6I6J
Crystal structure of the KDEL receptor bound to synthetic nanobody.
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000139 | cellular_component | Golgi membrane |
A | 0005046 | molecular_function | KDEL sequence binding |
A | 0005783 | cellular_component | endoplasmic reticulum |
A | 0005789 | cellular_component | endoplasmic reticulum membrane |
A | 0005794 | cellular_component | Golgi apparatus |
A | 0005801 | cellular_component | cis-Golgi network |
A | 0006621 | biological_process | protein retention in ER lumen |
A | 0006888 | biological_process | endoplasmic reticulum to Golgi vesicle-mediated transport |
A | 0006890 | biological_process | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
A | 0015031 | biological_process | protein transport |
A | 0016020 | cellular_component | membrane |
A | 0016192 | biological_process | vesicle-mediated transport |
A | 0030663 | cellular_component | COPI-coated vesicle membrane |
A | 0031410 | cellular_component | cytoplasmic vesicle |
A | 0035437 | biological_process | maintenance of protein localization in endoplasmic reticulum |
A | 0046923 | molecular_function | ER retention sequence binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 8 |
Details | binding site for residue OLC A 401 |
Chain | Residue |
A | PHE97 |
A | VAL109 |
A | ASN110 |
A | TYR125 |
A | SER128 |
A | VAL129 |
A | PHE153 |
A | ALA183 |
site_id | AC2 |
Number of Residues | 7 |
Details | binding site for residue OLC C 201 |
Chain | Residue |
C | GLY27 |
C | PRO29 |
C | TRP33 |
C | ASN75 |
C | ASN78 |
C | THR79 |
C | ALA25 |
Functional Information from PROSITE/UniProt
site_id | PS00951 |
Number of Residues | 18 |
Details | ER_LUMEN_RECEPTOR_1 ER lumen protein retaining receptor signature 1. GISgKsQlLFaLVFttRY |
Chain | Residue | Details |
A | GLY31-TYR48 |
site_id | PS00952 |
Number of Residues | 10 |
Details | ER_LUMEN_RECEPTOR_2 ER lumen protein retaining receptor signature 2. LESVAILPQL |
Chain | Residue | Details |
A | LEU126-LEU135 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 22 |
Details | TOPO_DOM: Lumenal => ECO:0000269|PubMed:30846601 |
Chain | Residue | Details |
A | MET1-PHE4 | |
A | THR53-LEU58 | |
A | HIS111-LEU116 | |
A | ARG169-LEU178 |
site_id | SWS_FT_FI2 |
Number of Residues | 131 |
Details | TRANSMEM: Helical => ECO:0000269|PubMed:30846601 |
Chain | Residue | Details |
A | ARG5-TRP24 | |
A | SER33-PHE52 | |
A | TYR59-TYR79 | |
A | PHE93-ASN110 | |
A | GLU117-LEU135 | |
A | HIS150-TRP168 | |
A | ILE179-VAL199 |
site_id | SWS_FT_FI3 |
Number of Residues | 32 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:30846601 |
Chain | Residue | Details |
A | LYS25-ILE32 | |
A | MET80-THR92 | |
A | PHE136-THR149 |
site_id | SWS_FT_FI4 |
Number of Residues | 3 |
Details | SITE: Interaction with the K-D-E-L motif on target proteins => ECO:0000269|PubMed:30846601 |
Chain | Residue | Details |
A | ARG5 | |
A | SER54 | |
A | GLU117 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | SITE: Important for recycling of cargo proteins with the sequence motif K-D-E-L from the Golgi to the endoplasmic reticulum => ECO:0000250|UniProtKB:P24390 |
Chain | Residue | Details |
A | ASP193 |