6HJB
Xray structure of GLIC in complex with malonate
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004888 | molecular_function | transmembrane signaling receptor activity |
A | 0005216 | molecular_function | monoatomic ion channel activity |
A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0016020 | cellular_component | membrane |
A | 0034220 | biological_process | monoatomic ion transmembrane transport |
B | 0004888 | molecular_function | transmembrane signaling receptor activity |
B | 0005216 | molecular_function | monoatomic ion channel activity |
B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
B | 0006811 | biological_process | monoatomic ion transport |
B | 0016020 | cellular_component | membrane |
B | 0034220 | biological_process | monoatomic ion transmembrane transport |
C | 0004888 | molecular_function | transmembrane signaling receptor activity |
C | 0005216 | molecular_function | monoatomic ion channel activity |
C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
C | 0006811 | biological_process | monoatomic ion transport |
C | 0016020 | cellular_component | membrane |
C | 0034220 | biological_process | monoatomic ion transmembrane transport |
D | 0004888 | molecular_function | transmembrane signaling receptor activity |
D | 0005216 | molecular_function | monoatomic ion channel activity |
D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
D | 0006811 | biological_process | monoatomic ion transport |
D | 0016020 | cellular_component | membrane |
D | 0034220 | biological_process | monoatomic ion transmembrane transport |
E | 0004888 | molecular_function | transmembrane signaling receptor activity |
E | 0005216 | molecular_function | monoatomic ion channel activity |
E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
E | 0006811 | biological_process | monoatomic ion transport |
E | 0016020 | cellular_component | membrane |
E | 0034220 | biological_process | monoatomic ion transmembrane transport |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | binding site for residue PLC A 401 |
Chain | Residue |
A | ARG118 |
A | PHE121 |
A | TYR254 |
A | PHE315 |
A | PLC402 |
site_id | AC2 |
Number of Residues | 1 |
Details | binding site for residue PLC A 402 |
Chain | Residue |
A | PLC401 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue CL A 403 |
Chain | Residue |
A | ASN139 |
A | LEU180 |
D | ALA175 |
site_id | AC4 |
Number of Residues | 2 |
Details | binding site for residue NA A 404 |
Chain | Residue |
A | PRO68 |
A | ILE71 |
site_id | AC5 |
Number of Residues | 2 |
Details | binding site for residue LMT A 405 |
Chain | Residue |
A | ILE240 |
A | THR244 |
site_id | AC6 |
Number of Residues | 6 |
Details | binding site for residue MLA A 406 |
Chain | Residue |
A | ARG77 |
A | VAL79 |
A | ILE131 |
A | GLU181 |
E | PHE42 |
E | ARG105 |
site_id | AC7 |
Number of Residues | 2 |
Details | binding site for residue CL A 407 |
Chain | Residue |
A | PRO74 |
A | ARG85 |
site_id | AC8 |
Number of Residues | 2 |
Details | binding site for residue CL A 408 |
Chain | Residue |
A | PHE78 |
A | ARG85 |
site_id | AC9 |
Number of Residues | 1 |
Details | binding site for residue PLC B 401 |
Chain | Residue |
B | PLC407 |
site_id | AD1 |
Number of Residues | 3 |
Details | binding site for residue NA B 402 |
Chain | Residue |
B | PRO68 |
B | ILE71 |
B | ILE73 |
site_id | AD2 |
Number of Residues | 9 |
Details | binding site for residue LMT B 403 |
Chain | Residue |
A | ALA237 |
B | LYS33 |
B | ALA237 |
B | ILE240 |
B | THR244 |
B | ASN245 |
C | LYS33 |
C | THR244 |
E | LMT401 |
site_id | AD3 |
Number of Residues | 2 |
Details | binding site for residue CL B 404 |
Chain | Residue |
B | PRO74 |
B | ARG85 |
site_id | AD4 |
Number of Residues | 2 |
Details | binding site for residue CL B 405 |
Chain | Residue |
B | PHE78 |
B | ARG85 |
site_id | AD5 |
Number of Residues | 8 |
Details | binding site for residue MLA B 406 |
Chain | Residue |
A | ILE25 |
A | PHE42 |
A | ARG105 |
B | ARG77 |
B | VAL79 |
B | ILE131 |
B | LEU176 |
B | GLU181 |
site_id | AD6 |
Number of Residues | 3 |
Details | binding site for residue PLC B 407 |
Chain | Residue |
B | TYR194 |
B | LEU203 |
B | PLC401 |
site_id | AD7 |
Number of Residues | 6 |
Details | binding site for residue PLC C 401 |
Chain | Residue |
C | ARG118 |
C | TYR194 |
C | TYR254 |
C | ASN307 |
C | PHE315 |
C | PLC402 |
site_id | AD8 |
Number of Residues | 1 |
