6HXI
Structure of ATP citrate lyase from Methanothrix soehngenii in complex with citrate and coenzyme A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003878 | molecular_function | ATP citrate synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006085 | biological_process | acetyl-CoA biosynthetic process |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0003878 | molecular_function | ATP citrate synthase activity |
| B | 0004775 | molecular_function | succinate-CoA ligase (ADP-forming) activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006085 | biological_process | acetyl-CoA biosynthetic process |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016874 | molecular_function | ligase activity |
| B | 0043758 | molecular_function | acetate-CoA ligase (ADP-forming) activity |
| B | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0003878 | molecular_function | ATP citrate synthase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006085 | biological_process | acetyl-CoA biosynthetic process |
| C | 0006629 | biological_process | lipid metabolic process |
| C | 0006633 | biological_process | fatty acid biosynthetic process |
| C | 0016746 | molecular_function | acyltransferase activity |
| C | 0016829 | molecular_function | lyase activity |
| C | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0003878 | molecular_function | ATP citrate synthase activity |
| D | 0004775 | molecular_function | succinate-CoA ligase (ADP-forming) activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006085 | biological_process | acetyl-CoA biosynthetic process |
| D | 0006629 | biological_process | lipid metabolic process |
| D | 0006633 | biological_process | fatty acid biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016874 | molecular_function | ligase activity |
| D | 0043758 | molecular_function | acetate-CoA ligase (ADP-forming) activity |
| D | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue FLC A 501 |
| Chain | Residue |
| A | SER306 |
| D | COA701 |
| D | HOH802 |
| A | GLY307 |
| A | ALA343 |
| A | ASN344 |
| A | PHE345 |
| A | THR346 |
| A | ARG377 |
| A | HOH607 |
| D | GLY180 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 502 |
| Chain | Residue |
| A | ASP255 |
| A | THR258 |
| A | ALA260 |
| A | HOH662 |
| site_id | AC3 |
| Number of Residues | 30 |
| Details | binding site for residue COA B 701 |
| Chain | Residue |
| B | PHE87 |
| B | SER89 |
| B | ARG91 |
| B | SER92 |
| B | ILE112 |
| B | GLU114 |
| B | ALA139 |
| B | THR140 |
| B | VAL141 |
| B | GLY179 |
| B | LYS479 |
| B | ASN484 |
| B | ILE485 |
| B | ILE488 |
| B | LYS532 |
| B | LYS533 |
| B | LEU536 |
| B | HOH826 |
| B | HOH832 |
| B | HOH834 |
| B | HOH844 |
| B | HOH847 |
| B | HOH851 |
| B | HOH871 |
| B | HOH877 |
| B | HOH907 |
| C | GLY259 |
| C | GLY307 |
| C | FLC501 |
| C | HOH602 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue PGE B 702 |
| Chain | Residue |
| B | GLY52 |
| B | ILE53 |
| B | MET67 |
| B | TYR68 |
| D | ARG593 |
| D | LEU594 |
| D | GLY595 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue PGE B 703 |
| Chain | Residue |
| B | ILE53 |
| B | MET609 |
| B | HOH857 |
| B | HOH862 |
| B | HOH979 |
| D | LYS394 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue PG4 B 704 |
| Chain | Residue |
| B | LYS592 |
| B | ARG593 |
| B | HOH854 |
| D | GLY52 |
| D | ILE53 |
| D | MET67 |
| D | TYR68 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue ACT B 705 |
| Chain | Residue |
| B | GLY298 |
| B | TYR300 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ACT B 706 |
| Chain | Residue |
| B | HIS415 |
| B | PHE450 |
| B | ARG501 |
| B | ARG580 |
| site_id | AC9 |
| Number of Residues | 13 |
| Details | binding site for residue FLC C 501 |
| Chain | Residue |
| B | GLY180 |
| B | COA701 |
| C | SER306 |
| C | GLY307 |
| C | ALA343 |
| C | ASN344 |
| C | PHE345 |
| C | THR346 |
| C | ARG377 |
| C | HOH601 |
| C | HOH602 |
| C | HOH603 |
| C | HOH604 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue NA C 502 |
| Chain | Residue |
| C | ASP255 |
| C | THR258 |
| C | ALA260 |
| site_id | AD2 |
| Number of Residues | 28 |
| Details | binding site for residue COA D 701 |
| Chain | Residue |
| D | VAL141 |
| D | GLY179 |
| D | LYS479 |
| D | ASN484 |
| D | ILE485 |
| D | ILE488 |
| D | LYS532 |
| D | LYS533 |
| D | LEU536 |
| D | HOH824 |
| D | HOH828 |
| D | HOH837 |
| D | HOH855 |
| D | HOH861 |
| D | HOH868 |
| D | HOH911 |
| A | GLY259 |
| A | GLY307 |
| A | FLC501 |
| A | HOH607 |
| D | PHE87 |
| D | SER89 |
| D | ARG91 |
| D | SER92 |
| D | ILE112 |
| D | GLU114 |
| D | ALA139 |
| D | THR140 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue SIN D 702 |
| Chain | Residue |
| B | HOH862 |
| D | TRP392 |
| D | PHE393 |
| D | LYS394 |
| D | PHE558 |
| D | TYR571 |
| D | ARG593 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue ACT D 703 |
| Chain | Residue |
| D | ARG501 |
| D | ARG580 |
