6I5M

Gamma subunit of the translation initiation factor 2 from Sulfolobus solfataricus in complex with GDP and formate ion

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0000166	molecular_function	nucleotide binding
A	0001731	biological_process	formation of translation preinitiation complex
A	0003743	molecular_function	translation initiation factor activity
A	0003746	molecular_function	translation elongation factor activity
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0006412	biological_process	translation
A	0006413	biological_process	translational initiation
A	0006414	biological_process	translational elongation
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	28
Details	binding site for residue GDP A 501

Chain	Residue
A	ASP19
A	ASP152
A	ASP152
A	VAL153
A	LYS156
A	SER184
A	ALA185
A	LEU186
A	FMT507
A	MG519
A	NA521
A	HIS20
A	HOH610
A	HOH616
A	HOH619
A	HOH621
A	HOH689
A	HOH764
A	HOH774
A	HOH855
A	HOH865
A	GLY21
A	LYS22
A	THR23
A	THR24
A	ASN149
A	LYS150
A	VAL151

---

site_id	AC2
Number of Residues	6
Details	binding site for residue FMT A 502

Chain	Residue
A	MET45
A	THR46
A	GLY96
A	HIS97
A	HOH610
A	HOH616

---

site_id	AC3
Number of Residues	7
Details	binding site for residue FMT A 503

Chain	Residue
A	SER314
A	VAL361
A	SER364
A	VAL386
A	ALA387
A	HOH618
A	HOH637

---

site_id	AC4
Number of Residues	5
Details	binding site for residue FMT A 504

Chain	Residue
A	VAL217
A	GLY313
A	SER363
A	HOH601
A	HOH631

---

site_id	AC5
Number of Residues	3
Details	binding site for residue FMT A 505

Chain	Residue
A	LEU336
A	GLU337
A	ARG338

---

site_id	AC6
Number of Residues	6
Details	binding site for residue FMT A 506

Chain	Residue
A	ARG219
A	SER220
A	THR306
A	LYS307
A	HOH630
A	HOH675

---

site_id	AC7
Number of Residues	5
Details	binding site for residue FMT A 507

Chain	Residue
A	ASN121
A	LYS150
A	ASP152
A	GDP501
A	HOH705

---

site_id	AC8
Number of Residues	1
Details	binding site for residue FMT A 508

Chain	Residue
A	HIS187

---

site_id	AC9
Number of Residues	6
Details	binding site for residue FMT A 509

Chain	Residue
A	TYR333
A	LEU335
A	PRO350
A	ILE351
A	HOH676
A	HOH809

---

site_id	AD1
Number of Residues	3
Details	binding site for residue FMT A 510

Chain	Residue
A	LEU367
A	ARG383
A	ARG384

---

site_id	AD2
Number of Residues	5
Details	binding site for residue FMT A 511

Chain	Residue
A	GLU344
A	ALA402
A	HOH684
A	HOH755
A	HOH967

---

site_id	AD3
Number of Residues	2
Details	binding site for residue FMT A 512

Chain	Residue
A	HOH762
A	HOH835

---

site_id	AD4
Number of Residues	2
Details	binding site for residue FMT A 513

Chain	Residue
A	GLU158
A	HOH837

---

site_id	AD5
Number of Residues	4
Details	binding site for residue FMT A 514

Chain	Residue
A	ALA342
A	LYS343
A	GLU344
A	HOH625

---

site_id	AD6
Number of Residues	4
Details	binding site for residue FMT A 515

Chain	Residue
A	LYS42
A	TYR163
A	PRO179
A	ILE180

---

site_id	AD7
Number of Residues	5
Details	binding site for residue FMT A 516

Chain	Residue
A	LYS347
A	VAL348
A	ASP349
A	ARG399
A	HOH684

---

site_id	AD8
Number of Residues	6
Details	binding site for residue FMT A 517

Chain	Residue
A	LYS36
A	HIS37
A	SER38
A	ASN190
A	SER193
A	HOH693

---

site_id	AD9
Number of Residues	6
Details	binding site for residue MG A 519

Chain	Residue
A	GDP501
A	HOH610
A	HOH619
A	HOH621
A	HOH812
A	THR23

---

site_id	AE1
Number of Residues	6
Details	binding site for residue MG A 520

Chain	Residue
A	HIS187
A	HIS187
A	HIS187
A	HOH896
A	HOH896
A	HOH896

---

site_id	AE2
Number of Residues	6
Details	binding site for residue NA A 521

Chain	Residue
A	VAL151
A	VAL154
A	GDP501
A	HOH645
A	HOH855
A	HOH919

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	199
Details	Domain: {"description":"tr-type G","evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	Region: {"description":"G1","evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Region: {"description":"G2","evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Region: {"description":"G3","evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Region: {"description":"G4","evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Region: {"description":"G5","evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25690901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4RCY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RD1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25690901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4RD1","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16407071","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25690901","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2AHO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8U082","evidenceCode":"ECO:0000250"},{"source":"HAMAP-Rule","id":"MF_00119","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---