6I4Z

Crystal structure of the disease-causing P453L mutant of the human dihydrolipoamide dehydrogenase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001669	cellular_component	acrosomal vesicle
A	0004148	molecular_function	dihydrolipoyl dehydrogenase (NADH) activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005929	cellular_component	cilium
A	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
A	0006099	biological_process	tricarboxylic acid cycle
A	0006103	biological_process	2-oxoglutarate metabolic process
A	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
A	0006508	biological_process	proteolysis
A	0007369	biological_process	gastrulation
A	0009083	biological_process	branched-chain amino acid catabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
A	0019474	biological_process	L-lysine catabolic process to acetyl-CoA
A	0031410	cellular_component	cytoplasmic vesicle
A	0031514	cellular_component	motile cilium
A	0042391	biological_process	regulation of membrane potential
A	0043159	cellular_component	acrosomal matrix
A	0045252	cellular_component	oxoglutarate dehydrogenase complex
A	0045254	cellular_component	pyruvate dehydrogenase complex
A	0048240	biological_process	sperm capacitation
A	0050660	molecular_function	flavin adenine dinucleotide binding
A	0120551	biological_process	2-oxoglutarate decarboxylation to succinyl-CoA
A	0120552	biological_process	branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA
A	0160157	cellular_component	branched-chain alpha-ketoacid dehydrogenase complex
A	0160167	cellular_component	oxoadipate dehydrogenase complex
B	0001669	cellular_component	acrosomal vesicle
B	0004148	molecular_function	dihydrolipoyl dehydrogenase (NADH) activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005929	cellular_component	cilium
B	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
B	0006099	biological_process	tricarboxylic acid cycle
B	0006103	biological_process	2-oxoglutarate metabolic process
B	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
B	0006508	biological_process	proteolysis
B	0007369	biological_process	gastrulation
B	0009083	biological_process	branched-chain amino acid catabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
B	0019474	biological_process	L-lysine catabolic process to acetyl-CoA
B	0031410	cellular_component	cytoplasmic vesicle
B	0031514	cellular_component	motile cilium
B	0042391	biological_process	regulation of membrane potential
B	0043159	cellular_component	acrosomal matrix
B	0045252	cellular_component	oxoglutarate dehydrogenase complex
B	0045254	cellular_component	pyruvate dehydrogenase complex
B	0048240	biological_process	sperm capacitation
B	0050660	molecular_function	flavin adenine dinucleotide binding
B	0120551	biological_process	2-oxoglutarate decarboxylation to succinyl-CoA
B	0120552	biological_process	branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA
B	0160157	cellular_component	branched-chain alpha-ketoacid dehydrogenase complex
B	0160167	cellular_component	oxoadipate dehydrogenase complex
C	0001669	cellular_component	acrosomal vesicle
C	0004148	molecular_function	dihydrolipoyl dehydrogenase (NADH) activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005929	cellular_component	cilium
C	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
C	0006099	biological_process	tricarboxylic acid cycle
C	0006103	biological_process	2-oxoglutarate metabolic process
C	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
C	0006508	biological_process	proteolysis
C	0007369	biological_process	gastrulation
C	0009083	biological_process	branched-chain amino acid catabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
C	0019474	biological_process	L-lysine catabolic process to acetyl-CoA
C	0031410	cellular_component	cytoplasmic vesicle
C	0031514	cellular_component	motile cilium
C	0042391	biological_process	regulation of membrane potential
C	0043159	cellular_component	acrosomal matrix
C	0045252	cellular_component	oxoglutarate dehydrogenase complex
C	0045254	cellular_component	pyruvate dehydrogenase complex
C	0048240	biological_process	sperm capacitation
C	0050660	molecular_function	flavin adenine dinucleotide binding
C	0120551	biological_process	2-oxoglutarate decarboxylation to succinyl-CoA
C	0120552	biological_process	branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA
C	0160157	cellular_component	branched-chain alpha-ketoacid dehydrogenase complex
C	0160167	cellular_component	oxoadipate dehydrogenase complex
D	0001669	cellular_component	acrosomal vesicle
D	0004148	molecular_function	dihydrolipoyl dehydrogenase (NADH) activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0005929	cellular_component	cilium
D	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
D	0006099	biological_process	tricarboxylic acid cycle
D	0006103	biological_process	2-oxoglutarate metabolic process
D	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
D	0006508	biological_process	proteolysis
D	0007369	biological_process	gastrulation
D	0009083	biological_process	branched-chain amino acid catabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
D	0019474	biological_process	L-lysine catabolic process to acetyl-CoA
D	0031410	cellular_component	cytoplasmic vesicle
D	0031514	cellular_component	motile cilium
D	0042391	biological_process	regulation of membrane potential
D	0043159	cellular_component	acrosomal matrix
D	0045252	cellular_component	oxoglutarate dehydrogenase complex
D	0045254	cellular_component	pyruvate dehydrogenase complex
D	0048240	biological_process	sperm capacitation
D	0050660	molecular_function	flavin adenine dinucleotide binding
D	0120551	biological_process	2-oxoglutarate decarboxylation to succinyl-CoA
D	0120552	biological_process	branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA
D	0160157	cellular_component	branched-chain alpha-ketoacid dehydrogenase complex
D	0160167	cellular_component	oxoadipate dehydrogenase complex
E	0001669	cellular_component	acrosomal vesicle
