6HXI
Structure of ATP citrate lyase from Methanothrix soehngenii in complex with citrate and coenzyme A
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0003878 | molecular_function | ATP citrate synthase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006085 | biological_process | acetyl-CoA biosynthetic process |
A | 0006629 | biological_process | lipid metabolic process |
A | 0006633 | biological_process | fatty acid biosynthetic process |
A | 0016746 | molecular_function | acyltransferase activity |
A | 0016829 | molecular_function | lyase activity |
A | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
B | 0003824 | molecular_function | catalytic activity |
B | 0003878 | molecular_function | ATP citrate synthase activity |
B | 0004775 | molecular_function | succinate-CoA ligase (ADP-forming) activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006085 | biological_process | acetyl-CoA biosynthetic process |
B | 0006629 | biological_process | lipid metabolic process |
B | 0006633 | biological_process | fatty acid biosynthetic process |
B | 0016740 | molecular_function | transferase activity |
B | 0016874 | molecular_function | ligase activity |
B | 0043758 | molecular_function | acetate-CoA ligase (ADP-forming) activity |
B | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
C | 0000166 | molecular_function | nucleotide binding |
C | 0003878 | molecular_function | ATP citrate synthase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0006085 | biological_process | acetyl-CoA biosynthetic process |
C | 0006629 | biological_process | lipid metabolic process |
C | 0006633 | biological_process | fatty acid biosynthetic process |
C | 0016746 | molecular_function | acyltransferase activity |
C | 0016829 | molecular_function | lyase activity |
C | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
D | 0003824 | molecular_function | catalytic activity |
D | 0003878 | molecular_function | ATP citrate synthase activity |
D | 0004775 | molecular_function | succinate-CoA ligase (ADP-forming) activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0006085 | biological_process | acetyl-CoA biosynthetic process |
D | 0006629 | biological_process | lipid metabolic process |
D | 0006633 | biological_process | fatty acid biosynthetic process |
D | 0016740 | molecular_function | transferase activity |
D | 0016874 | molecular_function | ligase activity |
D | 0043758 | molecular_function | acetate-CoA ligase (ADP-forming) activity |
D | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 11 |
Details | binding site for residue FLC A 501 |
Chain | Residue |
A | SER306 |
D | COA701 |
D | HOH802 |
A | GLY307 |
A | ALA343 |
A | ASN344 |
A | PHE345 |
A | THR346 |
A | ARG377 |
A | HOH607 |
D | GLY180 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue NA A 502 |
Chain | Residue |
A | ASP255 |
A | THR258 |
A | ALA260 |
A | HOH662 |
site_id | AC3 |
Number of Residues | 30 |
Details | binding site for residue COA B 701 |
Chain | Residue |
B | PHE87 |
B | SER89 |
B | ARG91 |
B | SER92 |
B | ILE112 |
B | GLU114 |
B | ALA139 |
B | THR140 |
B | VAL141 |
B | GLY179 |
B | LYS479 |
B | ASN484 |
B | ILE485 |
B | ILE488 |
B | LYS532 |
B | LYS533 |
B | LEU536 |
B | HOH826 |
B | HOH832 |
B | HOH834 |
B | HOH844 |
B | HOH847 |
B | HOH851 |
B | HOH871 |
B | HOH877 |
B | HOH907 |
C | GLY259 |
C | GLY307 |
C | FLC501 |
C | HOH602 |
site_id | AC4 |
Number of Residues | 7 |
Details | binding site for residue PGE B 702 |
Chain | Residue |
B | GLY52 |
B | ILE53 |
B | MET67 |
B | TYR68 |
D | ARG593 |
D | LEU594 |
D | GLY595 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue PGE B 703 |
Chain | Residue |
B | ILE53 |
B | MET609 |
B | HOH857 |
B | HOH862 |
B | HOH979 |
D | LYS394 |
site_id | AC6 |
Number of Residues | 7 |
Details | binding site for residue PG4 B 704 |
Chain | Residue |
B | LYS592 |
B | ARG593 |
B | HOH854 |
D | GLY52 |
D | ILE53 |
D | MET67 |
D | TYR68 |
site_id | AC7 |
Number of Residues | 2 |
Details | binding site for residue ACT B 705 |
Chain | Residue |
B | GLY298 |
B | TYR300 |
site_id | AC8 |
Number of Residues | 4 |
Details | binding site for residue ACT B 706 |
Chain | Residue |
B | HIS415 |
B | PHE450 |
B | ARG501 |
B | ARG580 |
site_id | AC9 |
Number of Residues | 13 |
Details | binding site for residue FLC C 501 |
Chain | Residue |
B | GLY180 |
B | COA701 |
C | SER306 |
C | GLY307 |
C | ALA343 |
C | ASN344 |
C | PHE345 |
C | THR346 |
C | ARG377 |
C | HOH601 |
C | HOH602 |
C | HOH603 |
C | HOH604 |
site_id | AD1 |
Number of Residues | 3 |
Details | binding site for residue NA C 502 |
Chain | Residue |
C | ASP255 |
C | THR258 |
C | ALA260 |
site_id | AD2 |
Number of Residues | 28 |
Details | binding site for residue COA D 701 |
Chain | Residue |
D | VAL141 |
D | GLY179 |
D | LYS479 |
D | ASN484 |
D | ILE485 |
D | ILE488 |
D | LYS532 |
D | LYS533 |
D | LEU536 |
D | HOH824 |
D | HOH828 |
D | HOH837 |
D | HOH855 |
D | HOH861 |
D | HOH868 |
D | HOH911 |
A | GLY259 |
A | GLY307 |
A | FLC501 |
A | HOH607 |
D | PHE87 |
D | SER89 |
D | ARG91 |
D | SER92 |
D | ILE112 |
D | GLU114 |
D | ALA139 |
D | THR140 |
site_id | AD3 |
Number of Residues | 7 |
Details | binding site for residue SIN D 702 |
Chain | Residue |
B | HOH862 |
D | TRP392 |
D | PHE393 |
D | LYS394 |
D | PHE558 |
D | TYR571 |
D | ARG593 |
site_id | AD4 |
Number of Residues | 2 |
Details | binding site for residue ACT D 703 |
Chain | Residue |
D | ARG501 |
D | ARG580 |