Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6HPP

X-ray structure of GLIC in complex with propionate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue CL A 401

Chain	Residue
A	PHE78

site_id	AC2
Number of Residues	3
Details	binding site for residue CL A 402

Chain	Residue
A	ASN139
A	LEU180
D	ALA175

site_id	AC3
Number of Residues	3
Details	binding site for residue CL A 403

Chain	Residue
A	ALA175
D	ASN139
D	LEU180

site_id	AC4
Number of Residues	3
Details	binding site for residue NA A 404

Chain	Residue
A	ILE73
A	PRO68
A	ILE71

site_id	AC5
Number of Residues	1
Details	binding site for residue NA A 405

Chain	Residue
B	THR226

site_id	AC6
Number of Residues	2
Details	binding site for residue LMT A 406

Chain	Residue
C	LMT403
E	LMT403

site_id	AC7
Number of Residues	5
Details	binding site for residue PPI A 408

Chain	Residue
A	PHE42
A	ARG105
B	ARG77
B	ILE131
B	GLU181

site_id	AC8
Number of Residues	5
Details	binding site for residue PPI A 409

Chain	Residue
A	ARG77
A	ILE131
A	GLU181
E	PHE42
E	ARG105

site_id	AC9
Number of Residues	4
Details	binding site for residue PPI A 410

Chain	Residue
A	ILE73
A	ILE76
A	ARG85
A	TYR102

site_id	AD1
Number of Residues	1
Details	binding site for residue CL B 401

Chain	Residue
B	PHE78

site_id	AD2
Number of Residues	4
Details	binding site for residue NA B 402

Chain	Residue
B	PRO68
B	ILE71
B	TRP72
B	ILE73

site_id	AD3
Number of Residues	2
Details	binding site for residue LMT B 403

Chain	Residue
A	ALA237
B	ALA237

site_id	AD4
Number of Residues	5
Details	binding site for residue PPI B 404

Chain	Residue
B	PHE42
B	ARG105
C	ARG77
C	ILE131
C	GLU181

site_id	AD5
Number of Residues	5
Details	binding site for residue PPI B 405

Chain	Residue
B	PRO74
B	GLU75
B	ILE76
B	ARG85
B	TYR102

site_id	AD6
Number of Residues	1
Details	binding site for residue CL C 401

Chain	Residue
C	PHE78

site_id	AD7
Number of Residues	3
Details	binding site for residue NA C 402

Chain	Residue
C	PRO68
C	ILE71
C	ILE73

site_id	AD8
Number of Residues	2
Details	binding site for residue LMT C 403

Chain	Residue
A	LMT406
C	ILE240

site_id	AD9
Number of Residues	5
Details	binding site for residue PPI C 404

Chain	Residue
C	ILE73
C	PRO74
C	GLU75
C	ILE76
C	ARG85

site_id	AE1
Number of Residues	2
Details	binding site for residue CL D 401

Chain	Residue
D	PHE78
D	ARG85

site_id	AE2
Number of Residues	3
Details	binding site for residue NA D 402

Chain	Residue
D	ILE71
D	TRP72
D	ILE73

site_id	AE3
Number of Residues	1
Details	binding site for residue LMT D 403

Chain	Residue
C	ALA237

site_id	AE4
Number of Residues	5
Details	binding site for residue PPI D 404

Chain	Residue
C	PHE42
C	ARG105
D	ARG77
D	ILE131
D	GLU181

site_id	AE5
Number of Residues	5
Details	binding site for residue PPI D 405

Chain	Residue
D	PHE42
D	ARG105
E	ARG77
E	ILE131
E	GLU181

site_id	AE6
Number of Residues	5
Details	binding site for residue PPI D 406

Chain	Residue
D	PRO74
D	GLU75
D	ILE76
D	ARG85
D	TYR102

site_id	AE7
Number of Residues	2
Details	binding site for residue CL E 401

Chain	Residue
E	PHE78
E	VAL81

site_id	AE8
Number of Residues	3
Details	binding site for residue NA E 402

Chain	Residue
E	PRO68
E	ILE71
E	ILE73

site_id	AE9
Number of Residues	1
Details	binding site for residue LMT E 403

Chain	Residue
A	LMT406

site_id	AF1
Number of Residues	5
Details	binding site for residue PPI E 404

Chain	Residue
E	PRO74
E	ILE76
E	ARG85
E	TYR102
E	GLU104

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	370
Details	Transmembrane: {"description":"Helical"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	20
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	35
Details	Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)