Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6HSV

Engineered higher-order assembly of Cholera Toxin B subunits via the addition of C-terminal parallel coiled-coiled domains

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005534	molecular_function	galactose binding
A	0005576	cellular_component	extracellular region
A	0016020	cellular_component	membrane
A	0020002	cellular_component	host cell plasma membrane
A	0033644	cellular_component	host cell membrane
A	0035821	biological_process	modulation of process of another organism
A	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
A	0042597	cellular_component	periplasmic space
A	0046812	molecular_function	host cell surface binding
A	0090729	molecular_function	toxin activity
A	1902494	cellular_component	catalytic complex
B	0005515	molecular_function	protein binding
B	0005534	molecular_function	galactose binding
B	0005576	cellular_component	extracellular region
B	0016020	cellular_component	membrane
B	0020002	cellular_component	host cell plasma membrane
B	0033644	cellular_component	host cell membrane
B	0035821	biological_process	modulation of process of another organism
B	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
B	0042597	cellular_component	periplasmic space
B	0046812	molecular_function	host cell surface binding
B	0090729	molecular_function	toxin activity
B	1902494	cellular_component	catalytic complex
C	0005515	molecular_function	protein binding
C	0005534	molecular_function	galactose binding
C	0005576	cellular_component	extracellular region
C	0016020	cellular_component	membrane
C	0020002	cellular_component	host cell plasma membrane
C	0033644	cellular_component	host cell membrane
C	0035821	biological_process	modulation of process of another organism
C	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
C	0042597	cellular_component	periplasmic space
C	0046812	molecular_function	host cell surface binding
C	0090729	molecular_function	toxin activity
C	1902494	cellular_component	catalytic complex
D	0005515	molecular_function	protein binding
D	0005534	molecular_function	galactose binding
D	0005576	cellular_component	extracellular region
D	0016020	cellular_component	membrane
D	0020002	cellular_component	host cell plasma membrane
D	0033644	cellular_component	host cell membrane
D	0035821	biological_process	modulation of process of another organism
D	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
D	0042597	cellular_component	periplasmic space
D	0046812	molecular_function	host cell surface binding
D	0090729	molecular_function	toxin activity
D	1902494	cellular_component	catalytic complex
E	0005515	molecular_function	protein binding
E	0005534	molecular_function	galactose binding
E	0005576	cellular_component	extracellular region
E	0016020	cellular_component	membrane
E	0020002	cellular_component	host cell plasma membrane
E	0033644	cellular_component	host cell membrane
E	0035821	biological_process	modulation of process of another organism
E	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
E	0042597	cellular_component	periplasmic space
E	0046812	molecular_function	host cell surface binding
E	0090729	molecular_function	toxin activity
E	1902494	cellular_component	catalytic complex
F	0005515	molecular_function	protein binding
F	0005534	molecular_function	galactose binding
F	0005576	cellular_component	extracellular region
F	0016020	cellular_component	membrane
F	0020002	cellular_component	host cell plasma membrane
F	0033644	cellular_component	host cell membrane
F	0035821	biological_process	modulation of process of another organism
F	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
F	0042597	cellular_component	periplasmic space
F	0046812	molecular_function	host cell surface binding
F	0090729	molecular_function	toxin activity
F	1902494	cellular_component	catalytic complex
G	0005515	molecular_function	protein binding
G	0005534	molecular_function	galactose binding
G	0005576	cellular_component	extracellular region
G	0016020	cellular_component	membrane
G	0020002	cellular_component	host cell plasma membrane
G	0033644	cellular_component	host cell membrane
