6IBO
Catalytic deficiency of O-GlcNAc transferase leads to X-linked intellectual disability
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 27 |
| Details | binding site for residue 12V A 1101 |
| Chain | Residue |
| A | HIS508 |
| A | LYS852 |
| A | VAL905 |
| A | ALA906 |
| A | LYS908 |
| A | HIS911 |
| A | ARG914 |
| A | CYS927 |
| A | HIS930 |
| A | THR931 |
| A | THR932 |
| A | PRO569 |
| A | ASP935 |
| A | HOH1268 |
| A | HOH1274 |
| A | HOH1310 |
| C | ALA3 |
| C | VAL4 |
| C | SER5 |
| C | HOH101 |
| A | THR570 |
| A | LEU663 |
| A | GLY664 |
| A | PRO666 |
| A | PHE704 |
| A | GLN849 |
| A | TYR851 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 A 1102 |
| Chain | Residue |
| A | GLN423 |
| A | PRO446 |
| A | VAL476 |
| A | VAL881 |
| A | ASN885 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 A 1103 |
| Chain | Residue |
| A | SER805 |
| A | THR810 |
| A | ILE813 |
| A | PRO824 |
| A | THR826 |
| A | ILE828 |
| A | HOH1362 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 10"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 11"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 12"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | Repeat: {"description":"TPR 13; truncated"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 19 |
| Details | Region: {"description":"Required for phosphatidylinositol 3,4,5-triphosphate binding","evidences":[{"source":"UniProtKB","id":"P56558","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Motif: {"description":"DFP motif","evidences":[{"source":"PubMed","id":"27713473","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 16 |
| Details | Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"21240259","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26678539","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23103939","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4GYW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by AMPK","evidences":[{"source":"PubMed","id":"24563466","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37541260","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P56558","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"O-linked (GlcNAc) serine; by autocatalysis","evidences":[{"source":"PubMed","id":"27713473","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
