Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6I4Z

Crystal structure of the disease-causing P453L mutant of the human dihydrolipoamide dehydrogenase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001669	cellular_component	acrosomal vesicle
A	0004148	molecular_function	dihydrolipoyl dehydrogenase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005929	cellular_component	cilium
A	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
A	0006090	biological_process	pyruvate metabolic process
A	0006103	biological_process	2-oxoglutarate metabolic process
A	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
A	0006508	biological_process	proteolysis
A	0007369	biological_process	gastrulation
A	0009083	biological_process	branched-chain amino acid catabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
A	0031410	cellular_component	cytoplasmic vesicle
A	0031514	cellular_component	motile cilium
A	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
A	0042391	biological_process	regulation of membrane potential
A	0043159	cellular_component	acrosomal matrix
A	0045252	cellular_component	oxoglutarate dehydrogenase complex
A	0045254	cellular_component	pyruvate dehydrogenase complex
A	0047101	molecular_function	branched-chain alpha-keto acid dehydrogenase activity
A	0048240	biological_process	sperm capacitation
A	0050660	molecular_function	flavin adenine dinucleotide binding
A	0160157	cellular_component	branched-chain alpha-ketoacid dehydrogenase complex
A	0160167	cellular_component	oxoadipate dehydrogenase complex
A	1902493	cellular_component	acetyltransferase complex
B	0001669	cellular_component	acrosomal vesicle
B	0004148	molecular_function	dihydrolipoyl dehydrogenase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005929	cellular_component	cilium
B	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
B	0006090	biological_process	pyruvate metabolic process
B	0006103	biological_process	2-oxoglutarate metabolic process
B	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
B	0006508	biological_process	proteolysis
B	0007369	biological_process	gastrulation
B	0009083	biological_process	branched-chain amino acid catabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
B	0031410	cellular_component	cytoplasmic vesicle
B	0031514	cellular_component	motile cilium
B	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
B	0042391	biological_process	regulation of membrane potential
B	0043159	cellular_component	acrosomal matrix
B	0045252	cellular_component	oxoglutarate dehydrogenase complex
B	0045254	cellular_component	pyruvate dehydrogenase complex
B	0047101	molecular_function	branched-chain alpha-keto acid dehydrogenase activity
B	0048240	biological_process	sperm capacitation
B	0050660	molecular_function	flavin adenine dinucleotide binding
B	0160157	cellular_component	branched-chain alpha-ketoacid dehydrogenase complex
B	0160167	cellular_component	oxoadipate dehydrogenase complex
B	1902493	cellular_component	acetyltransferase complex
C	0001669	cellular_component	acrosomal vesicle
C	0004148	molecular_function	dihydrolipoyl dehydrogenase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005929	cellular_component	cilium
C	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
C	0006090	biological_process	pyruvate metabolic process
C	0006103	biological_process	2-oxoglutarate metabolic process
C	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
C	0006508	biological_process	proteolysis
C	0007369	biological_process	gastrulation
C	0009083	biological_process	branched-chain amino acid catabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
C	0031410	cellular_component	cytoplasmic vesicle
C	0031514	cellular_component	motile cilium
C	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
C	0042391	biological_process	regulation of membrane potential
C	0043159	cellular_component	acrosomal matrix
C	0045252	cellular_component	oxoglutarate dehydrogenase complex
C	0045254	cellular_component	pyruvate dehydrogenase complex
C	0047101	molecular_function	branched-chain alpha-keto acid dehydrogenase activity
C	0048240	biological_process	sperm capacitation
C	0050660	molecular_function	flavin adenine dinucleotide binding
C	0160157	cellular_component	branched-chain alpha-ketoacid dehydrogenase complex
C	0160167	cellular_component	oxoadipate dehydrogenase complex
C	1902493	cellular_component	acetyltransferase complex
D	0001669	cellular_component	acrosomal vesicle
D	0004148	molecular_function	dihydrolipoyl dehydrogenase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0005929	cellular_component	cilium
D	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
D	0006090	biological_process	pyruvate metabolic process
D	0006103	biological_process	2-oxoglutarate metabolic process
D	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
D	0006508	biological_process	proteolysis
D	0007369	biological_process	gastrulation
D	0009083	biological_process	branched-chain amino acid catabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
D	0031410	cellular_component	cytoplasmic vesicle
D	0031514	cellular_component	motile cilium
D	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
D	0042391	biological_process	regulation of membrane potential
D	0043159	cellular_component	acrosomal matrix
D	0045252	cellular_component	oxoglutarate dehydrogenase complex
D	0045254	cellular_component	pyruvate dehydrogenase complex
D	0047101	molecular_function	branched-chain alpha-keto acid dehydrogenase activity
D	0048240	biological_process	sperm capacitation
D	0050660	molecular_function	flavin adenine dinucleotide binding
D	0160157	cellular_component	branched-chain alpha-ketoacid dehydrogenase complex
D	0160167	cellular_component	oxoadipate dehydrogenase complex
D	1902493	cellular_component	acetyltransferase complex
E	0001669	cellular_component	acrosomal vesicle
E	0004148	molecular_function	dihydrolipoyl dehydrogenase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005739	cellular_component	mitochondrion
