6HVD
Human SLK bound to a maleimide inhibitor
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 401 |
| Chain | Residue |
| A | HIS147 |
| A | ASP209 |
| A | PRO211 |
| A | EDO402 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 402 |
| Chain | Residue |
| A | EDO401 |
| A | HOH539 |
| A | HIS147 |
| A | PRO211 |
| A | TYR214 |
| A | THR282 |
| A | THR283 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 403 |
| Chain | Residue |
| A | ARG210 |
| A | ARG210 |
| A | HOH584 |
| A | HOH584 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | binding site for residue GUQ A 404 |
| Chain | Residue |
| A | LEU40 |
| A | GLY41 |
| A | ASP42 |
| A | VAL48 |
| A | ALA61 |
| A | LYS63 |
| A | ILE108 |
| A | GLU109 |
| A | PHE110 |
| A | CYS111 |
| A | GLY159 |
| A | LEU162 |
| A | ALA172 |
| A | HOH568 |
| A | HOH569 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 A 405 |
| Chain | Residue |
| A | SER263 |
| A | SER263 |
| A | LYS266 |
| A | LYS266 |
| A | HOH502 |
| A | HOH502 |
| A | HOH508 |
| A | HOH508 |
| A | HOH523 |
| A | HOH523 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 406 |
| Chain | Residue |
| A | THR25 |
| A | ASP96 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGDGAFGKVYkAqnketsvl..........AAAK |
| Chain | Residue | Details |
| A | LEU40-LYS63 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKagNILF |
| Chain | Residue | Details |
| A | ILE151-PHE163 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
