6HV2
MMP-13 in complex with the peptide IMISF
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 301 |
| Chain | Residue |
| A | HIS222 |
| A | HIS226 |
| A | HIS232 |
| B | ILE163 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 302 |
| Chain | Residue |
| A | HIS172 |
| A | ASP174 |
| A | HIS187 |
| A | HIS200 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 303 |
| Chain | Residue |
| A | GLY180 |
| A | SER182 |
| A | LEU184 |
| A | ASP202 |
| A | GLU205 |
| A | ASP179 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue CA A 304 |
| Chain | Residue |
| A | TYR104 |
| A | ASP162 |
| A | ASN194 |
| A | GLY196 |
| A | ASP198 |
| A | HOH421 |
| A | HOH431 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue CA A 305 |
| Chain | Residue |
| A | ASP128 |
| A | ASP203 |
| A | GLU205 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 306 |
| Chain | Residue |
| A | ALA188 |
| A | HIS226 |
| A | HIS232 |
| A | HIS232 |
| A | LYS234 |
| A | HOH472 |
| B | ILE163 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEFGHSL |
| Chain | Residue | Details |
| A | VAL219-LEU228 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000305|PubMed:23913860 |
| Chain | Residue | Details |
| A | GLU223 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305 |
| Chain | Residue | Details |
| A | ASP128 | |
| A | ASP202 | |
| A | ASP203 | |
| A | GLU205 | |
| A | ASP162 | |
| A | ASP179 | |
| A | GLY180 | |
| A | SER182 | |
| A | LEU184 | |
| A | ASN194 | |
| A | GLY196 | |
| A | ASP198 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860 |
| Chain | Residue | Details |
| A | HIS172 | |
| A | ASP174 | |
| A | HIS187 | |
| A | HIS200 | |
| A | HIS222 | |
| A | HIS226 | |
| A | HIS232 | |
| A | MET240 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:8576151 |
| Chain | Residue | Details |
| A | ASN117 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN152 |
