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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6I2T

CryoEM reconstruction of full-length, fully-glycosylated human butyrylcholinesterase tetramer

Functional Information from GO Data
ChainGOidnamespacecontents
A0001540molecular_functionamyloid-beta binding
A0003824molecular_functioncatalytic activity
A0003990molecular_functionacetylcholinesterase activity
A0004104molecular_functioncholinesterase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005641cellular_componentnuclear envelope lumen
A0005783cellular_componentendoplasmic reticulum
A0005788cellular_componentendoplasmic reticulum lumen
A0005886cellular_componentplasma membrane
A0006581biological_processacetylcholine catabolic process
A0006805biological_processxenobiotic metabolic process
A0007584biological_processresponse to nutrient
A0007612biological_processlearning
A0008285biological_processnegative regulation of cell population proliferation
A0009410biological_processresponse to xenobiotic stimulus
A0014016biological_processneuroblast differentiation
A0016486biological_processpeptide hormone processing
A0016787molecular_functionhydrolase activity
A0016788molecular_functionhydrolase activity, acting on ester bonds
A0019695biological_processcholine metabolic process
A0019899molecular_functionenzyme binding
A0033265molecular_functioncholine binding
A0042802molecular_functionidentical protein binding
A0043279biological_processresponse to alkaloid
A0050784biological_processcocaine catabolic process
A0050805biological_processnegative regulation of synaptic transmission
A0051384biological_processresponse to glucocorticoid
A0051593biological_processresponse to folic acid
A0052689molecular_functioncarboxylic ester hydrolase activity
A0072562cellular_componentblood microparticle
B0001540molecular_functionamyloid-beta binding
B0003824molecular_functioncatalytic activity
B0003990molecular_functionacetylcholinesterase activity
B0004104molecular_functioncholinesterase activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005641cellular_componentnuclear envelope lumen
B0005783cellular_componentendoplasmic reticulum
B0005788cellular_componentendoplasmic reticulum lumen
B0005886cellular_componentplasma membrane
B0006581biological_processacetylcholine catabolic process
B0006805biological_processxenobiotic metabolic process
B0007584biological_processresponse to nutrient
B0007612biological_processlearning
B0008285biological_processnegative regulation of cell population proliferation
B0009410biological_processresponse to xenobiotic stimulus
B0014016biological_processneuroblast differentiation
B0016486biological_processpeptide hormone processing
B0016787molecular_functionhydrolase activity
B0016788molecular_functionhydrolase activity, acting on ester bonds
B0019695biological_processcholine metabolic process
B0019899molecular_functionenzyme binding
B0033265molecular_functioncholine binding
B0042802molecular_functionidentical protein binding
B0043279biological_processresponse to alkaloid
B0050784biological_processcocaine catabolic process
B0050805biological_processnegative regulation of synaptic transmission
B0051384biological_processresponse to glucocorticoid
B0051593biological_processresponse to folic acid
B0052689molecular_functioncarboxylic ester hydrolase activity
B0072562cellular_componentblood microparticle
C0001540molecular_functionamyloid-beta binding
C0003824molecular_functioncatalytic activity
C0003990molecular_functionacetylcholinesterase activity
C0004104molecular_functioncholinesterase activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005641cellular_componentnuclear envelope lumen
C0005783cellular_componentendoplasmic reticulum
C0005788cellular_componentendoplasmic reticulum lumen
C0005886cellular_componentplasma membrane
C0006581biological_processacetylcholine catabolic process
C0006805biological_processxenobiotic metabolic process
C0007584biological_processresponse to nutrient
C0007612biological_processlearning
C0008285biological_processnegative regulation of cell population proliferation
C0009410biological_processresponse to xenobiotic stimulus
C0014016biological_processneuroblast differentiation
C0016486biological_processpeptide hormone processing
C0016787molecular_functionhydrolase activity
C0016788molecular_functionhydrolase activity, acting on ester bonds
C0019695biological_processcholine metabolic process
C0019899molecular_functionenzyme binding
C0033265molecular_functioncholine binding
C0042802molecular_functionidentical protein binding
C0043279biological_processresponse to alkaloid
C0050784biological_processcocaine catabolic process
C0050805biological_processnegative regulation of synaptic transmission
C0051384biological_processresponse to glucocorticoid
C0051593biological_processresponse to folic acid
C0052689molecular_functioncarboxylic ester hydrolase activity
C0072562cellular_componentblood microparticle
D0001540molecular_functionamyloid-beta binding
D0003824molecular_functioncatalytic activity
D0003990molecular_functionacetylcholinesterase activity
D0004104molecular_functioncholinesterase activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005641cellular_componentnuclear envelope lumen
D0005783cellular_componentendoplasmic reticulum
D0005788cellular_componentendoplasmic reticulum lumen
D0005886cellular_componentplasma membrane
D0006581biological_processacetylcholine catabolic process
D0006805biological_processxenobiotic metabolic process
D0007584biological_processresponse to nutrient
D0007612biological_processlearning
D0008285biological_processnegative regulation of cell population proliferation
D0009410biological_processresponse to xenobiotic stimulus
D0014016biological_processneuroblast differentiation
D0016486biological_processpeptide hormone processing
D0016787molecular_functionhydrolase activity
D0016788molecular_functionhydrolase activity, acting on ester bonds
D0019695biological_processcholine metabolic process
D0019899molecular_functionenzyme binding
D0033265molecular_functioncholine binding
D0042802molecular_functionidentical protein binding
D0043279biological_processresponse to alkaloid
D0050784biological_processcocaine catabolic process
D0050805biological_processnegative regulation of synaptic transmission
D0051384biological_processresponse to glucocorticoid
D0051593biological_processresponse to folic acid
D0052689molecular_functioncarboxylic ester hydrolase activity
D0072562cellular_componentblood microparticle
Functional Information from PROSITE/UniProt
site_idPS00122
Number of Residues16
DetailsCARBOXYLESTERASE_B_1 Carboxylesterases type-B serine active site. FGGnpksVtLfGeSAG
ChainResidueDetails
BPHE185-GLY200
site_idPS00941
Number of Residues11
DetailsCARBOXYLESTERASE_B_2 Carboxylesterases type-B signature 2. EDCLYLNVWiP
ChainResidueDetails
BGLU90-PRO100
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsActive site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU10039","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12869558","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues8
DetailsActive site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"12869558","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PDB","id":"4BDS","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsBinding site: {}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22444575","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues8
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18203274","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues8
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"12869558","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15667209","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17355286","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17768338","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18203274","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18975951","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19368529","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23679855","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"12869558","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15667209","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17355286","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17768338","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18203274","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18975951","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19368529","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23679855","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"12869558","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15667209","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17355286","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18203274","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19368529","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23679855","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"18203274","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18975951","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19368529","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23679855","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues8
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14760718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3542989","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12869558","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15667209","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17355286","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17768338","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18975951","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19368529","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23679855","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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