6HSU
The crystal structure of type II Dehydroquinase from Psychromonas ingrahamii 37, crystal form 2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0009423 | biological_process | chorismate biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| B | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0009423 | biological_process | chorismate biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| C | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| C | 0009423 | biological_process | chorismate biosynthetic process |
| C | 0016829 | molecular_function | lyase activity |
| D | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| D | 0009423 | biological_process | chorismate biosynthetic process |
| D | 0016829 | molecular_function | lyase activity |
| E | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| E | 0008652 | biological_process | amino acid biosynthetic process |
| E | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| E | 0009423 | biological_process | chorismate biosynthetic process |
| E | 0016829 | molecular_function | lyase activity |
| F | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| F | 0008652 | biological_process | amino acid biosynthetic process |
| F | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| F | 0009423 | biological_process | chorismate biosynthetic process |
| F | 0016829 | molecular_function | lyase activity |
| G | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| G | 0008652 | biological_process | amino acid biosynthetic process |
| G | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| G | 0009423 | biological_process | chorismate biosynthetic process |
| G | 0016829 | molecular_function | lyase activity |
| H | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| H | 0008652 | biological_process | amino acid biosynthetic process |
| H | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| H | 0009423 | biological_process | chorismate biosynthetic process |
| H | 0016829 | molecular_function | lyase activity |
| I | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| I | 0008652 | biological_process | amino acid biosynthetic process |
| I | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| I | 0009423 | biological_process | chorismate biosynthetic process |
| I | 0016829 | molecular_function | lyase activity |
| J | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| J | 0008652 | biological_process | amino acid biosynthetic process |
| J | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| J | 0009423 | biological_process | chorismate biosynthetic process |
| J | 0016829 | molecular_function | lyase activity |
| K | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| K | 0008652 | biological_process | amino acid biosynthetic process |
| K | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| K | 0009423 | biological_process | chorismate biosynthetic process |
| K | 0016829 | molecular_function | lyase activity |
| L | 0003855 | molecular_function | 3-dehydroquinate dehydratase activity |
| L | 0008652 | biological_process | amino acid biosynthetic process |
| L | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| L | 0009423 | biological_process | chorismate biosynthetic process |
| L | 0016829 | molecular_function | lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue TLA A 201 |
| Chain | Residue |
| A | ASN77 |
| A | ALA79 |
| A | HIS83 |
| A | HIS103 |
| A | LEU104 |
| A | SER105 |
| A | ARG110 |
| A | ARG114 |
| A | HOH330 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue TLA B 201 |
| Chain | Residue |
| B | ASN77 |
| B | ALA79 |
| B | ALA80 |
| B | HIS83 |
| B | HIS103 |
| B | LEU104 |
| B | SER105 |
| B | ARG114 |
| B | HOH315 |
| B | HOH319 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 202 |
| Chain | Residue |
| B | ASP40 |
| B | GLU41 |
| B | LEU44 |
| B | HOH308 |
| B | HOH333 |
| K | HIS0 |
| K | ASN46 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue TLA C 201 |
| Chain | Residue |
| C | ASN77 |
| C | ALA79 |
| C | ALA80 |
| C | HIS83 |
| C | HIS103 |
| C | LEU104 |
| C | SER105 |
| C | ARG114 |
| C | HOH320 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | binding site for residue TLA D 201 |
| Chain | Residue |
| D | ASN77 |
| D | ALA79 |
| D | ALA80 |
| D | THR82 |
| D | HIS83 |
| D | HIS103 |
| D | LEU104 |
| D | SER105 |
| D | ARG114 |
| D | HOH336 |
