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6HY2

Structure guided design of an antibacterial peptide that targets UDP-N-acetylglucosamine acyltransferase

Functional Information from GO Data
ChainGOidnamespacecontents
X0005737cellular_componentcytoplasm
X0005829cellular_componentcytosol
X0008610biological_processlipid biosynthetic process
X0008780molecular_functionacyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity
X0009245biological_processlipid A biosynthetic process
X0016740molecular_functiontransferase activity
X0016746molecular_functionacyltransferase activity
X0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
X0042802molecular_functionidentical protein binding
Functional Information from PROSITE/UniProt
site_idPS00101
Number of Residues29
DetailsHEXAPEP_TRANSFERASES Hexapeptide-repeat containing-transferases signature. IGanAhIgpfCiVGphVeIGegTvLkshV
ChainResidueDetails
XILE20-VAL48
XILE153-VAL181

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING:
ChainResidueDetails
XGLN73
XHIS125
XHIS144
XGLN161

Catalytic Information from CSA
site_idMCSA1
Number of Residues3
DetailsM-CSA 69
ChainResidueDetails
XHIS125hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
XASP126electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
XGLY143electrostatic stabiliser, hydrogen bond donor

226707

PDB entries from 2024-10-30

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