E	0004148	molecular_function	dihydrolipoyl dehydrogenase (NADH) activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0005929	cellular_component	cilium
E	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
E	0006099	biological_process	tricarboxylic acid cycle
E	0006103	biological_process	2-oxoglutarate metabolic process
E	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
E	0006508	biological_process	proteolysis
E	0007369	biological_process	gastrulation
E	0009083	biological_process	branched-chain amino acid catabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
E	0019474	biological_process	L-lysine catabolic process to acetyl-CoA
E	0031410	cellular_component	cytoplasmic vesicle
E	0031514	cellular_component	motile cilium
E	0042391	biological_process	regulation of membrane potential
E	0043159	cellular_component	acrosomal matrix
E	0045252	cellular_component	oxoglutarate dehydrogenase complex
E	0045254	cellular_component	pyruvate dehydrogenase complex
E	0048240	biological_process	sperm capacitation
E	0050660	molecular_function	flavin adenine dinucleotide binding
E	0120551	biological_process	2-oxoglutarate decarboxylation to succinyl-CoA
E	0120552	biological_process	branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA
E	0160157	cellular_component	branched-chain alpha-ketoacid dehydrogenase complex
E	0160167	cellular_component	oxoadipate dehydrogenase complex
F	0001669	cellular_component	acrosomal vesicle
F	0004148	molecular_function	dihydrolipoyl dehydrogenase (NADH) activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0005929	cellular_component	cilium
F	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
F	0006099	biological_process	tricarboxylic acid cycle
F	0006103	biological_process	2-oxoglutarate metabolic process
F	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
F	0006508	biological_process	proteolysis
F	0007369	biological_process	gastrulation
F	0009083	biological_process	branched-chain amino acid catabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
F	0019474	biological_process	L-lysine catabolic process to acetyl-CoA
F	0031410	cellular_component	cytoplasmic vesicle
F	0031514	cellular_component	motile cilium
F	0042391	biological_process	regulation of membrane potential
F	0043159	cellular_component	acrosomal matrix
F	0045252	cellular_component	oxoglutarate dehydrogenase complex
F	0045254	cellular_component	pyruvate dehydrogenase complex
F	0048240	biological_process	sperm capacitation
F	0050660	molecular_function	flavin adenine dinucleotide binding
F	0120551	biological_process	2-oxoglutarate decarboxylation to succinyl-CoA
F	0120552	biological_process	branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA
F	0160157	cellular_component	branched-chain alpha-ketoacid dehydrogenase complex
F	0160167	cellular_component	oxoadipate dehydrogenase complex
G	0001669	cellular_component	acrosomal vesicle
G	0004148	molecular_function	dihydrolipoyl dehydrogenase (NADH) activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0005929	cellular_component	cilium
G	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
G	0006099	biological_process	tricarboxylic acid cycle
G	0006103	biological_process	2-oxoglutarate metabolic process
G	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
G	0006508	biological_process	proteolysis
G	0007369	biological_process	gastrulation
G	0009083	biological_process	branched-chain amino acid catabolic process
G	0016491	molecular_function	oxidoreductase activity
G	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
G	0019474	biological_process	L-lysine catabolic process to acetyl-CoA
G	0031410	cellular_component	cytoplasmic vesicle
G	0031514	cellular_component	motile cilium
G	0042391	biological_process	regulation of membrane potential
G	0043159	cellular_component	acrosomal matrix
G	0045252	cellular_component	oxoglutarate dehydrogenase complex
G	0045254	cellular_component	pyruvate dehydrogenase complex
G	0048240	biological_process	sperm capacitation
G	0050660	molecular_function	flavin adenine dinucleotide binding
G	0120551	biological_process	2-oxoglutarate decarboxylation to succinyl-CoA
G	0120552	biological_process	branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA
G	0160157	cellular_component	branched-chain alpha-ketoacid dehydrogenase complex
G	0160167	cellular_component	oxoadipate dehydrogenase complex
H	0001669	cellular_component	acrosomal vesicle
H	0004148	molecular_function	dihydrolipoyl dehydrogenase (NADH) activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005759	cellular_component	mitochondrial matrix
H	0005929	cellular_component	cilium
H	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
H	0006099	biological_process	tricarboxylic acid cycle
H	0006103	biological_process	2-oxoglutarate metabolic process
H	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
H	0006508	biological_process	proteolysis
H	0007369	biological_process	gastrulation
H	0009083	biological_process	branched-chain amino acid catabolic process
H	0016491	molecular_function	oxidoreductase activity
H	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
H	0019474	biological_process	L-lysine catabolic process to acetyl-CoA
H	0031410	cellular_component	cytoplasmic vesicle
H	0031514	cellular_component	motile cilium
H	0042391	biological_process	regulation of membrane potential
H	0043159	cellular_component	acrosomal matrix
H	0045252	cellular_component	oxoglutarate dehydrogenase complex
H	0045254	cellular_component	pyruvate dehydrogenase complex
H	0048240	biological_process	sperm capacitation
H	0050660	molecular_function	flavin adenine dinucleotide binding
H	0120551	biological_process	2-oxoglutarate decarboxylation to succinyl-CoA
H	0120552	biological_process	branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA
H	0160157	cellular_component	branched-chain alpha-ketoacid dehydrogenase complex
H	0160167	cellular_component	oxoadipate dehydrogenase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	31
Details	binding site for residue FAD A 501

