Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6HXJ

Structure of ATP citrate lyase from Chlorobium limicola in complex with citrate and coenzyme A.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0003878	molecular_function	ATP citrate synthase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006085	biological_process	acetyl-CoA biosynthetic process
A	0006099	biological_process	tricarboxylic acid cycle
A	0006629	biological_process	lipid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016829	molecular_function	lyase activity
A	0016874	molecular_function	ligase activity
A	0046872	molecular_function	metal ion binding
A	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
B	0003824	molecular_function	catalytic activity
B	0003878	molecular_function	ATP citrate synthase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006085	biological_process	acetyl-CoA biosynthetic process
B	0006099	biological_process	tricarboxylic acid cycle
B	0006629	biological_process	lipid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016829	molecular_function	lyase activity
B	0046872	molecular_function	metal ion binding
B	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
C	0003824	molecular_function	catalytic activity
C	0003878	molecular_function	ATP citrate synthase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006085	biological_process	acetyl-CoA biosynthetic process
C	0006099	biological_process	tricarboxylic acid cycle
C	0006629	biological_process	lipid metabolic process
C	0006633	biological_process	fatty acid biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016829	molecular_function	lyase activity
C	0016874	molecular_function	ligase activity
C	0046872	molecular_function	metal ion binding
C	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
D	0003824	molecular_function	catalytic activity
D	0003878	molecular_function	ATP citrate synthase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006085	biological_process	acetyl-CoA biosynthetic process
D	0006099	biological_process	tricarboxylic acid cycle
D	0006629	biological_process	lipid metabolic process
D	0006633	biological_process	fatty acid biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016829	molecular_function	lyase activity
D	0046872	molecular_function	metal ion binding
D	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
E	0003824	molecular_function	catalytic activity
E	0003878	molecular_function	ATP citrate synthase activity
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006085	biological_process	acetyl-CoA biosynthetic process
E	0006099	biological_process	tricarboxylic acid cycle
E	0006629	biological_process	lipid metabolic process
E	0006633	biological_process	fatty acid biosynthetic process
E	0016740	molecular_function	transferase activity
E	0016829	molecular_function	lyase activity
E	0016874	molecular_function	ligase activity
E	0046872	molecular_function	metal ion binding
E	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
F	0003824	molecular_function	catalytic activity
F	0003878	molecular_function	ATP citrate synthase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006085	biological_process	acetyl-CoA biosynthetic process
F	0006099	biological_process	tricarboxylic acid cycle
F	0006629	biological_process	lipid metabolic process
F	0006633	biological_process	fatty acid biosynthetic process
F	0016740	molecular_function	transferase activity
F	0016829	molecular_function	lyase activity
F	0046872	molecular_function	metal ion binding
F	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
G	0003824	molecular_function	catalytic activity
G	0003878	molecular_function	ATP citrate synthase activity
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006085	biological_process	acetyl-CoA biosynthetic process
G	0006099	biological_process	tricarboxylic acid cycle
G	0006629	biological_process	lipid metabolic process
G	0006633	biological_process	fatty acid biosynthetic process
G	0016740	molecular_function	transferase activity
G	0016829	molecular_function	lyase activity
G	0016874	molecular_function	ligase activity
G	0046872	molecular_function	metal ion binding
G	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer
H	0003824	molecular_function	catalytic activity
H	0003878	molecular_function	ATP citrate synthase activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006085	biological_process	acetyl-CoA biosynthetic process
H	0006099	biological_process	tricarboxylic acid cycle
H	0006629	biological_process	lipid metabolic process
H	0006633	biological_process	fatty acid biosynthetic process
H	0016740	molecular_function	transferase activity
H	0016829	molecular_function	lyase activity
H	0046872	molecular_function	metal ion binding
H	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue FLC A 1001

Chain	Residue
A	SER292
A	GLY293
A	ALA323
A	ASN324
A	PHE325
A	THR326
A	ARG357

site_id	AC2
Number of Residues	7
Details	binding site for residue COA B 1001

Chain	Residue
B	VAL486
B	ILE489
B	LYS534
B	LYS535
B	LEU538
B	LYS480
B	PRO485

site_id	AC3
Number of Residues	11
Details	binding site for residue COA B 1002

Chain	Residue
B	TYR44
B	PRO45
B	PRO46
B	TYR85
B	LEU86
B	GLY87
B	ARG90
B	ILE110
B	GLU112
B	HOH1125
H	LYS480

site_id	AC4
Number of Residues	10
Details	binding site for residue FLC B 1003

Chain	Residue
B	HIS415
B	VAL419
B	PHE450
B	GLY451
B	HIS491
B	ARG502
B	ASP543
B	ARG568
B	HOH1118
F	ARG588

site_id	AC5
Number of Residues	1
Details	binding site for residue PGE B 1004

Chain	Residue
B	LYS219

site_id	AC6
Number of Residues	8
Details	binding site for residue TRS B 1005

Chain	Residue
B	GLU53
B	HOH1115
D	TYR590
D	HOH1116
D	HOH1118
F	GLU352
F	PRO353
F	ARG356

