Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6HYE

PDX1.2/PDX1.3 complex (PDX1.3:K97A)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006520	biological_process	amino acid metabolic process
A	0008615	biological_process	pyridoxine biosynthetic process
A	0016843	molecular_function	amine-lyase activity
A	0042819	biological_process	vitamin B6 biosynthetic process
A	0042823	biological_process	pyridoxal phosphate biosynthetic process
A	0046982	molecular_function	protein heterodimerization activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006520	biological_process	amino acid metabolic process
B	0006979	biological_process	response to oxidative stress
B	0006982	biological_process	response to lipid hydroperoxide
B	0008615	biological_process	pyridoxine biosynthetic process
B	0009651	biological_process	response to salt stress
B	0010224	biological_process	response to UV-B
B	0010335	biological_process	response to non-ionic osmotic stress
B	0012505	cellular_component	endomembrane system
B	0015994	biological_process	chlorophyll metabolic process
B	0016020	cellular_component	membrane
B	0016829	molecular_function	lyase activity
B	0016843	molecular_function	amine-lyase activity
B	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
B	0042538	biological_process	hyperosmotic salinity response
B	0042803	molecular_function	protein homodimerization activity
B	0042819	biological_process	vitamin B6 biosynthetic process
B	0042823	biological_process	pyridoxal phosphate biosynthetic process
B	0046982	molecular_function	protein heterodimerization activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006520	biological_process	amino acid metabolic process
C	0008615	biological_process	pyridoxine biosynthetic process
C	0016843	molecular_function	amine-lyase activity
C	0042819	biological_process	vitamin B6 biosynthetic process
C	0042823	biological_process	pyridoxal phosphate biosynthetic process
C	0046982	molecular_function	protein heterodimerization activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006520	biological_process	amino acid metabolic process
D	0006979	biological_process	response to oxidative stress
D	0006982	biological_process	response to lipid hydroperoxide
D	0008615	biological_process	pyridoxine biosynthetic process
D	0009651	biological_process	response to salt stress
D	0010224	biological_process	response to UV-B
D	0010335	biological_process	response to non-ionic osmotic stress
D	0012505	cellular_component	endomembrane system
D	0015994	biological_process	chlorophyll metabolic process
D	0016020	cellular_component	membrane
D	0016829	molecular_function	lyase activity
D	0016843	molecular_function	amine-lyase activity
D	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
D	0042538	biological_process	hyperosmotic salinity response
D	0042803	molecular_function	protein homodimerization activity
D	0042819	biological_process	vitamin B6 biosynthetic process
D	0042823	biological_process	pyridoxal phosphate biosynthetic process
D	0046982	molecular_function	protein heterodimerization activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006520	biological_process	amino acid metabolic process
E	0008615	biological_process	pyridoxine biosynthetic process
E	0016843	molecular_function	amine-lyase activity
E	0042819	biological_process	vitamin B6 biosynthetic process
E	0042823	biological_process	pyridoxal phosphate biosynthetic process
E	0046982	molecular_function	protein heterodimerization activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006520	biological_process	amino acid metabolic process
F	0006979	biological_process	response to oxidative stress
F	0006982	biological_process	response to lipid hydroperoxide
F	0008615	biological_process	pyridoxine biosynthetic process
F	0009651	biological_process	response to salt stress
F	0010224	biological_process	response to UV-B
F	0010335	biological_process	response to non-ionic osmotic stress
F	0012505	cellular_component	endomembrane system
F	0015994	biological_process	chlorophyll metabolic process
F	0016020	cellular_component	membrane
F	0016829	molecular_function	lyase activity
F	0016843	molecular_function	amine-lyase activity
F	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
F	0042538	biological_process	hyperosmotic salinity response
F	0042803	molecular_function	protein homodimerization activity
F	0042819	biological_process	vitamin B6 biosynthetic process
F	0042823	biological_process	pyridoxal phosphate biosynthetic process
F	0046982	molecular_function	protein heterodimerization activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006520	biological_process	amino acid metabolic process
G	0008615	biological_process	pyridoxine biosynthetic process
G	0016843	molecular_function	amine-lyase activity
G	0042819	biological_process	vitamin B6 biosynthetic process
G	0042823	biological_process	pyridoxal phosphate biosynthetic process
G	0046982	molecular_function	protein heterodimerization activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006520	biological_process	amino acid metabolic process
H	0006979	biological_process	response to oxidative stress
H	0006982	biological_process	response to lipid hydroperoxide
H	0008615	biological_process	pyridoxine biosynthetic process
H	0009651	biological_process	response to salt stress
H	0010224	biological_process	response to UV-B
H	0010335	biological_process	response to non-ionic osmotic stress
H	0012505	cellular_component	endomembrane system
H	0015994	biological_process	chlorophyll metabolic process
H	0016020	cellular_component	membrane
H	0016829	molecular_function	lyase activity
H	0016843	molecular_function	amine-lyase activity
H	0036381	molecular_function	pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
H	0042538	biological_process	hyperosmotic salinity response
H	0042803	molecular_function	protein homodimerization activity
H	0042819	biological_process	vitamin B6 biosynthetic process
H	0042823	biological_process	pyridoxal phosphate biosynthetic process
H	0046982	molecular_function	protein heterodimerization activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue SO4 A 401

