6HZC

X-ray structure of furin in complex with the cyclic inhibitor c[glutaryl-BVK-Lys-Arg-Arg-Tle-Lys]-4-Amba

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CA A 601

Chain	Residue
A	ASP174
A	ASP179
A	ASP181
A	HOH868
A	HOH872
A	HOH1043

---

site_id	AC2
Number of Residues	6
Details	binding site for residue CA A 602

Chain	Residue
A	ASN208
A	VAL210
A	GLY212
A	ASP115
A	ASP162
A	VAL205

---

site_id	AC3
Number of Residues	6
Details	binding site for residue CA A 603

Chain	Residue
A	ASP258
A	ASP301
A	GLU331
A	HOH809
A	HOH838
A	HOH890

---

site_id	AC4
Number of Residues	4
Details	binding site for residue NA A 604

Chain	Residue
A	THR309
A	SER311
A	THR314
A	HOH867

---

site_id	AC5
Number of Residues	7
Details	binding site for residue NA A 605

Chain	Residue
A	SER279
A	GLY284
A	HOH757
A	HOH775
A	HOH819
A	HOH1060
A	HOH1065

---

site_id	AC6
Number of Residues	4
Details	binding site for residue NA A 606

Chain	Residue
A	SER544
A	SER544
A	HOH812
A	HOH812

---

site_id	AC7
Number of Residues	3
Details	binding site for residue CL A 607

Chain	Residue
A	ARG276
A	LYS449
A	TYR571

---

site_id	AC8
Number of Residues	4
Details	binding site for residue PO4 A 608

Chain	Residue
A	PHE118
A	PRO119
A	GLN121
A	SER125

---

site_id	AC9
Number of Residues	6
Details	binding site for residue PO4 A 609

Chain	Residue
A	VAL326
A	GLN346
A	ASN347
A	ALA408
A	ASN409
A	HOH965

---

site_id	AD1
Number of Residues	5
Details	binding site for residue DMS A 610

Chain	Residue
A	VAL263
A	GLY527
A	PHE528
A	ASN529
A	HOH761

---

site_id	AD2
Number of Residues	3
Details	binding site for residues PTD B 101 and BVK B 102

Chain	Residue
A	ASN192
A	LEU227
B	LYS5

---

Functional Information from PROSITE/UniProt

site_id	PS00136
Number of Residues	12
Details	SUBTILASE_ASP Serine proteases, subtilase family, aspartic acid active site. VSILDDGIeknH

Chain	Residue	Details
A	VAL149-HIS160

---

site_id	PS00137
Number of Residues	11
Details	SUBTILASE_HIS Serine proteases, subtilase family, histidine active site. HGTrCAGeVAA

Chain	Residue	Details
A	HIS194-ALA204

---

site_id	PS00138
Number of Residues	11
Details	SUBTILASE_SER Serine proteases, subtilase family, serine active site. GTSaSaPlAAG

Chain	Residue	Details
A	GLY366-GLY376

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	314
Details	Domain: {"description":"Peptidase S8","evidences":[{"source":"PROSITE-ProRule","id":"PRU01240","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	132
Details	Domain: {"description":"P/Homo B","evidences":[{"source":"PROSITE-ProRule","id":"PRU01173","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	21
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Motif: {"description":"Cell attachment site","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PROSITE-ProRule","id":"PRU01240","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24666235","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25974265","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4OMC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OMD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RYD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24666235","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25974265","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4OMC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OMD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RYD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---