6HR7
HMG-CoA reductase from Methanothermococcus thermolithotrophicus apo form at 2.4 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004420 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
| A | 0005778 | cellular_component | peroxisomal membrane |
| A | 0006696 | biological_process | ergosterol biosynthetic process |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0015936 | biological_process | coenzyme A metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004420 | molecular_function | hydroxymethylglutaryl-CoA reductase (NADPH) activity |
| B | 0005778 | cellular_component | peroxisomal membrane |
| B | 0006696 | biological_process | ergosterol biosynthetic process |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0015936 | biological_process | coenzyme A metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 501 |
| Chain | Residue |
| A | MET196 |
| A | GLY197 |
| A | MET198 |
| A | ASN199 |
| A | MET200 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 502 |
| Chain | Residue |
| A | ARG167 |
| A | HIS168 |
| A | GLU353 |
| B | HIS49 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue DTT A 503 |
| Chain | Residue |
| A | ASN90 |
| A | GLU360 |
| A | GLY363 |
| A | LYS372 |
| B | SER43 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue DTT A 504 |
| Chain | Residue |
| A | ILE8 |
| A | HIS401 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue NA A 505 |
| Chain | Residue |
| A | GLU59 |
| A | ARG351 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue GOL A 506 |
| Chain | Residue |
| A | ASP173 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 507 |
| Chain | Residue |
| A | LEU25 |
| A | GLY27 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 508 |
| Chain | Residue |
| A | THR328 |
| A | GLU329 |
| B | LYS137 |
| B | ARG182 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue P6G A 509 |
| Chain | Residue |
| A | GLU10 |
| A | LYS14 |
| B | SER164 |
| B | THR165 |
| B | THR166 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 501 |
| Chain | Residue |
| B | ALA195 |
| B | MET196 |
| B | GLY197 |
| B | MET198 |
| B | ASN199 |
| B | MET200 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 502 |
| Chain | Residue |
| A | ILE142 |
| A | LYS146 |
| B | ARG124 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 503 |
| Chain | Residue |
| B | LYS152 |
| B | PHE155 |
| B | ILE172 |
| B | ASP173 |
| site_id | AD4 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 504 |
| Chain | Residue |
| B | LYS146 |
Functional Information from PROSITE/UniProt
| site_id | PS00066 |
| Number of Residues | 15 |
| Details | HMG_COA_REDUCTASE_1 Hydroxymethylglutaryl-coenzyme A reductases signature 1. RfVYkTGDaMGmNmV |
| Chain | Residue | Details |
| A | ARG187-VAL201 |
| site_id | PS00318 |
| Number of Residues | 8 |
| Details | HMG_COA_REDUCTASE_2 Hydroxymethylglutaryl-coenzyme A reductases signature 2. VGtVGGGT |
| Chain | Residue | Details |
| A | VAL343-THR350 |