| D | HOH350 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue TLA E 201 |
| Chain | Residue |
| E | ASN77 |
| E | ALA79 |
| E | ALA80 |
| E | HIS83 |
| E | HIS103 |
| E | LEU104 |
| E | SER105 |
| E | ARG110 |
| E | ARG114 |
| E | HOH325 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | binding site for residue TLA F 201 |
| Chain | Residue |
| F | ASN77 |
| F | ALA79 |
| F | ALA80 |
| F | HIS83 |
| F | HIS103 |
| F | LEU104 |
| F | SER105 |
| F | VAL107 |
| F | ARG114 |
| F | HOH312 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue TLA G 201 |
| Chain | Residue |
| G | ASN77 |
| G | ALA79 |
| G | ALA80 |
| G | HIS83 |
| G | HIS103 |
| G | LEU104 |
| G | SER105 |
| G | VAL107 |
| G | ARG114 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | binding site for residue TLA H 201 |
| Chain | Residue |
| H | ASN77 |
| H | ALA79 |
| H | ALA80 |
| H | HIS83 |
| H | HIS103 |
| H | LEU104 |
| H | SER105 |
| H | ARG114 |
| H | HOH336 |
| site_id | AD1 |
| Number of Residues | 10 |
| Details | binding site for residue TLA I 201 |
| Chain | Residue |
| I | ASN77 |
| I | ALA79 |
| I | ALA80 |
| I | HIS83 |
| I | HIS103 |
| I | LEU104 |
| I | SER105 |
| I | VAL107 |
| I | ARG114 |
| I | HOH319 |
| site_id | AD2 |
| Number of Residues | 11 |
| Details | binding site for residue TLA J 201 |
| Chain | Residue |
| J | HIS103 |
| J | LEU104 |
| J | SER105 |
| J | ARG114 |
| J | HOH330 |
| J | HOH337 |
| J | ASN77 |
| J | ALA79 |
| J | ALA80 |
| J | THR82 |
| J | HIS83 |
| site_id | AD3 |
| Number of Residues | 9 |
| Details | binding site for residue TLA K 201 |
| Chain | Residue |
| K | ASN77 |
| K | ALA79 |
| K | ALA80 |
| K | HIS83 |
| K | HIS103 |
| K | LEU104 |
| K | SER105 |
| K | VAL107 |
| K | ARG114 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue MPO K 202 |
| Chain | Residue |
| K | GLN3 |
| K | GLU69 |
| K | LYS70 |
| K | ASP72 |
| site_id | AD5 |
| Number of Residues | 10 |
| Details | binding site for residue TLA L 201 |
| Chain | Residue |
| L | ASN77 |
| L | ALA79 |
| L | ALA80 |
| L | HIS83 |
| L | HIS103 |
| L | LEU104 |
| L | SER105 |
| L | VAL107 |
| L | ARG114 |
| L | HOH340 |
Functional Information from PROSITE/UniProt
| site_id | PS01029 |
| Number of Residues | 18 |
| Details | DEHYDROQUINASE_II Dehydroquinase class II signature. LNGPNLnlLGqREpevYG |
| Chain | Residue | Details |
| A | LEU10-GLY27 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00169 |
| Chain | Residue | Details |
| A | TYR26 | |
| J | TYR26 | |
| K | TYR26 | |
| L | TYR26 | |
| B | TYR26 | |
| C | TYR26 | |
| D | TYR26 | |
| E | TYR26 | |
| F | TYR26 | |
| G | TYR26 | |
| H | TYR26 | |
| I | TYR26 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_00169 |
| Chain | Residue | Details |
| A | HIS103 | |
| J | HIS103 | |
| K | HIS103 | |
| L | HIS103 | |
| B | HIS103 | |
| C | HIS103 | |
| D | HIS103 | |
| E | HIS103 | |
| F | HIS103 | |
| G | HIS103 | |
| H | HIS103 | |
| I | HIS103 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 60 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00169 |
| Chain | Residue | Details |
| A | ASN77 | |
| B | ARG114 | |
| C | ASN77 | |
| C | HIS83 | |
| C | ASP90 | |
| C | LEU104 | |
| C | ARG114 | |
| D | ASN77 | |
| D | HIS83 | |
| D | ASP90 | |
| D | LEU104 | |
| A | HIS83 | |
| D | ARG114 | |
| E | ASN77 | |
| E | HIS83 | |
| E | ASP90 | |
| E | LEU104 | |
| E | ARG114 | |
| F | ASN77 | |
| F | HIS83 | |
| F | ASP90 | |
| F | LEU104 | |
| A | ASP90 | |
| F | ARG114 | |
| G | ASN77 | |
| G | HIS83 | |
| G | ASP90 | |
| G | LEU104 | |
| G | ARG114 | |
| H | ASN77 | |
| H | HIS83 | |
| H | ASP90 | |
| H | LEU104 | |
| A | LEU104 | |
| H | ARG114 | |
| I | ASN77 | |
| I | HIS83 | |
| I | ASP90 | |
| I | LEU104 | |
| I | ARG114 | |
| J | ASN77 | |
| J | HIS83 | |
| J | ASP90 | |
| J | LEU104 | |
| A | ARG114 | |
| J | ARG114 | |
| K | ASN77 | |
| K | HIS83 | |
| K | ASP90 | |
| K | LEU104 | |
| K | ARG114 | |
| L | ASN77 | |
| L | HIS83 | |
| L | ASP90 | |
| L | LEU104 | |
| B | ASN77 | |
| L | ARG114 | |
| B | HIS83 | |
| B | ASP90 | |
| B | LEU104 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | SITE: Transition state stabilizer => ECO:0000255|HAMAP-Rule:MF_00169 |
| Chain | Residue | Details |
| A | ARG21 | |
| J | ARG21 | |
| K | ARG21 | |
| L | ARG21 | |
| B | ARG21 | |
| C | ARG21 | |
| D | ARG21 | |
| E | ARG21 | |
| F | ARG21 | |
| G | ARG21 | |
| H | ARG21 | |
| I | ARG21 |
