6HX7
Crystal structure of human R180T variant of ORNITHINE AMINOTRANSFERASE at 1.8 Angstrom
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004587 | molecular_function | ornithine aminotransferase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0007601 | biological_process | visual perception |
| A | 0008483 | molecular_function | transaminase activity |
| A | 0010121 | biological_process | arginine catabolic process to proline via ornithine |
| A | 0019544 | biological_process | arginine catabolic process to glutamate |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0055129 | biological_process | L-proline biosynthetic process |
| B | 0004587 | molecular_function | ornithine aminotransferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0007601 | biological_process | visual perception |
| B | 0008483 | molecular_function | transaminase activity |
| B | 0010121 | biological_process | arginine catabolic process to proline via ornithine |
| B | 0019544 | biological_process | arginine catabolic process to glutamate |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0055129 | biological_process | L-proline biosynthetic process |
| C | 0004587 | molecular_function | ornithine aminotransferase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005759 | cellular_component | mitochondrial matrix |
| C | 0007601 | biological_process | visual perception |
| C | 0008483 | molecular_function | transaminase activity |
| C | 0010121 | biological_process | arginine catabolic process to proline via ornithine |
| C | 0019544 | biological_process | arginine catabolic process to glutamate |
| C | 0030170 | molecular_function | pyridoxal phosphate binding |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0055129 | biological_process | L-proline biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue PLP A 501 |
| Chain | Residue |
| A | GLY142 |
| A | HOH631 |
| A | HOH705 |
| A | HOH724 |
| A | HOH761 |
| A | HOH816 |
| A | VAL143 |
| A | PHE177 |
| A | TRP178 |
| A | GLU230 |
| A | ASP263 |
| A | GLN266 |
| A | LYS292 |
| A | THR322 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue PLP B 501 |
| Chain | Residue |
| B | GLY142 |
| B | VAL143 |
| B | PHE177 |
| B | TRP178 |
| B | ASP263 |
| B | ILE265 |
| B | GLN266 |
| B | LYS292 |
| B | THR322 |
| B | HOH631 |
| B | HOH646 |
| B | HOH717 |
| B | HOH729 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | binding site for residue PLP C 501 |
| Chain | Residue |
| C | GLY142 |
| C | VAL143 |
| C | PHE177 |
| C | TRP178 |
| C | GLU230 |
| C | ASP263 |
| C | ILE265 |
| C | GLN266 |
| C | LYS292 |
| C | THR322 |
| C | HOH645 |
| C | HOH707 |
| C | HOH713 |
| C | HOH737 |
| C | HOH796 |
| C | HOH806 |
Functional Information from PROSITE/UniProt
| site_id | PS00600 |
| Number of Residues | 38 |
| Details | AA_TRANSFER_CLASS_3 Aminotransferases class-III pyridoxal-phosphate attachment site. FIaDEIqt.GLaRtGrwlavdyenvrp....DIVllGKalsGG |
| Chain | Residue | Details |
| A | PHE260-GLY297 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 15 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P29758 |
| Chain | Residue | Details |
| A | LYS49 | |
| B | LYS421 | |
| C | LYS49 | |
| C | LYS66 | |
| C | LYS386 | |
| C | LYS392 | |
| C | LYS421 | |
| A | LYS66 | |
| A | LYS386 | |
| A | LYS392 | |
| A | LYS421 | |
| B | LYS49 | |
| B | LYS66 | |
| B | LYS386 | |
| B | LYS392 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P29758 |
| Chain | Residue | Details |
| A | LYS102 | |
| B | LYS102 | |
| C | LYS102 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P29758 |
| Chain | Residue | Details |
| A | LYS107 | |
| A | LYS362 | |
| A | LYS405 | |
| B | LYS107 | |
| B | LYS362 | |
| B | LYS405 | |
| C | LYS107 | |
| C | LYS362 | |
| C | LYS405 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:3754226 |
| Chain | Residue | Details |
| A | LYS292 | |
| B | LYS292 | |
| C | LYS292 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 929 |
| Chain | Residue | Details |
| A | PHE177 | steric role |
| A | ASP263 | electrostatic stabiliser |
| A | LYS292 | covalent catalysis, proton shuttle (general acid/base) |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 929 |
| Chain | Residue | Details |
| B | PHE177 | steric role |
| B | ASP263 | electrostatic stabiliser |
| B | LYS292 | covalent catalysis, proton shuttle (general acid/base) |
| site_id | MCSA3 |
| Number of Residues | 3 |
| Details | M-CSA 929 |
| Chain | Residue | Details |
| C | PHE177 | steric role |
| C | ASP263 | electrostatic stabiliser |
| C | LYS292 | covalent catalysis, proton shuttle (general acid/base) |