E	0005759	cellular_component	mitochondrial matrix
E	0005929	cellular_component	cilium
E	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
E	0006090	biological_process	pyruvate metabolic process
E	0006103	biological_process	2-oxoglutarate metabolic process
E	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
E	0006508	biological_process	proteolysis
E	0007369	biological_process	gastrulation
E	0009083	biological_process	branched-chain amino acid catabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
E	0031410	cellular_component	cytoplasmic vesicle
E	0031514	cellular_component	motile cilium
E	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
E	0042391	biological_process	regulation of membrane potential
E	0043159	cellular_component	acrosomal matrix
E	0045252	cellular_component	oxoglutarate dehydrogenase complex
E	0045254	cellular_component	pyruvate dehydrogenase complex
E	0047101	molecular_function	branched-chain alpha-keto acid dehydrogenase activity
E	0048240	biological_process	sperm capacitation
E	0050660	molecular_function	flavin adenine dinucleotide binding
E	0160157	cellular_component	branched-chain alpha-ketoacid dehydrogenase complex
E	0160167	cellular_component	oxoadipate dehydrogenase complex
E	1902493	cellular_component	acetyltransferase complex
F	0001669	cellular_component	acrosomal vesicle
F	0004148	molecular_function	dihydrolipoyl dehydrogenase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0005929	cellular_component	cilium
F	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
F	0006090	biological_process	pyruvate metabolic process
F	0006103	biological_process	2-oxoglutarate metabolic process
F	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
F	0006508	biological_process	proteolysis
F	0007369	biological_process	gastrulation
F	0009083	biological_process	branched-chain amino acid catabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
F	0031410	cellular_component	cytoplasmic vesicle
F	0031514	cellular_component	motile cilium
F	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
F	0042391	biological_process	regulation of membrane potential
F	0043159	cellular_component	acrosomal matrix
F	0045252	cellular_component	oxoglutarate dehydrogenase complex
F	0045254	cellular_component	pyruvate dehydrogenase complex
F	0047101	molecular_function	branched-chain alpha-keto acid dehydrogenase activity
F	0048240	biological_process	sperm capacitation
F	0050660	molecular_function	flavin adenine dinucleotide binding
F	0160157	cellular_component	branched-chain alpha-ketoacid dehydrogenase complex
F	0160167	cellular_component	oxoadipate dehydrogenase complex
F	1902493	cellular_component	acetyltransferase complex
G	0001669	cellular_component	acrosomal vesicle
G	0004148	molecular_function	dihydrolipoyl dehydrogenase activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005739	cellular_component	mitochondrion
G	0005759	cellular_component	mitochondrial matrix
G	0005929	cellular_component	cilium
G	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
G	0006090	biological_process	pyruvate metabolic process
G	0006103	biological_process	2-oxoglutarate metabolic process
G	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
G	0006508	biological_process	proteolysis
G	0007369	biological_process	gastrulation
G	0009083	biological_process	branched-chain amino acid catabolic process
G	0016491	molecular_function	oxidoreductase activity
G	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
G	0031410	cellular_component	cytoplasmic vesicle
G	0031514	cellular_component	motile cilium
G	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
G	0042391	biological_process	regulation of membrane potential
G	0043159	cellular_component	acrosomal matrix
G	0045252	cellular_component	oxoglutarate dehydrogenase complex
G	0045254	cellular_component	pyruvate dehydrogenase complex
G	0047101	molecular_function	branched-chain alpha-keto acid dehydrogenase activity
G	0048240	biological_process	sperm capacitation
G	0050660	molecular_function	flavin adenine dinucleotide binding
G	0160157	cellular_component	branched-chain alpha-ketoacid dehydrogenase complex
G	0160167	cellular_component	oxoadipate dehydrogenase complex
G	1902493	cellular_component	acetyltransferase complex
H	0001669	cellular_component	acrosomal vesicle
H	0004148	molecular_function	dihydrolipoyl dehydrogenase activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005739	cellular_component	mitochondrion
H	0005759	cellular_component	mitochondrial matrix
H	0005929	cellular_component	cilium
H	0006086	biological_process	acetyl-CoA biosynthetic process from pyruvate
H	0006090	biological_process	pyruvate metabolic process
H	0006103	biological_process	2-oxoglutarate metabolic process
H	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
H	0006508	biological_process	proteolysis
H	0007369	biological_process	gastrulation
H	0009083	biological_process	branched-chain amino acid catabolic process
H	0016491	molecular_function	oxidoreductase activity
H	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
H	0031410	cellular_component	cytoplasmic vesicle
H	0031514	cellular_component	motile cilium
H	0034604	molecular_function	pyruvate dehydrogenase (NAD+) activity
H	0042391	biological_process	regulation of membrane potential
H	0043159	cellular_component	acrosomal matrix
H	0045252	cellular_component	oxoglutarate dehydrogenase complex
H	0045254	cellular_component	pyruvate dehydrogenase complex
H	0047101	molecular_function	branched-chain alpha-keto acid dehydrogenase activity
H	0048240	biological_process	sperm capacitation
H	0050660	molecular_function	flavin adenine dinucleotide binding
H	0160157	cellular_component	branched-chain alpha-ketoacid dehydrogenase complex
H	0160167	cellular_component	oxoadipate dehydrogenase complex
H	1902493	cellular_component	acetyltransferase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	31
Details	binding site for residue FAD A 501