Chain	Residue
A	PHE135
A	GLU154
A	ARG157
A	ARG158
B	HIS131
B	ARG153
B	ARG154
C	LYS208
D	LYS203

site_id	AC2
Number of Residues	8
Details	binding site for residue SO4 C 401

Chain	Residue
A	LYS208
B	LYS203
C	PHE135
C	ARG157
C	ARG158
D	HIS131
D	ARG153
D	ARG154

site_id	AC3
Number of Residues	10
Details	binding site for residue SO4 B 401

Chain	Residue
A	GLY234
A	GLY235
A	GLY256
B	PRO65
B	GLU167
B	ALA168
B	GLY169
B	GLY229
B	GLY230
B	GLY251

site_id	AC4
Number of Residues	9
Details	binding site for residue SO4 D 401

Chain	Residue
C	GLU48
C	GLY235
C	GLY256
D	LYS165
D	GLU167
D	ALA168
D	GLY169
D	GLY230
D	GLY251

site_id	AC5
Number of Residues	9
Details	binding site for residue SO4 F 401

Chain	Residue
E	PHE135
E	ARG157
E	ARG158
F	HIS131
F	GLU150
F	ARG153
F	ARG154
G	LYS208
H	LYS203

site_id	AC6
Number of Residues	9
Details	binding site for residue SO4 F 402

Chain	Residue
E	THR173
E	GLY235
E	GLY256
F	LYS165
F	GLU167
F	ALA168
F	GLY169
F	GLY230
F	GLY251

site_id	AC7
Number of Residues	9
Details	binding site for residue SO4 H 401

Chain	Residue
E	LYS208
E	HOH405
F	LYS203
G	PHE135
G	ARG157
G	ARG158
H	GLU150
H	ARG153
H	ARG154

site_id	AC8
Number of Residues	9
Details	binding site for residue SO4 H 402

Chain	Residue
G	GLY234
G	GLY235
G	GLY256
H	GLU167
H	ALA168
H	GLY169
H	GLY229
H	GLY230
H	GLY251

Functional Information from PROSITE/UniProt

site_id	PS01235
Number of Residues	19
Details	PDXS_SNZ_1 PdxS/SNZ family signature. VPVVQFASGGITTPADAAL

Chain	Residue	Details
A	VAL226-LEU244
B	LEU221-LEU239

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Schiff-base intermediate with D-ribose 5-phosphate => ECO:0000250\|UniProtKB:O59080

Chain	Residue	Details
B	ALA97
D	ALA97
F	ALA97
H	ALA97

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:O59080

Chain	Residue	Details
B	ASP40
F	GLY169
F	GLY230
F	GLY251
H	ASP40
H	GLY169
H	GLY230
H	GLY251
B	GLY169
B	GLY230
B	GLY251
D	ASP40
D	GLY169
D	GLY230
D	GLY251
F	ASP40

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q03148

Chain	Residue	Details
B	ARG181
D	ARG181
F	ARG181
H	ARG181

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N-acetylmethionine => ECO:0007744\|PubMed:22223895

Chain	Residue	Details
B	MET1
D	MET1
F	MET1
H	MET1

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)