G	0035821	biological_process	modulation of process of another organism
G	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
G	0042597	cellular_component	periplasmic space
G	0046812	molecular_function	host cell surface binding
G	0090729	molecular_function	toxin activity
G	1902494	cellular_component	catalytic complex
H	0005515	molecular_function	protein binding
H	0005534	molecular_function	galactose binding
H	0005576	cellular_component	extracellular region
H	0016020	cellular_component	membrane
H	0020002	cellular_component	host cell plasma membrane
H	0033644	cellular_component	host cell membrane
H	0035821	biological_process	modulation of process of another organism
H	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
H	0042597	cellular_component	periplasmic space
H	0046812	molecular_function	host cell surface binding
H	0090729	molecular_function	toxin activity
H	1902494	cellular_component	catalytic complex
I	0005515	molecular_function	protein binding
I	0005534	molecular_function	galactose binding
I	0005576	cellular_component	extracellular region
I	0016020	cellular_component	membrane
I	0020002	cellular_component	host cell plasma membrane
I	0033644	cellular_component	host cell membrane
I	0035821	biological_process	modulation of process of another organism
I	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
I	0042597	cellular_component	periplasmic space
I	0046812	molecular_function	host cell surface binding
I	0090729	molecular_function	toxin activity
I	1902494	cellular_component	catalytic complex
J	0005515	molecular_function	protein binding
J	0005534	molecular_function	galactose binding
J	0005576	cellular_component	extracellular region
J	0016020	cellular_component	membrane
J	0020002	cellular_component	host cell plasma membrane
J	0033644	cellular_component	host cell membrane
J	0035821	biological_process	modulation of process of another organism
J	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
J	0042597	cellular_component	periplasmic space
J	0046812	molecular_function	host cell surface binding
J	0090729	molecular_function	toxin activity
J	1902494	cellular_component	catalytic complex
K	0005515	molecular_function	protein binding
K	0005534	molecular_function	galactose binding
K	0005576	cellular_component	extracellular region
K	0016020	cellular_component	membrane
K	0020002	cellular_component	host cell plasma membrane
K	0033644	cellular_component	host cell membrane
K	0035821	biological_process	modulation of process of another organism
K	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
K	0042597	cellular_component	periplasmic space
K	0046812	molecular_function	host cell surface binding
K	0090729	molecular_function	toxin activity
K	1902494	cellular_component	catalytic complex
L	0005515	molecular_function	protein binding
L	0005534	molecular_function	galactose binding
L	0005576	cellular_component	extracellular region
L	0016020	cellular_component	membrane
L	0020002	cellular_component	host cell plasma membrane
L	0033644	cellular_component	host cell membrane
L	0035821	biological_process	modulation of process of another organism
L	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
L	0042597	cellular_component	periplasmic space
L	0046812	molecular_function	host cell surface binding
L	0090729	molecular_function	toxin activity
L	1902494	cellular_component	catalytic complex
M	0005515	molecular_function	protein binding
M	0005534	molecular_function	galactose binding
M	0005576	cellular_component	extracellular region
M	0016020	cellular_component	membrane
M	0020002	cellular_component	host cell plasma membrane
M	0033644	cellular_component	host cell membrane
M	0035821	biological_process	modulation of process of another organism
M	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
M	0042597	cellular_component	periplasmic space
M	0046812	molecular_function	host cell surface binding
M	0090729	molecular_function	toxin activity
M	1902494	cellular_component	catalytic complex
N	0005515	molecular_function	protein binding
N	0005534	molecular_function	galactose binding
N	0005576	cellular_component	extracellular region
N	0016020	cellular_component	membrane
