6I7J
Crystal structure of monomeric FICD mutant L258D
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 501 |
| Chain | Residue |
| A | ARG217 |
| A | HIS363 |
| A | GLY368 |
| A | ASN369 |
| A | GLY370 |
| A | SO4506 |
| A | HOH612 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 502 |
| Chain | Residue |
| A | TYR400 |
| A | HOH622 |
| A | THR239 |
| A | SER241 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 503 |
| Chain | Residue |
| A | GLN112 |
| A | ARG295 |
| A | GLY299 |
| A | TYR300 |
| A | HOH611 |
| A | HOH619 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 504 |
| Chain | Residue |
| A | LYS203 |
| A | TYR386 |
| A | HOH607 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 505 |
| Chain | Residue |
| A | SER241 |
| A | HIS245 |
| A | SER397 |
| A | TYR400 |
| A | HIS401 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 506 |
| Chain | Residue |
| A | GLY370 |
| A | TYR399 |
| A | SO4501 |
| A | PG4513 |
| A | HOH620 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 507 |
| Chain | Residue |
| A | ARG396 |
| A | TYR400 |
| A | PG4513 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue 1PE A 508 |
| Chain | Residue |
| A | TRP337 |
| A | TYR357 |
| A | LYS358 |
| A | PG4512 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue 1PE A 509 |
| Chain | Residue |
| A | MET219 |
| A | TYR224 |
| A | HOH633 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue 1PE A 510 |
| Chain | Residue |
| A | ILE320 |
| A | ARG392 |
| A | ASP427 |
| A | PEG515 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue PG4 A 511 |
| Chain | Residue |
| A | TYR161 |
| A | HOH642 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue PG4 A 512 |
| Chain | Residue |
| A | TYR357 |
| A | LYS358 |
| A | TYR361 |
| A | ALA406 |
| A | GLY409 |
| A | 1PE508 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue PG4 A 513 |
| Chain | Residue |
| A | HIS319 |
| A | TYR361 |
| A | TYR400 |
| A | GLU404 |
| A | ASN407 |
| A | SO4506 |
| A | SO4507 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 514 |
| Chain | Residue |
| A | ALA109 |
| A | GLN112 |
| A | MET135 |
| A | TYR300 |
| site_id | AD6 |
| Number of Residues | 1 |
| Details | binding site for residue PEG A 515 |
| Chain | Residue |
| A | 1PE510 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue PG4 A 516 |
| Chain | Residue |
| A | VAL205 |
| A | MET206 |
| A | ILE208 |
| A | LEU215 |
| A | MET219 |
| A | TYR386 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue PG4 A 517 |
| Chain | Residue |
| A | GLY120 |
| A | LYS121 |
| A | ARG122 |
| A | GLU123 |
| A | LYS124 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 33 |
| Details | Repeat: {"description":"TPR 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 135 |
| Details | Domain: {"description":"Fido","evidences":[{"source":"PROSITE-ProRule","id":"PRU00791","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | Motif: {"description":"Inhibitory (S/T)XXXE(G/N) motif","evidences":[{"source":"PubMed","id":"22266942","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"22266942","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25435325","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U07","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U0U","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25435325","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U07","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U0S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4U0U","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25435325","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4U07","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Site: {"description":"Important for autoinhibition of adenylyltransferase activity","evidences":[{"source":"PubMed","id":"22266942","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25435325","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"O-AMP-threonine; by autocatalysis","evidences":[{"source":"PubMed","id":"25601083","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25601083","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
