6HXJ
Structure of ATP citrate lyase from Chlorobium limicola in complex with citrate and coenzyme A.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003878 | molecular_function | ATP citrate synthase activity |
| A | 0004775 | molecular_function | succinate-CoA ligase (ADP-forming) activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0006104 | biological_process | succinyl-CoA metabolic process |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016874 | molecular_function | ligase activity |
| A | 0042709 | cellular_component | succinate-CoA ligase complex |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0003878 | molecular_function | ATP citrate synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006085 | biological_process | acetyl-CoA biosynthetic process |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003878 | molecular_function | ATP citrate synthase activity |
| C | 0004775 | molecular_function | succinate-CoA ligase (ADP-forming) activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006099 | biological_process | tricarboxylic acid cycle |
| C | 0006104 | biological_process | succinyl-CoA metabolic process |
| C | 0016746 | molecular_function | acyltransferase activity |
| C | 0016829 | molecular_function | lyase activity |
| C | 0016874 | molecular_function | ligase activity |
| C | 0042709 | cellular_component | succinate-CoA ligase complex |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0003878 | molecular_function | ATP citrate synthase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006085 | biological_process | acetyl-CoA biosynthetic process |
| D | 0006099 | biological_process | tricarboxylic acid cycle |
| D | 0006629 | biological_process | lipid metabolic process |
| D | 0006633 | biological_process | fatty acid biosynthetic process |
| D | 0016829 | molecular_function | lyase activity |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0003878 | molecular_function | ATP citrate synthase activity |
| E | 0004775 | molecular_function | succinate-CoA ligase (ADP-forming) activity |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006099 | biological_process | tricarboxylic acid cycle |
| E | 0006104 | biological_process | succinyl-CoA metabolic process |
| E | 0016746 | molecular_function | acyltransferase activity |
| E | 0016829 | molecular_function | lyase activity |
| E | 0016874 | molecular_function | ligase activity |
| E | 0042709 | cellular_component | succinate-CoA ligase complex |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0003878 | molecular_function | ATP citrate synthase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0006085 | biological_process | acetyl-CoA biosynthetic process |
| F | 0006099 | biological_process | tricarboxylic acid cycle |
| F | 0006629 | biological_process | lipid metabolic process |
| F | 0006633 | biological_process | fatty acid biosynthetic process |
| F | 0016829 | molecular_function | lyase activity |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
| G | 0000166 | molecular_function | nucleotide binding |
| G | 0003878 | molecular_function | ATP citrate synthase activity |
| G | 0004775 | molecular_function | succinate-CoA ligase (ADP-forming) activity |
| G | 0005524 | molecular_function | ATP binding |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0006099 | biological_process | tricarboxylic acid cycle |
| G | 0006104 | biological_process | succinyl-CoA metabolic process |
| G | 0016746 | molecular_function | acyltransferase activity |
| G | 0016829 | molecular_function | lyase activity |
| G | 0016874 | molecular_function | ligase activity |
| G | 0042709 | cellular_component | succinate-CoA ligase complex |
| G | 0046872 | molecular_function | metal ion binding |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0003878 | molecular_function | ATP citrate synthase activity |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005829 | cellular_component | cytosol |
| H | 0006085 | biological_process | acetyl-CoA biosynthetic process |
| H | 0006099 | biological_process | tricarboxylic acid cycle |
| H | 0006629 | biological_process | lipid metabolic process |
| H | 0006633 | biological_process | fatty acid biosynthetic process |
| H | 0016829 | molecular_function | lyase activity |
| H | 0046872 | molecular_function | metal ion binding |
| H | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue FLC A 1001 |
| Chain | Residue |
| A | SER292 |
| A | GLY293 |
| A | ALA323 |
| A | ASN324 |
| A | PHE325 |
| A | THR326 |
| A | ARG357 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue COA B 1001 |
| Chain | Residue |
| B | VAL486 |
| B | ILE489 |
| B | LYS534 |
| B | LYS535 |
| B | LEU538 |
| B | LYS480 |
| B | PRO485 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue COA B 1002 |
| Chain | Residue |
| B | TYR44 |
| B | PRO45 |
| B | PRO46 |
| B | TYR85 |
| B | LEU86 |
| B | GLY87 |
| B | ARG90 |
| B | ILE110 |
| B | GLU112 |