Chain	Residue
A	GLY13
A	CYS45
A	VAL48
A	GLY49
A	CYS50
A	LYS54
A	GLY117
A	TYR118
A	GLY119
A	ALA147
A	THR148
A	GLY15
A	GLY149
A	SER150
A	ILE189
A	ARG280
A	PHE283
A	GLY319
A	ASP320
A	MET326
A	LEU327
A	ALA328
A	PRO16
A	HOH631
B	HOH610
A	GLY17
A	GLU36
A	LYS37
A	ASN38
A	GLY43
A	THR44

---

site_id	AC2
Number of Residues	7
Details	binding site for residue SO4 A 502

Chain	Residue
A	THR284
A	ASN286
A	LEU287
A	GLY288
A	LEU289
A	GLU290
A	HOH622

---

site_id	AC3
Number of Residues	5
Details	binding site for residue SO4 A 503

Chain	Residue
A	LYS111
A	LEU210
A	GLY211
A	HIS212
A	MET220

---

site_id	AC4
Number of Residues	3
Details	binding site for residue SO4 A 504

Chain	Residue
A	HIS64
A	GLY68
A	LYS69

---

site_id	AC5
Number of Residues	5
Details	binding site for residue SO4 A 505

Chain	Residue
A	ARG299
A	ARG301
A	ALA323
A	GLY324
A	HOH612

---

site_id	AC6
Number of Residues	2
Details	binding site for residue SO4 A 506

Chain	Residue
A	HIS105
A	LYS108

---

site_id	AC7
Number of Residues	31
Details	binding site for residue FAD B 501

Chain	Residue
B	ILE12
B	GLY13
B	GLY15
B	PRO16
B	GLY17
B	ILE35
B	GLU36
B	LYS37
B	ASN38
B	GLY43
B	THR44
B	CYS45
B	VAL48
B	GLY49
B	CYS50
B	LYS54
B	TYR118
B	GLY119
B	ALA147
B	THR148
B	GLY149
B	SER150
B	ILE189
B	ARG280
B	PHE283
B	GLY319
B	ASP320
B	MET326
B	LEU327
B	ALA328
B	HIS329

