6I1N
Plasmodium falciparum spermidine synthase in complex with N-(3-aminopropyl)-trans-cyclohexane-1,4-diamine
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004766 | molecular_function | spermidine synthase activity |
A | 0005829 | cellular_component | cytosol |
A | 0006596 | biological_process | polyamine biosynthetic process |
A | 0008295 | biological_process | spermidine biosynthetic process |
A | 0016740 | molecular_function | transferase activity |
B | 0003824 | molecular_function | catalytic activity |
B | 0004766 | molecular_function | spermidine synthase activity |
B | 0005829 | cellular_component | cytosol |
B | 0006596 | biological_process | polyamine biosynthetic process |
B | 0008295 | biological_process | spermidine biosynthetic process |
B | 0016740 | molecular_function | transferase activity |
C | 0003824 | molecular_function | catalytic activity |
C | 0004766 | molecular_function | spermidine synthase activity |
C | 0005829 | cellular_component | cytosol |
C | 0006596 | biological_process | polyamine biosynthetic process |
C | 0008295 | biological_process | spermidine biosynthetic process |
C | 0016740 | molecular_function | transferase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | binding site for residue 1PG A 401 |
Chain | Residue |
A | SER45 |
A | SER45 |
A | PHE47 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue JFQ A 402 |
Chain | Residue |
A | GLN72 |
A | LEU88 |
A | GLY124 |
A | GLU147 |
A | ILE148 |
A | ALA179 |
site_id | AC3 |
Number of Residues | 8 |
Details | binding site for residue JFQ B 401 |
Chain | Residue |
B | GLN93 |
B | GLY124 |
B | GLY125 |
B | GLU147 |
B | ILE148 |
B | ASP178 |
B | ALA179 |
B | ASP196 |
site_id | AC4 |
Number of Residues | 11 |
Details | binding site for residue JFQ B 402 |
Chain | Residue |
B | VAL91 |
B | GLN93 |
B | TYR102 |
B | HIS103 |
B | ASP127 |
B | ASP196 |
B | SER198 |
B | GLN229 |
B | TYR264 |
B | HOH544 |
B | HOH607 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue GOL B 403 |
Chain | Residue |
B | LYS97 |
B | LYS297 |
B | HOH520 |
B | HOH534 |
B | HOH542 |
C | TRP234 |
site_id | AC6 |
Number of Residues | 8 |
Details | binding site for residue 1PG B 404 |
Chain | Residue |
B | LYS42 |
B | TRP43 |
B | SER45 |
B | PHE47 |
B | SER57 |
C | SER45 |
C | PHE47 |
C | SER57 |
site_id | AC7 |
Number of Residues | 11 |
Details | binding site for residue JFQ C 501 |
Chain | Residue |
C | VAL91 |
C | GLN93 |
C | TYR102 |
C | HIS103 |
C | ASP127 |
C | ASP196 |
C | TYR264 |
C | ILE269 |
C | JFQ502 |
C | HOH644 |
C | HOH694 |
site_id | AC8 |
Number of Residues | 11 |
Details | binding site for residue JFQ C 502 |
Chain | Residue |
C | GLY124 |
C | GLY125 |
C | CYS146 |
C | GLU147 |
C | ILE148 |
C | ASP178 |
C | ALA179 |
C | ASP196 |
C | SER197 |
C | JFQ501 |
C | HOH632 |
site_id | AC9 |
Number of Residues | 5 |
Details | binding site for residue GOL C 503 |
Chain | Residue |
B | TRP234 |
B | PHE313 |
C | LYS97 |
C | HOH625 |
C | HOH627 |
Functional Information from PROSITE/UniProt
site_id | PS01330 |
Number of Residues | 14 |
Details | PABS_1 Polyamine biosynthesis (PABS) domain signature. VLVVGGGdGgiIrE |
Chain | Residue | Details |
A | VAL120-GLU133 |