N	0020002	cellular_component	host cell plasma membrane
N	0033644	cellular_component	host cell membrane
N	0035821	biological_process	modulation of process of another organism
N	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
N	0042597	cellular_component	periplasmic space
N	0046812	molecular_function	host cell surface binding
N	0090729	molecular_function	toxin activity
N	1902494	cellular_component	catalytic complex
O	0005515	molecular_function	protein binding
O	0005534	molecular_function	galactose binding
O	0005576	cellular_component	extracellular region
O	0016020	cellular_component	membrane
O	0020002	cellular_component	host cell plasma membrane
O	0033644	cellular_component	host cell membrane
O	0035821	biological_process	modulation of process of another organism
O	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
O	0042597	cellular_component	periplasmic space
O	0046812	molecular_function	host cell surface binding
O	0090729	molecular_function	toxin activity
O	1902494	cellular_component	catalytic complex
P	0005515	molecular_function	protein binding
P	0005534	molecular_function	galactose binding
P	0005576	cellular_component	extracellular region
P	0016020	cellular_component	membrane
P	0020002	cellular_component	host cell plasma membrane
P	0033644	cellular_component	host cell membrane
P	0035821	biological_process	modulation of process of another organism
P	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
P	0042597	cellular_component	periplasmic space
P	0046812	molecular_function	host cell surface binding
P	0090729	molecular_function	toxin activity
P	1902494	cellular_component	catalytic complex
Q	0005515	molecular_function	protein binding
Q	0005534	molecular_function	galactose binding
Q	0005576	cellular_component	extracellular region
Q	0016020	cellular_component	membrane
Q	0020002	cellular_component	host cell plasma membrane
Q	0033644	cellular_component	host cell membrane
Q	0035821	biological_process	modulation of process of another organism
Q	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
Q	0042597	cellular_component	periplasmic space
Q	0046812	molecular_function	host cell surface binding
Q	0090729	molecular_function	toxin activity
Q	1902494	cellular_component	catalytic complex
R	0005515	molecular_function	protein binding
R	0005534	molecular_function	galactose binding
R	0005576	cellular_component	extracellular region
R	0016020	cellular_component	membrane
R	0020002	cellular_component	host cell plasma membrane
R	0033644	cellular_component	host cell membrane
R	0035821	biological_process	modulation of process of another organism
R	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
R	0042597	cellular_component	periplasmic space
R	0046812	molecular_function	host cell surface binding
R	0090729	molecular_function	toxin activity
R	1902494	cellular_component	catalytic complex
S	0005515	molecular_function	protein binding
S	0005534	molecular_function	galactose binding
S	0005576	cellular_component	extracellular region
S	0016020	cellular_component	membrane
S	0020002	cellular_component	host cell plasma membrane
S	0033644	cellular_component	host cell membrane
S	0035821	biological_process	modulation of process of another organism
S	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
S	0042597	cellular_component	periplasmic space
S	0046812	molecular_function	host cell surface binding
S	0090729	molecular_function	toxin activity
S	1902494	cellular_component	catalytic complex
T	0005515	molecular_function	protein binding
T	0005534	molecular_function	galactose binding
T	0005576	cellular_component	extracellular region
T	0016020	cellular_component	membrane
T	0020002	cellular_component	host cell plasma membrane
T	0033644	cellular_component	host cell membrane
T	0035821	biological_process	modulation of process of another organism
T	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
T	0042597	cellular_component	periplasmic space
T	0046812	molecular_function	host cell surface binding
T	0090729	molecular_function	toxin activity
T	1902494	cellular_component	catalytic complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue PO4 A 201

