6I4M

Crystal Structure of Plasmodium berghei actin II in the Mg-ADP state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0016787	molecular_function	hydrolase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0035891	biological_process	exit from host cell
A	0044129	biological_process	positive regulation of development of symbiont in host
A	0044782	biological_process	cilium organization
A	0048232	biological_process	male gamete generation
G	0051015	molecular_function	actin filament binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	28
Details	binding site for residue ADP A 401

Chain	Residue
A	GLY13
A	LYS213
A	GLU214
A	GLY302
A	GLY303
A	THR304
A	MET306
A	TYR307
A	LYS337
A	MG402
A	HOH551
A	SER14
A	HOH569
A	HOH570
A	HOH577
A	HOH592
A	HOH606
A	HOH629
A	HOH652
A	HOH696
A	HOH713
A	GLY15
A	MET16
A	LYS18
A	GLY156
A	ASP157
A	GLY182
A	ARG210

---

site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 402

Chain	Residue
A	ADP401
A	HOH506
A	HOH570
A	HOH577
A	HOH592
A	HOH696

---

site_id	AC3
Number of Residues	7
Details	binding site for residue SCN A 403

Chain	Residue
A	ALA144
A	SER145
A	PRO333
A	GLU335
A	HOH586
A	HOH678
G	GLN71

---

site_id	AC4
Number of Residues	6
Details	binding site for residue SCN A 404

Chain	Residue
A	ARG62
A	MET284
A	ARG291
A	TYR295
A	PRO323
A	HOH614

---

site_id	AC5
Number of Residues	6
Details	binding site for residue CA G 201

Chain	Residue
A	GLU167
G	ASP85
G	GLY90
G	ALA92
G	HOH391
G	HOH393

---

site_id	AC6
Number of Residues	6
Details	binding site for residue CA G 202

Chain	Residue
G	GLY41
G	ASP42
G	GLU73
G	VAL121
G	HOH373
G	HOH380

---

Functional Information from PROSITE/UniProt

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQn.KRG

Chain	Residue	Details
A	TYR53-GLY63

---

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WITKeEYDE

Chain	Residue	Details
A	TRP357-GLU365

---

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPktNR

Chain	Residue	Details
A	LEU104-ARG116

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24743229","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31199804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4CBX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24743229","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4CBX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"PubMed","id":"31199804","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	81
Details	Repeat: {"description":"Gelsolin-like 1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	123
Details	Region: {"description":"Actin-severing","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Region: {"description":"Actin-actin interfilament contact point"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24743229","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28695858","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31199804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4CBU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CBW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CBX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MVV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24743229","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31199804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4CBU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CBW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CBX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	7
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P06396","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---