Chain	Residue
A	GLY13
A	CYS45
A	VAL48
A	GLY49
A	CYS50
A	LYS54
A	GLY117
A	TYR118
A	GLY119
A	ALA147
A	THR148
A	GLY15
A	GLY149
A	SER150
A	ILE189
A	ARG280
A	PHE283
A	GLY319
A	ASP320
A	MET326
A	LEU327
A	ALA328
A	PRO16
A	HOH631
B	HOH610
A	GLY17
A	GLU36
A	LYS37
A	ASN38
A	GLY43
A	THR44

site_id	AC2
Number of Residues	7
Details	binding site for residue SO4 A 502

Chain	Residue
A	THR284
A	ASN286
A	LEU287
A	GLY288
A	LEU289
A	GLU290
A	HOH622

site_id	AC3
Number of Residues	5
Details	binding site for residue SO4 A 503

Chain	Residue
A	LYS111
A	LEU210
A	GLY211
A	HIS212
A	MET220

site_id	AC4
Number of Residues	3
Details	binding site for residue SO4 A 504

Chain	Residue
A	HIS64
A	GLY68
A	LYS69

site_id	AC5
Number of Residues	5
Details	binding site for residue SO4 A 505

Chain	Residue
A	ARG299
A	ARG301
A	ALA323
A	GLY324
A	HOH612

site_id	AC6
Number of Residues	2
Details	binding site for residue SO4 A 506

Chain	Residue
A	HIS105
A	LYS108

site_id	AC7
Number of Residues	31
Details	binding site for residue FAD B 501

Chain	Residue
B	ILE12
B	GLY13
B	GLY15
B	PRO16
B	GLY17
B	ILE35
B	GLU36
B	LYS37
B	ASN38
B	GLY43
B	THR44
B	CYS45
B	VAL48
B	GLY49
B	CYS50
B	LYS54
B	TYR118
B	GLY119
B	ALA147
B	THR148
B	GLY149
B	SER150
B	ILE189
B	ARG280
B	PHE283
B	GLY319
B	ASP320
B	MET326
B	LEU327
B	ALA328
B	HIS329

