6HNS
Structure of Nitrincola lacisaponensis flavin-containing monooxygenase (FMO) in complex with FAD and NADP+
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016709 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0050661 | molecular_function | NADP binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004497 | molecular_function | monooxygenase activity |
| B | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016709 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 36 |
| Details | binding site for residue FAD A 501 |
| Chain | Residue |
| A | GLY9 |
| A | MET46 |
| A | TRP47 |
| A | HIS63 |
| A | SER65 |
| A | SER72 |
| A | ASN73 |
| A | LEU79 |
| A | THR124 |
| A | ALA125 |
| A | VAL126 |
| A | GLY11 |
| A | ALA161 |
| A | CYS162 |
| A | PHE165 |
| A | GLN318 |
| A | SER321 |
| A | PHE322 |
| A | PHE325 |
| A | NAP502 |
| A | HOH610 |
| A | HOH647 |
| A | PRO12 |
| A | HOH656 |
| A | HOH693 |
| A | HOH706 |
| A | HOH715 |
| A | HOH739 |
| A | HOH746 |
| A | HOH789 |
| A | CYS13 |
| A | PHE37 |
| A | GLU38 |
| A | LYS39 |
| A | GLN40 |
| A | GLY45 |
| site_id | AC2 |
| Number of Residues | 34 |
| Details | binding site for residue NAP A 502 |
| Chain | Residue |
| A | TYR67 |
| A | LEU70 |
| A | TRP71 |
| A | ASN73 |
| A | PHE165 |
| A | ASN169 |
| A | PRO171 |
| A | SER205 |
| A | SER206 |
| A | TYR207 |
| A | SER208 |
| A | ASP211 |
| A | ARG229 |
| A | SER230 |
| A | CYS271 |
| A | THR272 |
| A | GLY273 |
| A | TYR274 |
| A | ASN291 |
| A | ARG412 |
| A | FAD501 |
| A | HOH610 |
| A | HOH613 |
| A | HOH615 |
| A | HOH620 |
| A | HOH626 |
| A | HOH629 |
| A | HOH644 |
| A | HOH660 |
| A | HOH702 |
| A | HOH726 |
| A | HOH727 |
| A | HOH756 |
| A | HOH797 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 503 |
| Chain | Residue |
| A | HOH620 |
| A | HOH702 |
| A | HOH726 |
| A | HOH767 |
| A | HOH832 |
| A | HOH835 |
| site_id | AC4 |
| Number of Residues | 35 |
| Details | binding site for residue FAD B 501 |
| Chain | Residue |
| B | SER321 |
| B | PHE322 |
| B | PHE325 |
| B | NAP502 |
| B | HOH623 |
| B | HOH644 |
| B | HOH648 |
| B | HOH678 |
| B | HOH684 |
| B | HOH717 |
| B | HOH719 |
| B | HOH759 |
| B | GLY9 |
| B | GLY11 |
| B | PRO12 |
| B | CYS13 |
| B | PHE37 |
| B | GLU38 |
| B | LYS39 |
| B | GLN40 |
| B | GLY45 |
| B | MET46 |
| B | TRP47 |
| B | HIS63 |
| B | MET66 |
| B | SER72 |
| B | ASN73 |
| B | LEU79 |
| B | THR124 |
| B | ALA125 |
| B | VAL126 |
| B | ALA161 |
| B | CYS162 |
| B | PHE165 |
| B | GLN318 |
| site_id | AC5 |
| Number of Residues | 31 |
| Details | binding site for residue NAP B 502 |
| Chain | Residue |
| B | TYR67 |
| B | LEU70 |
| B | TRP71 |
| B | ASN73 |
| B | PHE165 |
| B | PRO171 |
| B | SER205 |
| B | SER206 |
| B | TYR207 |
| B | SER208 |
| B | ASP211 |
| B | ARG229 |
| B | SER230 |
| B | CYS271 |
| B | THR272 |
| B | GLY273 |
| B | TYR274 |
| B | ASN291 |
| B | ARG412 |
| B | FAD501 |
| B | HOH606 |
| B | HOH608 |
| B | HOH612 |
| B | HOH634 |
| B | HOH649 |
| B | HOH664 |
| B | HOH671 |
| B | HOH729 |
| B | HOH731 |
| B | HOH743 |
| B | HOH756 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 503 |
| Chain | Residue |
| B | HOH606 |
| B | HOH743 |
| B | HOH756 |
| B | HOH776 |
| B | HOH803 |
| B | HOH817 |