Details | binding site for residue PLC C 402 |
Chain | Residue |
C | PLC401 |
site_id | AD9 |
Number of Residues | 2 |
Details | binding site for residue NA C 403 |
Chain | Residue |
C | PRO68 |
C | ILE71 |
site_id | AE1 |
Number of Residues | 2 |
Details | binding site for residue LMT C 404 |
Chain | Residue |
C | ILE240 |
E | LMT401 |
site_id | AE2 |
Number of Residues | 1 |
Details | binding site for residue CL C 405 |
Chain | Residue |
C | PRO74 |
site_id | AE3 |
Number of Residues | 2 |
Details | binding site for residue CL C 406 |
Chain | Residue |
C | PHE78 |
C | ARG85 |
site_id | AE4 |
Number of Residues | 6 |
Details | binding site for residue MLA C 407 |
Chain | Residue |
B | ILE25 |
B | PHE42 |
B | ARG105 |
C | ARG77 |
C | ILE131 |
C | GLU181 |
site_id | AE5 |
Number of Residues | 1 |
Details | binding site for residue PLC C 408 |
Chain | Residue |
C | MET252 |
site_id | AE6 |
Number of Residues | 6 |
Details | binding site for residue PLC D 401 |
Chain | Residue |
D | ARG118 |
D | TYR194 |
D | TYR254 |
D | ASN307 |
D | PHE315 |
D | PLC402 |
site_id | AE7 |
Number of Residues | 1 |
Details | binding site for residue PLC D 402 |
Chain | Residue |
D | PLC401 |
site_id | AE8 |
Number of Residues | 2 |
Details | binding site for residue NA D 403 |
Chain | Residue |
D | PRO68 |
D | ILE71 |
site_id | AE9 |
Number of Residues | 1 |
Details | binding site for residue LMT D 404 |
Chain | Residue |
D | ALA237 |
site_id | AF1 |
Number of Residues | 2 |
Details | binding site for residue CL D 405 |
Chain | Residue |
D | PRO74 |
D | ARG85 |
site_id | AF2 |
Number of Residues | 2 |
Details | binding site for residue CL D 406 |
Chain | Residue |
D | PHE78 |
D | ARG85 |
site_id | AF3 |
Number of Residues | 6 |
Details | binding site for residue MLA D 407 |
Chain | Residue |
C | PHE42 |
C | ARG105 |
D | ARG77 |
D | VAL79 |
D | ILE131 |
D | GLU181 |
site_id | AF4 |
Number of Residues | 2 |
Details | binding site for residue NA D 408 |
Chain | Residue |
A | ASP178 |
D | GLU177 |
site_id | AF5 |
Number of Residues | 3 |
Details | binding site for residue LMT E 401 |
Chain | Residue |
B | LMT403 |
C | LMT404 |
E | LMT405 |
site_id | AF6 |
Number of Residues | 8 |
Details | binding site for residue PLC E 402 |
Chain | Residue |
E | TYR194 |
E | ILE198 |
E | TYR254 |
E | ASN307 |
E | PHE315 |
E | PLC403 |
E | ARG118 |
E | PHE121 |
site_id | AF7 |
Number of Residues | 1 |
Details | binding site for residue PLC E 403 |
Chain | Residue |
E | PLC402 |
site_id | AF8 |
Number of Residues | 2 |
Details | binding site for residue NA E 404 |
Chain | Residue |
E | PRO68 |
E | ILE71 |
site_id | AF9 |
Number of Residues | 2 |
Details | binding site for residue LMT E 405 |
Chain | Residue |
E | ALA237 |
E | LMT401 |
site_id | AG1 |
Number of Residues | 2 |
Details | binding site for residue CL E 406 |
Chain | Residue |
E | PRO74 |
E | ARG85 |
site_id | AG2 |
Number of Residues | 2 |
Details | binding site for residue CL E 407 |
Chain | Residue |
E | PHE78 |
E | ARG85 |
site_id | AG3 |
Number of Residues | 6 |
Details | binding site for residue MLA E 408 |
Chain | Residue |
D | ILE25 |
D | PHE42 |
D | ARG105 |
E | ARG77 |
E | ILE131 |
E | GLU181 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 990 |
Details | TOPO_DOM: Periplasmic => ECO:0000255 |
Chain | Residue | Details |
A | GLN2-GLN193 | |
E | ASN245-MET252 | |
A | ASN245-MET252 | |
B | GLN2-GLN193 | |
B | ASN245-MET252 | |
C | GLN2-GLN193 | |
C | ASN245-MET252 | |
D | GLN2-GLN193 | |
D | ASN245-MET252 | |
E | GLN2-GLN193 |
site_id | SWS_FT_FI2 |
Number of Residues | 530 |
Details | TRANSMEM: Helical |
Chain | Residue | Details |
A | TYR194-PHE216 | |
C | SER220-THR244 | |
C | THR253-VAL281 | |
C | PRO285-PHE317 | |
D | TYR194-PHE216 | |
D | SER220-THR244 | |
D | THR253-VAL281 | |
D | PRO285-PHE317 | |
E | TYR194-PHE216 | |
E | SER220-THR244 | |
E | THR253-VAL281 | |
A | SER220-THR244 | |
E | PRO285-PHE317 | |
A | THR253-VAL281 | |
A | PRO285-PHE317 | |
B | TYR194-PHE216 | |
B | SER220-THR244 | |
B | THR253-VAL281 | |
B | PRO285-PHE317 | |
C | TYR194-PHE216 |
site_id | SWS_FT_FI3 |
Number of Residues | 20 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
Chain | Residue | Details |
A | TRP217-THR219 | |
E | GLU282-GLN284 | |
A | GLU282-GLN284 | |
B | TRP217-THR219 | |
B | GLU282-GLN284 | |
C | TRP217-THR219 | |
C | GLU282-GLN284 | |
D | TRP217-THR219 | |
D | GLU282-GLN284 | |
E | TRP217-THR219 |