---

site_id	AC8
Number of Residues	3
Details	binding site for residue SO4 B 502

Chain	Residue
B	HIS64
B	GLY68
B	LYS69

---

site_id	AC9
Number of Residues	4
Details	binding site for residue SO4 B 503

Chain	Residue
B	ARG299
B	ARG301
B	GLY324
B	HOH622

---

site_id	AD1
Number of Residues	34
Details	binding site for residue FAD C 501

Chain	Residue
C	GLY43
C	THR44
C	CYS45
C	GLY49
C	CYS50
C	LYS54
C	GLY117
C	TYR118
C	GLY119
C	ALA147
C	THR148
C	GLY149
C	SER150
C	ILE189
C	ARG280
C	PHE283
C	GLY319
C	ASP320
C	MET326
C	LEU327
C	ALA328
C	HIS329
C	ALA331
C	HOH613
C	HOH625
C	HOH626
C	ILE12
C	GLY13
C	GLY15
C	PRO16
C	GLY17
C	GLU36
C	LYS37
C	ASN38

---

site_id	AD2
Number of Residues	7
Details	binding site for residue SO4 C 502

Chain	Residue
C	THR284
C	ASN286
C	LEU287
C	GLY288
C	LEU289
C	GLU290
C	HOH660

---

site_id	AD3
Number of Residues	4
Details	binding site for residue SO4 C 503

Chain	Residue
C	ARG299
C	ARG301
C	GLY324
C	HOH604

---

site_id	AD4
Number of Residues	3
Details	binding site for residue SO4 C 504

Chain	Residue
C	LEU210
C	GLY211
C	HIS212

---

site_id	AD5
Number of Residues	3
Details	binding site for residue SO4 C 505

Chain	Residue
C	HIS64
C	GLY68
C	LYS69

---

site_id	AD6
Number of Residues	2
Details	binding site for residue SO4 C 506

Chain	Residue
C	HIS105
C	LYS108

---

site_id	AD7
Number of Residues	3
Details	binding site for residue SO4 C 507

Chain	Residue
C	LYS124
C	ASN314
F	ARG414

---

site_id	AD8
Number of Residues	30
Details	binding site for residue FAD D 501

Chain	Residue
D	ILE12
D	GLY13
D	GLY15
D	PRO16
D	GLY17
D	GLU36
D	LYS37
D	GLY43
D	THR44
D	CYS45
D	GLY49
D	CYS50
D	LYS54
D	TYR118
D	GLY119
D	ALA147
D	THR148
D	GLY149
D	SER150
D	ILE189
D	ARG280
D	PHE283
D	GLY319
D	ASP320
D	MET326
D	LEU327
D	ALA328
D	HIS329
D	ALA331
D	HOH609

---

site_id	AD9
Number of Residues	3
Details	binding site for residue SO4 D 502

Chain	Residue
D	HIS64
D	GLY68
D	LYS69

---

site_id	AE1
Number of Residues	4
Details	binding site for residue SO4 D 503

Chain	Residue
D	ARG299
D	ARG301
D	ALA323
D	GLY324

---

site_id	AE2
Number of Residues	4
Details	binding site for residue SO4 D 504

Chain	Residue
D	LEU210
D	GLY211
D	HIS212
D	MET220

---

site_id	AE3
Number of Residues	4
Details	binding site for residue SO4 D 505

Chain	Residue
D	THR284
D	ASN286
D	GLY288
D	LEU289

---

site_id	AE4
Number of Residues	30
Details	binding site for residue FAD E 501

Chain	Residue
E	ILE12
E	GLY13
E	GLY15
E	PRO16
E	GLY17
E	GLU36
E	LYS37
E	ASN38
E	GLY43
E	THR44
E	CYS45
E	GLY49
E	CYS50
E	LYS54
E	TYR118
E	GLY119
E	ALA147
E	THR148
E	GLY149
E	SER150
E	ILE189
E	ARG280
E	PHE283
E	GLY319
E	ASP320
E	MET326
E	LEU327
E	ALA328
E	HIS329
E	HOH609

