HIS79 |
| B | ASP80 |
| B | HOH312 |
| B | HOH324 |
| B | HOH347 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 203 |
| Chain | Residue |
| B | LYS76 |
| B | LYS124 |
| B | HOH343 |
| B | HOH450 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 184 |
| Details | Domain: {"description":"SH2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"34348893","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