| B | HOH1125 |
| H | LYS480 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue FLC B 1003 |
| Chain | Residue |
| B | HIS415 |
| B | VAL419 |
| B | PHE450 |
| B | GLY451 |
| B | HIS491 |
| B | ARG502 |
| B | ASP543 |
| B | ARG568 |
| B | HOH1118 |
| F | ARG588 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue PGE B 1004 |
| Chain | Residue |
| B | LYS219 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue TRS B 1005 |
| Chain | Residue |
| B | GLU53 |
| B | HOH1115 |
| D | TYR590 |
| D | HOH1116 |
| D | HOH1118 |
| F | GLU352 |
| F | PRO353 |
| F | ARG356 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue FLC C 1001 |
| Chain | Residue |
| C | SER292 |
| C | GLY293 |
| C | ALA323 |
| C | ASN324 |
| C | PHE325 |
| C | THR326 |
| C | ARG357 |
| D | TRS1004 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue PG4 C 1002 |
| Chain | Residue |
| C | ALA103 |
| C | LYS196 |
| C | HOH1103 |
| C | HOH1105 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue PGE C 1003 |
| Chain | Residue |
| C | ALA2 |
| C | GLN185 |
| C | TYR212 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue COA D 1001 |
| Chain | Residue |
| D | LYS480 |
| D | PRO485 |
| D | VAL486 |
| D | ILE489 |
| D | LYS534 |
| D | LYS535 |
| D | LEU538 |
| E | LYS248 |
| site_id | AD2 |
| Number of Residues | 9 |
| Details | binding site for residue COA D 1002 |
| Chain | Residue |
| D | TYR44 |
| D | PRO45 |
| D | PRO46 |
| D | TYR85 |
| D | LEU86 |
| D | GLY87 |
| D | ARG90 |
| D | ILE110 |
| D | GLU112 |
| site_id | AD3 |
| Number of Residues | 9 |
| Details | binding site for residue FLC D 1003 |
| Chain | Residue |
| D | HIS415 |
| D | VAL419 |
| D | PHE450 |
| D | GLY451 |
| D | HIS491 |
| D | ARG502 |
| D | ASP543 |
| D | ARG568 |
| H | ARG588 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue TRS D 1004 |
| Chain | Residue |
| C | GLY268 |
| C | GLY269 |
| C | FLC1001 |
| D | SER176 |
| D | GLY177 |
| D | GLY178 |
| D | HOH1115 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue PG4 D 1005 |
| Chain | Residue |
| B | LYS394 |
| B | LYS395 |
| D | LYS599 |
| F | GLY49 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue PGE D 1006 |
| Chain | Residue |
| D | LYS313 |
| D | ARG294 |
| D | GLY297 |
| D | TYR299 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue FLC E 1001 |
| Chain | Residue |
| E | SER292 |
| E | GLY293 |
| E | ALA323 |
| E | ASN324 |
| E | PHE325 |
| E | THR326 |
| E | ARG357 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for residue COA F 1001 |
| Chain | Residue |
| F | LYS480 |
| F | PRO485 |
| F | VAL486 |
| F | ILE489 |
| F | LYS534 |
| F | LYS535 |
| F | LEU538 |
| site_id | AD9 |
| Number of Residues | 10 |
| Details | binding site for residue COA F 1002 |
| Chain | Residue |
| F | TYR44 |
| F | PRO45 |
| F | PRO46 |
| F | TYR85 |
| F | LEU86 |
| F | GLY87 |
| F | ARG90 |
| F | ILE110 |
| F | GLU112 |
| F | HOH1106 |
| site_id | AE1 |
| Number of Residues | 9 |
| Details | binding site for residue FLC F 1003 |
| Chain | Residue |
| B | ARG588 |
| F | HIS415 |
| F | VAL419 |
| F | PHE450 |
| F | GLY451 |
| F | HIS491 |
| F | ARG502 |
| F | ASP543 |
| F | ARG568 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue PGE F 1004 |
| Chain | Residue |
| D | GLY49 |
| F | LYS599 |
| H | LYS394 |
| H | LYS395 |
| site_id | AE3 |
| Number of Residues | 8 |
| Details | binding site for residue FLC G 1001 |
| Chain | Residue |
| G | SER292 |
| G | GLY293 |
| G | ALA323 |
| G | ASN324 |
| G | PHE325 |
| G | THR326 |
| G | ARG357 |
| H | ILE139 |
| site_id | AE4 |
| Number of Residues | 9 |
| Details | binding site for residue COA H 1001 |
| Chain | Residue |
| A | LYS248 |
| B | VAL17 |
| H | LYS480 |
| H | PRO485 |
| H | VAL486 |
| H | ILE489 |
| H | LYS534 |
| H | LYS535 |
| H | LEU538 |
| site_id | AE5 |
| Number of Residues | 9 |
| Details | binding site for residue COA H 1002 |
| Chain | Residue |
| H | TYR44 |
| H | PRO45 |
| H | PRO46 |
| H | TYR85 |
| H | LEU86 |
| H | GLY87 |
| H | ARG90 |
| H | ILE110 |
| H | GLU112 |
| site_id | AE6 |
| Number of Residues | 10 |
| Details | binding site for residue FLC H 1003 |
| Chain | Residue |
| D | ARG588 |
| H | HIS415 |
| H | VAL419 |
| H | PHE450 |
| H | GLY451 |
| H | HIS491 |
| H | ARG502 |
| H | ASP543 |
| H | ARG568 |
| H | HOH1117 |
| site_id | AE7 |
| Number of Residues | 5 |
| Details | binding site for residue PGE H 1004 |
| Chain | Residue |
| H | LYS462 |
| H | GLU466 |
| H | CYS520 |
| H | MET551 |
| H | ASP554 |
Functional Information from PROSITE/UniProt
| site_id | PS00238 |
| Number of Residues | 17 |
| Details | OPSIN Visual pigments (opsins) retinal binding site. AGsArSKMNAlrDAgaY |
| Chain | Residue | Details |
| B | ALA283-TYR299 |
| site_id | PS01217 |
| Number of Residues | 25 |
| Details | SUCCINYL_COA_LIG_3 ATP-citrate lyase / succinyl-CoA ligases family signature 3. GeIalLtAGGGASvfyaDaVvar.GG |
| Chain | Residue | Details |
| A | GLY259-GLY283 |