---

site_id	AE5
Number of Residues	6
Details	binding site for residue SO4 E 502

Chain	Residue
E	ASN286
E	LEU287
E	GLY288
E	LEU289
E	GLU290
E	HOH603

---

site_id	AE6
Number of Residues	4
Details	binding site for residue SO4 E 503

Chain	Residue
E	ARG299
E	ARG301
E	ALA323
E	GLY324

---

site_id	AE7
Number of Residues	3
Details	binding site for residue SO4 E 504

Chain	Residue
E	LEU210
E	GLY211
E	HIS212

---

site_id	AE8
Number of Residues	32
Details	binding site for residue FAD F 501

Chain	Residue
F	ILE12
F	GLY13
F	GLY15
F	PRO16
F	GLY17
F	ILE35
F	GLU36
F	LYS37
F	ASN38
F	GLY43
F	THR44
F	CYS45
F	GLY49
F	CYS50
F	LYS54
F	TYR118
F	GLY119
F	ALA147
F	THR148
F	GLY149
F	SER150
F	SER168
F	ILE189
F	ARG280
F	PHE283
F	GLY319
F	ASP320
F	MET326
F	LEU327
F	ALA328
F	HIS329
F	HOH605

---

site_id	AE9
Number of Residues	2
Details	binding site for residue SO4 F 502

Chain	Residue
F	ARG301
F	GLY324

---

site_id	AF1
Number of Residues	6
Details	binding site for residue SO4 F 503

Chain	Residue
F	ASN286
F	LEU287
F	GLY288
F	LEU289
F	GLU290
F	GLU291

---

site_id	AF2
Number of Residues	31
Details	binding site for residue FAD G 501

Chain	Residue
G	ILE12
G	GLY13
G	GLY15
G	PRO16
G	GLY17
G	ILE35
G	GLU36
G	LYS37
G	ASN38
G	GLY43
G	THR44
G	CYS45
G	VAL48
G	GLY49
G	CYS50
G	LYS54
G	TYR118
G	GLY119
G	ALA147
G	THR148
G	GLY149
G	ILE189
G	ARG280
G	PHE283
G	GLY319
G	ASP320
G	MET326
G	LEU327
G	ALA328
G	HIS329
G	HOH603

---

site_id	AF3
Number of Residues	4
Details	binding site for residue SO4 G 502

Chain	Residue
G	ARG299
G	ARG301
G	ALA323
G	GLY324

---

site_id	AF4
Number of Residues	6
Details	binding site for residue SO4 G 503

Chain	Residue
G	ASN286
G	LEU287
G	GLY288
G	LEU289
G	GLU290
G	HOH623

---

site_id	AF5
Number of Residues	2
Details	binding site for residue SO4 G 504

Chain	Residue
G	GLY211
G	HIS212

---

site_id	AF6
Number of Residues	31
Details	binding site for residue FAD H 501

Chain	Residue
H	ILE12
H	GLY13
H	GLY15
H	PRO16
H	GLY17
H	ILE35
H	GLU36
H	LYS37
H	GLY43
H	THR44
H	CYS45
H	VAL48
H	GLY49
H	CYS50
H	LYS54
H	TYR118
H	GLY119
H	ALA147
H	THR148
H	GLY149
H	SER150
H	ILE189
H	ARG280
H	PHE283
H	GLY319
H	ASP320
H	MET326
H	LEU327
H	ALA328
H	HIS329
H	HOH607

---

site_id	AF7
Number of Residues	3
Details	binding site for residue SO4 H 502

Chain	Residue
H	ARG299
H	ARG301
H	GLY324

---

site_id	AF8
Number of Residues	5
Details	binding site for residue SO4 H 503

Chain	Residue
H	THR284
H	LEU287
H	GLY288
H	LEU289
H	GLU290

---

Functional Information from PROSITE/UniProt

site_id	PS00076
Number of Residues	11
Details	PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCLnvGCIP

Chain	Residue	Details
A	GLY42-PRO52

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"P09624","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	216
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15946682","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Site: {"description":"Important for interaction with PDHX and activity of multienzyme pyruvate dehydrogenase complex","evidences":[{"source":"PubMed","id":"20385101","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	56
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"O08749","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	40
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"O08749","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O08749","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q6P6R2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	16
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"O08749","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---