Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6HJ3

Xray structure of GLIC in complex with fumarate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue PLC A 401

Chain	Residue
A	PHE121
A	TYR254
A	ASN307
A	PHE315
A	PLC403

site_id	AC2
Number of Residues	5
Details	binding site for residue PLC A 402

Chain	Residue
B	TYR278
A	PHE210
A	TRP213
A	TRP217
B	PHE267

site_id	AC3
Number of Residues	1
Details	binding site for residue PLC A 403

Chain	Residue
A	PLC401

site_id	AC4
Number of Residues	2
Details	binding site for residue CL A 404

Chain	Residue
A	PHE78
A	ARG85

site_id	AC5
Number of Residues	3
Details	binding site for residue CL A 405

Chain	Residue
A	ASN139
A	LEU180
D	ALA175

site_id	AC6
Number of Residues	3
Details	binding site for residue CL A 406

Chain	Residue
A	ALA175
D	ASN139
D	LEU180

site_id	AC7
Number of Residues	3
Details	binding site for residue NA A 407

Chain	Residue
A	PRO68
A	ILE71
A	ILE73

site_id	AC8
Number of Residues	3
Details	binding site for residue LMT A 408

Chain	Residue
A	THR244
D	LMT401
E	ALA237

site_id	AC9
Number of Residues	2
Details	binding site for residue PLC A 409

Chain	Residue
A	VAL275
E	TRP217

site_id	AD1
Number of Residues	2
Details	binding site for residue CL A 410

Chain	Residue
A	PRO74
A	ARG85

site_id	AD2
Number of Residues	9
Details	binding site for residue FUM A 411

Chain	Residue
A	ARG77
A	ILE131
A	PHE174
A	LEU176
A	GLU181
E	ILE25
E	PHE42
E	ARG105
E	ASN152

site_id	AD3
Number of Residues	9
Details	binding site for residue FUM A 412

Chain	Residue
A	ILE25
A	PHE42
A	ARG105
A	ASN152
B	ARG77
B	ILE131
B	PHE174
B	LEU176
B	GLU181

site_id	AD4
Number of Residues	2
Details	binding site for residue NA B 401

Chain	Residue
A	HOH501
C	THR226

site_id	AD5
Number of Residues	6
Details	binding site for residue PLC B 402

Chain	Residue
B	ARG118
B	PHE121
B	TYR254
B	ASN307
B	PHE315
B	PLC404

site_id	AD6
Number of Residues	3
Details	binding site for residue PLC B 403

Chain	Residue
B	TRP213
B	THR214
C	TYR278

site_id	AD7
Number of Residues	1
Details	binding site for residue PLC B 404

Chain	Residue
B	PLC402

site_id	AD8
Number of Residues	2
Details	binding site for residue CL B 405

Chain	Residue
B	PHE78
B	ARG85

site_id	AD9
Number of Residues	3
Details	binding site for residue NA B 406

Chain	Residue
B	PRO68
B	ILE71
B	ILE73

site_id	AE1
Number of Residues	1
Details	binding site for residue LMT B 407

Chain	Residue
B	ALA237

site_id	AE2
Number of Residues	2
Details	binding site for residue CL B 408

Chain	Residue
B	PRO74
B	ARG85

site_id	AE3
Number of Residues	7
Details	binding site for residue PLC C 401

Chain	Residue
C	ARG118
C	PHE121
C	TYR194
C	TYR254
C	ASN307
C	PHE315
C	PLC403

site_id	AE4
Number of Residues	3
Details	binding site for residue PLC C 402

Chain	Residue
C	TRP217
D	VAL275
D	TYR278

site_id	AE5
Number of Residues	1
Details	binding site for residue PLC C 403

Chain	Residue
C	PLC401

site_id	AE6
Number of Residues	2
Details	binding site for residue CL C 404

Chain	Residue
C	PHE78
C	ARG85

site_id	AE7
Number of Residues	3
Details	binding site for residue NA C 405

Chain	Residue
C	PRO68
C	ILE71
C	ILE73

site_id	AE8
Number of Residues	3
Details	binding site for residue LMT C 406

Chain	Residue
B	ALA237
C	ILE240
D	LMT401

site_id	AE9
Number of Residues	9
Details	binding site for residue FUM C 407

Chain	Residue
B	ILE25
B	PHE42
B	ARG105
B	ASN152
C	ARG77
C	ILE131
C	PHE174
C	LEU176
C	GLU181

site_id	AF1
Number of Residues	2
Details	binding site for residue CL C 408

Chain	Residue
C	PRO74
C	ARG85

site_id	AF2
Number of Residues	2
Details	binding site for residue LMT D 401

Chain	Residue
A	LMT408
C	LMT406

site_id	AF3
Number of Residues	5
Details	binding site for residue PLC D 402

Chain	Residue
D	ARG118
D	PHE121
D	TYR194
D	TYR254
D	ASN307

site_id	AF4
Number of Residues	2
Details	binding site for residue CL D 404

Chain	Residue
D	PHE78
D	ARG85

site_id	AF5
Number of Residues	3
Details	binding site for residue NA D 405

Chain	Residue
D	PRO68
D	ILE71
D	ILE73

site_id	AF6
Number of Residues	2
Details	binding site for residue LMT D 406

Chain	Residue
D	ALA237
D	THR244

site_id	AF7
Number of Residues	9
Details	binding site for residue FUM D 407

Chain	Residue
C	ILE25
C	PHE42
C	ARG105
C	ASN152
D	ARG77
D	ILE131
D	PHE174
D	LEU176
D	GLU181

site_id	AF8
Number of Residues	2
Details	binding site for residue CL D 408

Chain	Residue
D	PRO74
D	ARG85

site_id	AF9
Number of Residues	2
Details	binding site for residue PLC E 401

Chain	Residue
D	TRP217
E	TYR278

site_id	AG1
Number of Residues	6
Details	binding site for residue PLC E 402

Chain	Residue
E	ARG118
E	PHE121
E	TYR194
E	TYR254
E	ASN307
E	PHE315

site_id	AG2
Number of Residues	2
Details	binding site for residue CL E 404

Chain	Residue
E	PHE78
E	ARG85

site_id	AG3
Number of Residues	2
Details	binding site for residue NA E 405

Chain	Residue
E	PRO68
E	ILE71

site_id	AG4
Number of Residues	1
Details	binding site for residue LMT E 406

Chain	Residue
E	THR244

site_id	AG5
Number of Residues	2
Details	binding site for residue CL E 407

Chain	Residue
E	PRO74
E	ARG85

site_id	AG6
Number of Residues	9
Details	binding site for residue FUM E 408

Chain	Residue
D	ILE25
D	PHE42
D	ARG105
D	ASN152
E	ARG77
E	ILE131
E	PHE174
E	LEU176
E	GLU181

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	370
Details	Transmembrane: {"description":"Helical"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	20
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	35
Details	Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)