6I7J

Crystal structure of monomeric FICD mutant L258D

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue SO4 A 501

Chain	Residue
A	ARG217
A	HIS363
A	GLY368
A	ASN369
A	GLY370
A	SO4506
A	HOH612

---

site_id	AC2
Number of Residues	4
Details	binding site for residue SO4 A 502

Chain	Residue
A	TYR400
A	HOH622
A	THR239
A	SER241

---

site_id	AC3
Number of Residues	6
Details	binding site for residue SO4 A 503

Chain	Residue
A	GLN112
A	ARG295
A	GLY299
A	TYR300
A	HOH611
A	HOH619

---

site_id	AC4
Number of Residues	3
Details	binding site for residue SO4 A 504

Chain	Residue
A	LYS203
A	TYR386
A	HOH607

---

site_id	AC5
Number of Residues	5
Details	binding site for residue SO4 A 505

Chain	Residue
A	SER241
A	HIS245
A	SER397
A	TYR400
A	HIS401

---

site_id	AC6
Number of Residues	5
Details	binding site for residue SO4 A 506

Chain	Residue
A	GLY370
A	TYR399
A	SO4501
A	PG4513
A	HOH620

---

site_id	AC7
Number of Residues	3
Details	binding site for residue SO4 A 507

Chain	Residue
A	ARG396
A	TYR400
A	PG4513

---

site_id	AC8
Number of Residues	4
Details	binding site for residue 1PE A 508

Chain	Residue
A	TRP337
A	TYR357
A	LYS358
A	PG4512

---

site_id	AC9
Number of Residues	3
Details	binding site for residue 1PE A 509

Chain	Residue
A	MET219
A	TYR224
A	HOH633

---

site_id	AD1
Number of Residues	4
Details	binding site for residue 1PE A 510

Chain	Residue
A	ILE320
A	ARG392
A	ASP427
A	PEG515

---

site_id	AD2
Number of Residues	2
Details	binding site for residue PG4 A 511

Chain	Residue
A	TYR161
A	HOH642

---

site_id	AD3
Number of Residues	6
Details	binding site for residue PG4 A 512

Chain	Residue
A	TYR357
A	LYS358
A	TYR361
A	ALA406
A	GLY409
A	1PE508

---

site_id	AD4
Number of Residues	7
Details	binding site for residue PG4 A 513

Chain	Residue
A	HIS319
A	TYR361
A	TYR400
A	GLU404
A	ASN407
A	SO4506
A	SO4507

---

site_id	AD5
Number of Residues	4
Details	binding site for residue PEG A 514

Chain	Residue
A	ALA109
A	GLN112
A	MET135
A	TYR300

---

site_id	AD6
Number of Residues	1
Details	binding site for residue PEG A 515

Chain	Residue
A	1PE510

---

site_id	AD7
Number of Residues	6
Details	binding site for residue PG4 A 516

Chain	Residue
A	VAL205
A	MET206
A	ILE208
A	LEU215
A	MET219
A	TYR386

---

site_id	AD8
Number of Residues	5
Details	binding site for residue PG4 A 517

Chain	Residue
A	GLY120
A	LYS121
A	ARG122
A	GLU123
A	LYS124

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000269|PubMed:22266942

Chain	Residue	Details
A	HIS363

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:25435325, ECO:0007744|PDB:4U07, ECO:0007744|PDB:4U0U

Chain	Residue	Details
A	GLU234

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:25435325, ECO:0007744|PDB:4U07, ECO:0007744|PDB:4U0S, ECO:0007744|PDB:4U0U

Chain	Residue	Details
A	VAL316
A	TYR399
A	ASN407

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:25435325, ECO:0007744|PDB:4U07

Chain	Residue	Details
A	ASP367

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Important for autoinhibition of adenylyltransferase activity => ECO:0000269|PubMed:22266942, ECO:0000269|PubMed:25435325

Chain	Residue	Details
A	GLU234

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: O-AMP-threonine; by autocatalysis => ECO:0000305|PubMed:25601083

Chain	Residue	Details
A	THR183

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498, ECO:0000269|PubMed:25601083

Chain	Residue	Details
A	ASN275

---