6I6L
Papaver somniferum O-methyltransferase 1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008171 | molecular_function | O-methyltransferase activity |
| A | 0009708 | biological_process | benzyl isoquinoline alkaloid biosynthetic process |
| A | 0009820 | biological_process | alkaloid metabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030762 | molecular_function | tetrahydrocolumbamine 2-O-methyltransferase activity |
| A | 0030777 | molecular_function | (S)-scoulerine 9-O-methyltransferase activity |
| A | 0032259 | biological_process | methylation |
| A | 0046983 | molecular_function | protein dimerization activity |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0008171 | molecular_function | O-methyltransferase activity |
| B | 0009708 | biological_process | benzyl isoquinoline alkaloid biosynthetic process |
| B | 0009820 | biological_process | alkaloid metabolic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030762 | molecular_function | tetrahydrocolumbamine 2-O-methyltransferase activity |
| B | 0030777 | molecular_function | (S)-scoulerine 9-O-methyltransferase activity |
| B | 0032259 | biological_process | methylation |
| B | 0046983 | molecular_function | protein dimerization activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue H68 A 401 |
| Chain | Residue |
| A | GLU153 |
| A | HOH525 |
| A | HOH561 |
| A | PHE156 |
| A | THR157 |
| A | TRP293 |
| A | HIS296 |
| A | ASP297 |
| A | ASN339 |
| A | ILE342 |
| A | SAH402 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | binding site for residue SAH A 402 |
| Chain | Residue |
| A | PHE190 |
| A | MET207 |
| A | SER211 |
| A | GLY235 |
| A | GLY237 |
| A | ASP258 |
| A | LEU259 |
| A | VAL262 |
| A | ASP278 |
| A | MET279 |
| A | PHE280 |
| A | LYS292 |
| A | TRP293 |
| A | ASP297 |
| A | H68401 |
| A | HOH513 |
| A | HOH544 |
| A | HOH554 |
| A | HOH573 |
| A | HOH651 |
| A | HOH658 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue H68 B 401 |
| Chain | Residue |
| B | GLU153 |
| B | PHE190 |
| B | TRP293 |
| B | HIS296 |
| B | ASP297 |
| B | ASN339 |
| B | ILE342 |
| B | LEU347 |
| B | SAH402 |
| B | HOH531 |
| B | HOH557 |
| site_id | AC4 |
| Number of Residues | 22 |
| Details | binding site for residue SAH B 402 |
| Chain | Residue |
| B | PHE190 |
| B | MET207 |
| B | SER211 |
| B | GLY235 |
| B | GLY237 |
| B | ASP258 |
| B | LEU259 |
| B | VAL262 |
| B | ASP278 |
| B | MET279 |
| B | PHE280 |
| B | LYS292 |
| B | TRP293 |
| B | ASP297 |
| B | H68401 |
| B | HOH515 |
| B | HOH520 |
| B | HOH564 |
| B | HOH572 |
| B | HOH624 |
| B | HOH633 |
| B | HOH638 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01020","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2019","firstPage":"3840","lastPage":"3848","volume":"9","journal":"ACS Catal.","title":"Structure of Papaver somniferum O-methyltransferase 1 reveals initiation of noscapine biosynthesis with implications for plant natural product methylation.","authors":["Cabry M.P.","Offen W.A.","Saleh P.","Li Y.","Winzer T.","Graham I.A.","Davies G.J."],"citationCrossReferences":[{"database":"DOI","id":"10.1021/acscatal.9b01038"}]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"6I6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I6N","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q5C9L7","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2019","firstPage":"3840","lastPage":"3848","volume":"9","journal":"ACS Catal.","title":"Structure of Papaver somniferum O-methyltransferase 1 reveals initiation of noscapine biosynthesis with implications for plant natural product methylation.","authors":["Cabry M.P.","Offen W.A.","Saleh P.","Li Y.","Winzer T.","Graham I.A.","Davies G.J."],"citationCrossReferences":[{"database":"DOI","id":"10.1021/acscatal.9b01038"}]}},{"source":"PDB","id":"6I6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I6N","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01020","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2019","firstPage":"3840","lastPage":"3848","volume":"9","journal":"ACS Catal.","title":"Structure of Papaver somniferum O-methyltransferase 1 reveals initiation of noscapine biosynthesis with implications for plant natural product methylation.","authors":["Cabry M.P.","Offen W.A.","Saleh P.","Li Y.","Winzer T.","Graham I.A.","Davies G.J."],"citationCrossReferences":[{"database":"DOI","id":"10.1021/acscatal.9b01038"}]}},{"source":"PDB","id":"6I6K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I6N","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