site_id	AC8
Number of Residues	3
Details	binding site for residue SO4 B 502

Chain	Residue
B	HIS64
B	GLY68
B	LYS69

site_id	AC9
Number of Residues	4
Details	binding site for residue SO4 B 503

Chain	Residue
B	ARG299
B	ARG301
B	GLY324
B	HOH622

site_id	AD1
Number of Residues	34
Details	binding site for residue FAD C 501

Chain	Residue
C	GLY43
C	THR44
C	CYS45
C	GLY49
C	CYS50
C	LYS54
C	GLY117
C	TYR118
C	GLY119
C	ALA147
C	THR148
C	GLY149
C	SER150
C	ILE189
C	ARG280
C	PHE283
C	GLY319
C	ASP320
C	MET326
C	LEU327
C	ALA328
C	HIS329
C	ALA331
C	HOH613
C	HOH625
C	HOH626
C	ILE12
C	GLY13
C	GLY15
C	PRO16
C	GLY17
C	GLU36
C	LYS37
C	ASN38

site_id	AD2
Number of Residues	7
Details	binding site for residue SO4 C 502

Chain	Residue
C	THR284
C	ASN286
C	LEU287
C	GLY288
C	LEU289
C	GLU290
C	HOH660

site_id	AD3
Number of Residues	4
Details	binding site for residue SO4 C 503

Chain	Residue
C	ARG299
C	ARG301
C	GLY324
C	HOH604

site_id	AD4
Number of Residues	3
Details	binding site for residue SO4 C 504

Chain	Residue
C	LEU210
C	GLY211
C	HIS212

site_id	AD5
Number of Residues	3
Details	binding site for residue SO4 C 505

Chain	Residue
C	HIS64
C	GLY68
C	LYS69

site_id	AD6
Number of Residues	2
Details	binding site for residue SO4 C 506

Chain	Residue
C	HIS105
C	LYS108

site_id	AD7
Number of Residues	3
Details	binding site for residue SO4 C 507

Chain	Residue
C	LYS124
C	ASN314
F	ARG414

site_id	AD8
Number of Residues	30
Details	binding site for residue FAD D 501

Chain	Residue
D	ILE12
D	GLY13
D	GLY15
D	PRO16
D	GLY17
D	GLU36
D	LYS37
D	GLY43
D	THR44
D	CYS45
D	GLY49
D	CYS50
D	LYS54
D	TYR118
D	GLY119
D	ALA147
D	THR148
D	GLY149
D	SER150
D	ILE189
D	ARG280
D	PHE283
D	GLY319
D	ASP320
D	MET326
D	LEU327
D	ALA328
D	HIS329
D	ALA331
D	HOH609

site_id	AD9
Number of Residues	3
Details	binding site for residue SO4 D 502

Chain	Residue
D	HIS64
D	GLY68
D	LYS69

site_id	AE1
Number of Residues	4
Details	binding site for residue SO4 D 503

Chain	Residue
D	ARG299
D	ARG301
D	ALA323
D	GLY324

site_id	AE2
Number of Residues	4
Details	binding site for residue SO4 D 504

Chain	Residue
D	LEU210
D	GLY211
D	HIS212
D	MET220

site_id	AE3
Number of Residues	4
Details	binding site for residue SO4 D 505

Chain	Residue
D	THR284
D	ASN286
D	GLY288
D	LEU289

site_id	AE4
Number of Residues	30
Details	binding site for residue FAD E 501

Chain	Residue
E	ILE12
E	GLY13
E	GLY15
E	PRO16
E	GLY17
E	GLU36
E	LYS37
E	ASN38
E	GLY43
E	THR44
E	CYS45
E	GLY49
E	CYS50
E	LYS54
E	TYR118
E	GLY119
E	ALA147
E	THR148
E	GLY149
E	SER150
E	ILE189
E	ARG280
E	PHE283
E	GLY319
E	ASP320
E	MET326
E	LEU327
E	ALA328
E	HIS329
E	HOH609