Chain	Residue
A	HIS13
A	ASN14

site_id	AC2
Number of Residues	5
Details	binding site for residue MPD A 202

Chain	Residue
A	ALA46
A	ILE47
A	PRO93
A	HIS94
E	GLN3

site_id	AC3
Number of Residues	6
Details	binding site for residue MPD A 203

Chain	Residue
A	GLU79
A	HOH313
E	THR78
E	ASN103
A	TYR76
A	LEU77

site_id	AC4
Number of Residues	3
Details	binding site for residue MPD B 201

Chain	Residue
A	THR78
B	TYR76
B	LEU77

site_id	AC5
Number of Residues	4
Details	binding site for residue MPD B 202

Chain	Residue
B	THR78
C	TYR76
C	LEU77
C	GLU79

site_id	AC6
Number of Residues	4
Details	binding site for residue PO4 D 201

Chain	Residue
D	TYR12
D	HIS13
D	ASN14
D	LYS34

site_id	AC7
Number of Residues	3
Details	binding site for residue MPD D 202

Chain	Residue
C	THR78
D	LEU77
D	GLU79

site_id	AC8
Number of Residues	3
Details	binding site for residue MPD D 203

Chain	Residue
D	ASN103
E	LEU77
E	GLU79

site_id	AC9
Number of Residues	5
Details	binding site for residue PO4 F 201

Chain	Residue
F	HIS13
F	ASN14
F	HOH311
Q	THR1
R	ARG35

site_id	AD1
Number of Residues	3
Details	binding site for residue MPD G 201

Chain	Residue
G	ALA80
G	HOH316
H	LEU77

site_id	AD2
Number of Residues	5
Details	binding site for residue MPD G 202

Chain	Residue
F	ASN103
G	TYR76
G	LEU77
G	GLU79
G	HOH301

site_id	AD3
Number of Residues	4
Details	binding site for residue MPD H 201

Chain	Residue
H	ALA80
H	ASN103
H	HOH301
I	LEU77

site_id	AD4
Number of Residues	7
Details	binding site for residue MPD H 202

Chain	Residue
H	TYR18
H	ALA46
H	ILE47
H	PHE48
H	PRO93
H	HIS94
O	GLN3

site_id	AD5
Number of Residues	5
Details	binding site for residue MPD H 203

Chain	Residue
H	THR1
H	HOH323
I	ARG35
S	HIS13
S	ASN14

site_id	AD6
Number of Residues	2
Details	binding site for residue PO4 I 201

Chain	Residue
I	HIS13
I	ASN14

site_id	AD7
Number of Residues	6
Details	binding site for residue MPD J 201

Chain	Residue
F	LEU77
F	HOH305
J	ALA80
J	LYS81
J	ASN103
J	HOH329

site_id	AD8
Number of Residues	4
Details	binding site for residue MPD J 202

Chain	Residue
I	THR78
J	TYR76
J	LEU77
J	GLU79

site_id	AD9
Number of Residues	5
Details	binding site for residue MPD L 201

Chain	Residue
K	ASN103
L	TYR76
L	LEU77
L	GLU79
L	HOH303

site_id	AE1
Number of Residues	7
Details	binding site for residue MPD M 201

Chain	Residue
L	THR78
L	GLU79
L	ASN103
M	TYR76
M	LEU77
M	GLU79
M	HOH303

site_id	AE2
Number of Residues	3
Details	binding site for residue MPD N 201

Chain	Residue
M	ALA80
N	LEU77
N	HOH302

site_id	AE3
Number of Residues	3
Details	binding site for residue MPD O 201

Chain	Residue
O	LEU77
O	GLU79
O	HOH301

site_id	AE4
Number of Residues	4
Details	binding site for residue MPD O 202

Chain	Residue
K	HOH203
O	ALA80
O	LYS81
O	ASN103

site_id	AE5
Number of Residues	4
Details	binding site for residue PO4 P 201

Chain	Residue
A	ARG35
E	THR1
P	THR1
Q	ARG35

site_id	AE6
Number of Residues	4
Details	binding site for residue MPD P 202

Chain	Residue
P	HOH303
Q	LEU77
P	THR78
P	ASN103

site_id	AE7
Number of Residues	3
Details	binding site for residue MPD P 203

Chain	Residue
P	LEU77
P	HOH304
T	THR78

site_id	AE8
Number of Residues	3
Details	binding site for residue PO4 Q 201

Chain	Residue
Q	HIS13
Q	ASN14
Q	HOH308

site_id	AE9
Number of Residues	3
Details	binding site for residue MPD Q 202

Chain	Residue
Q	ILE47
Q	PRO93
Q	HIS94

site_id	AF1
Number of Residues	3
Details	binding site for residue MPD R 201

Chain	Residue
R	THR78
R	ASN103
R	HOH306

site_id	AF2
Number of Residues	2
Details	binding site for residue MPD R 202

Chain	Residue
Q	THR78
R	HOH301

site_id	AF3
Number of Residues	6
Details	binding site for residue MPD R 203

Chain	Residue
R	TYR18
R	ALA46
R	ILE47
R	PHE48
R	PRO93
R	HIS94

site_id	AF4
Number of Residues	4
Details	binding site for residue MPD S 201

Chain	Residue
S	ALA46
S	ILE47
S	PRO93
S	HIS94

site_id	AF5
Number of Residues	6
Details	binding site for residue MPD S 202

Chain	Residue
S	GLU11
S	TYR12
T	GLY33
T	LYS34
T	ARG35
T	ASN90

site_id	AF6
Number of Residues	2
Details	binding site for residue MPD T 201

Chain	Residue
T	LEU77
T	HOH315

site_id	AF7
Number of Residues	6
Details	binding site for residue CL T 202

Chain	Residue
S	GLN61
S	TRP88
T	HIS13
T	ASN14
T	GLY33
T	HOH354

site_id	AF8
Number of Residues	16
Details	binding site for Di-peptide GLN N 16 and ASN N 89

Chain	Residue
A	THR1
A	GLN3
A	ASP7
A	GLU11
B	THR92
N	ASN14
N	THR15
N	ILE17
N	TYR18
N	LEU85
N	CYS86
N	VAL87
N	TRP88
N	ASN90
N	LYS91
N	HIS94

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)