site_id	AC7
Number of Residues	8
Details	binding site for residue FLC C 1001

Chain	Residue
C	SER292
C	GLY293
C	ALA323
C	ASN324
C	PHE325
C	THR326
C	ARG357
D	TRS1004

site_id	AC8
Number of Residues	4
Details	binding site for residue PG4 C 1002

Chain	Residue
C	ALA103
C	LYS196
C	HOH1103
C	HOH1105

site_id	AC9
Number of Residues	3
Details	binding site for residue PGE C 1003

Chain	Residue
C	ALA2
C	GLN185
C	TYR212

site_id	AD1
Number of Residues	8
Details	binding site for residue COA D 1001

Chain	Residue
D	LYS480
D	PRO485
D	VAL486
D	ILE489
D	LYS534
D	LYS535
D	LEU538
E	LYS248

site_id	AD2
Number of Residues	9
Details	binding site for residue COA D 1002

Chain	Residue
D	TYR44
D	PRO45
D	PRO46
D	TYR85
D	LEU86
D	GLY87
D	ARG90
D	ILE110
D	GLU112

site_id	AD3
Number of Residues	9
Details	binding site for residue FLC D 1003

Chain	Residue
D	HIS415
D	VAL419
D	PHE450
D	GLY451
D	HIS491
D	ARG502
D	ASP543
D	ARG568
H	ARG588

site_id	AD4
Number of Residues	7
Details	binding site for residue TRS D 1004

Chain	Residue
C	GLY268
C	GLY269
C	FLC1001
D	SER176
D	GLY177
D	GLY178
D	HOH1115

site_id	AD5
Number of Residues	4
Details	binding site for residue PG4 D 1005

Chain	Residue
B	LYS394
B	LYS395
D	LYS599
F	GLY49

site_id	AD6
Number of Residues	4
Details	binding site for residue PGE D 1006

Chain	Residue
D	LYS313
D	ARG294
D	GLY297
D	TYR299

site_id	AD7
Number of Residues	7
Details	binding site for residue FLC E 1001

Chain	Residue
E	SER292
E	GLY293
E	ALA323
E	ASN324
E	PHE325
E	THR326
E	ARG357

site_id	AD8
Number of Residues	7
Details	binding site for residue COA F 1001

Chain	Residue
F	LYS480
F	PRO485
F	VAL486
F	ILE489
F	LYS534
F	LYS535
F	LEU538

site_id	AD9
Number of Residues	10
Details	binding site for residue COA F 1002

Chain	Residue
F	TYR44
F	PRO45
F	PRO46
F	TYR85
F	LEU86
F	GLY87
F	ARG90
F	ILE110
F	GLU112
F	HOH1106

site_id	AE1
Number of Residues	9
Details	binding site for residue FLC F 1003

Chain	Residue
B	ARG588
F	HIS415
F	VAL419
F	PHE450
F	GLY451
F	HIS491
F	ARG502
F	ASP543
F	ARG568

site_id	AE2
Number of Residues	4
Details	binding site for residue PGE F 1004

Chain	Residue
D	GLY49
F	LYS599
H	LYS394
H	LYS395

site_id	AE3
Number of Residues	8
Details	binding site for residue FLC G 1001

Chain	Residue
G	SER292
G	GLY293
G	ALA323
G	ASN324
G	PHE325
G	THR326
G	ARG357
H	ILE139

site_id	AE4
Number of Residues	9
Details	binding site for residue COA H 1001

Chain	Residue
A	LYS248
B	VAL17
H	LYS480
H	PRO485
H	VAL486
H	ILE489
H	LYS534
H	LYS535
H	LEU538

site_id	AE5
Number of Residues	9
Details	binding site for residue COA H 1002

Chain	Residue
H	TYR44
H	PRO45
H	PRO46
H	TYR85
H	LEU86
H	GLY87
H	ARG90
H	ILE110
H	GLU112

site_id	AE6
Number of Residues	10
Details	binding site for residue FLC H 1003

Chain	Residue
D	ARG588
H	HIS415
H	VAL419
H	PHE450
H	GLY451
H	HIS491
H	ARG502
H	ASP543
H	ARG568
H	HOH1117

site_id	AE7
Number of Residues	5
Details	binding site for residue PGE H 1004

Chain	Residue
H	LYS462
H	GLU466
H	CYS520
H	MET551
H	ASP554

Functional Information from PROSITE/UniProt

site_id	PS00238
Number of Residues	17
Details	OPSIN Visual pigments (opsins) retinal binding site. AGsArSKMNAlrDAgaY

Chain	Residue	Details
B	ALA283-TYR299

site_id	PS01217
Number of Residues	25
Details	SUCCINYL_COA_LIG_3 ATP-citrate lyase / succinyl-CoA ligases family signature 3. GeIalLtAGGGASvfyaDaVvar.GG

Chain	Residue	Details
A	GLY259-GLY283

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)