site_id	AE5
Number of Residues	6
Details	binding site for residue SO4 E 502

Chain	Residue
E	ASN286
E	LEU287
E	GLY288
E	LEU289
E	GLU290
E	HOH603

site_id	AE6
Number of Residues	4
Details	binding site for residue SO4 E 503

Chain	Residue
E	ARG299
E	ARG301
E	ALA323
E	GLY324

site_id	AE7
Number of Residues	3
Details	binding site for residue SO4 E 504

Chain	Residue
E	LEU210
E	GLY211
E	HIS212

site_id	AE8
Number of Residues	32
Details	binding site for residue FAD F 501

Chain	Residue
F	ILE12
F	GLY13
F	GLY15
F	PRO16
F	GLY17
F	ILE35
F	GLU36
F	LYS37
F	ASN38
F	GLY43
F	THR44
F	CYS45
F	GLY49
F	CYS50
F	LYS54
F	TYR118
F	GLY119
F	ALA147
F	THR148
F	GLY149
F	SER150
F	SER168
F	ILE189
F	ARG280
F	PHE283
F	GLY319
F	ASP320
F	MET326
F	LEU327
F	ALA328
F	HIS329
F	HOH605

site_id	AE9
Number of Residues	2
Details	binding site for residue SO4 F 502

Chain	Residue
F	ARG301
F	GLY324

site_id	AF1
Number of Residues	6
Details	binding site for residue SO4 F 503

Chain	Residue
F	ASN286
F	LEU287
F	GLY288
F	LEU289
F	GLU290
F	GLU291

site_id	AF2
Number of Residues	31
Details	binding site for residue FAD G 501

Chain	Residue
G	ILE12
G	GLY13
G	GLY15
G	PRO16
G	GLY17
G	ILE35
G	GLU36
G	LYS37
G	ASN38
G	GLY43
G	THR44
G	CYS45
G	VAL48
G	GLY49
G	CYS50
G	LYS54
G	TYR118
G	GLY119
G	ALA147
G	THR148
G	GLY149
G	ILE189
G	ARG280
G	PHE283
G	GLY319
G	ASP320
G	MET326
G	LEU327
G	ALA328
G	HIS329
G	HOH603

site_id	AF3
Number of Residues	4
Details	binding site for residue SO4 G 502

Chain	Residue
G	ARG299
G	ARG301
G	ALA323
G	GLY324

site_id	AF4
Number of Residues	6
Details	binding site for residue SO4 G 503

Chain	Residue
G	ASN286
G	LEU287
G	GLY288
G	LEU289
G	GLU290
G	HOH623

site_id	AF5
Number of Residues	2
Details	binding site for residue SO4 G 504

Chain	Residue
G	GLY211
G	HIS212

site_id	AF6
Number of Residues	31
Details	binding site for residue FAD H 501

Chain	Residue
H	ILE12
H	GLY13
H	GLY15
H	PRO16
H	GLY17
H	ILE35
H	GLU36
H	LYS37
H	GLY43
H	THR44
H	CYS45
H	VAL48
H	GLY49
H	CYS50
H	LYS54
H	TYR118
H	GLY119
H	ALA147
H	THR148
H	GLY149
H	SER150
H	ILE189
H	ARG280
H	PHE283
H	GLY319
H	ASP320
H	MET326
H	LEU327
H	ALA328
H	HIS329
H	HOH607

site_id	AF7
Number of Residues	3
Details	binding site for residue SO4 H 502

Chain	Residue
H	ARG299
H	ARG301
H	GLY324

site_id	AF8
Number of Residues	5
Details	binding site for residue SO4 H 503

Chain	Residue
H	THR284
H	LEU287
H	GLY288
H	LEU289
H	GLU290

Functional Information from PROSITE/UniProt

site_id	PS00076
Number of Residues	11
Details	PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCLnvGCIP

Chain	Residue	Details
A	GLY42-PRO52

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Proton acceptor => ECO:0000250\|UniProtKB:P09624

Chain	Residue	Details
A	HIS452
B	HIS452
C	HIS452
D	HIS452
E	HIS452
F	HIS452
G	HIS452
H	HIS452

site_id	SWS_FT_FI2
Number of Residues	80
Details	BINDING: BINDING => ECO:0000269\|PubMed:15946682

Chain	Residue	Details
A	GLU36
A	MET326
B	GLU36
B	LYS54
B	GLY119
B	THR148
B	GLY185
B	GLU208
B	VAL243
B	GLY279
B	ASP320
A	LYS54
B	MET326
C	GLU36
C	LYS54
C	GLY119
C	THR148
C	GLY185
C	GLU208
C	VAL243
C	GLY279
C	ASP320
A	GLY119
C	MET326
D	GLU36
D	LYS54
D	GLY119
D	THR148
D	GLY185
D	GLU208
D	VAL243
D	GLY279
D	ASP320
A	THR148
D	MET326
E	GLU36
E	LYS54
E	GLY119
E	THR148
E	GLY185
E	GLU208
E	VAL243
E	GLY279
E	ASP320
A	GLY185
E	MET326
F	GLU36
F	LYS54
F	GLY119
F	THR148
F	GLY185
F	GLU208
F	VAL243
F	GLY279
F	ASP320
A	GLU208
F	MET326
G	GLU36
G	LYS54
G	GLY119
G	THR148
G	GLY185
G	GLU208
G	VAL243
G	GLY279
G	ASP320
A	VAL243
G	MET326
H	GLU36
H	LYS54
H	GLY119
H	THR148
H	GLY185
H	GLU208
H	VAL243
H	GLY279
H	ASP320
A	GLY279
H	MET326
A	ASP320

site_id	SWS_FT_FI3
Number of Residues	16
Details	SITE: Important for interaction with PDHX and activity of multienzyme pyruvate dehydrogenase complex => ECO:0000269\|PubMed:20385101

Chain	Residue	Details
A	ASP413
E	TYR438
F	ASP413
F	TYR438
G	ASP413
G	TYR438
H	ASP413
H	TYR438
A	TYR438
B	ASP413
B	TYR438
C	ASP413
C	TYR438
D	ASP413
D	TYR438
E	ASP413

site_id	SWS_FT_FI4
Number of Residues	56
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:O08749

Chain	Residue	Details
A	LYS31
B	LYS87
B	LYS97
B	LYS108
B	LYS375
B	LYS470
C	LYS31
C	LYS69
C	LYS87
C	LYS97
C	LYS108
A	LYS69
C	LYS375
C	LYS470
D	LYS31
D	LYS69
D	LYS87
D	LYS97
D	LYS108
D	LYS375
D	LYS470
E	LYS31
A	LYS87
E	LYS69
E	LYS87
E	LYS97
E	LYS108
E	LYS375
E	LYS470
F	LYS31
F	LYS69
F	LYS87
F	LYS97
A	LYS97
F	LYS108
F	LYS375
F	LYS470
G	LYS31
G	LYS69
G	LYS87
G	LYS97
G	LYS108
G	LYS375
G	LYS470
A	LYS108
H	LYS31
H	LYS69
H	LYS87
H	LYS97
H	LYS108
H	LYS375
H	LYS470
A	LYS375
A	LYS470
B	LYS31
B	LYS69

site_id	SWS_FT_FI5
Number of Residues	40
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:O08749

Chain	Residue	Details
A	LYS124
B	LYS395
C	LYS124
C	LYS131
C	LYS238
C	LYS242
C	LYS395
D	LYS124
D	LYS131
D	LYS238
D	LYS242
A	LYS131
D	LYS395
E	LYS124
E	LYS131
E	LYS238
E	LYS242
E	LYS395
F	LYS124
F	LYS131
F	LYS238
F	LYS242
A	LYS238
F	LYS395
G	LYS124
G	LYS131
G	LYS238
G	LYS242
G	LYS395
H	LYS124
H	LYS131
H	LYS238
H	LYS242
A	LYS242
H	LYS395
A	LYS395
B	LYS124
B	LYS131
B	LYS238
B	LYS242

site_id	SWS_FT_FI6
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:O08749

Chain	Residue	Details
A	SER250
B	SER250
C	SER250
D	SER250
E	SER250
F	SER250
G	SER250
H	SER250

site_id	SWS_FT_FI7
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q6P6R2

Chain	Residue	Details
A	SER262
B	SER262
C	SER262
D	SER262
E	SER262
F	SER262
G	SER262
H	SER262

site_id	SWS_FT_FI8
Number of Residues	16
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:O08749

Chain	Residue	Details
A	LYS311
E	LYS385
F	LYS311
F	LYS385
G	LYS311
G	LYS385
H	LYS311
H	LYS385
A	LYS385
B	LYS311
B	LYS385
C	LYS311
C	LYS385
D	LYS311
D	LYS385
E	LYS311

site_id	SWS_FT_FI9
Number of Residues	8
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS382
B	LYS382
C	LYS382
D	LYS382
E	LYS382
F	LYS382
G	LYS382
H	LYS382

site_id	SWS_FT_FI10
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER467
B	SER467
C	SER467
D	SER467
E	SER467
F	SER467
G	SER467
H	SER467

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)