Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6HIT

The crystal structure of haemoglobin from Atlantic cod

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0005344	molecular_function	oxygen carrier activity
A	0005506	molecular_function	iron ion binding
A	0005833	cellular_component	hemoglobin complex
A	0015671	biological_process	oxygen transport
A	0019825	molecular_function	oxygen binding
A	0020037	molecular_function	heme binding
A	0031720	molecular_function	haptoglobin binding
A	0031838	cellular_component	haptoglobin-hemoglobin complex
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0043177	molecular_function	organic acid binding
A	0046872	molecular_function	metal ion binding
A	0072562	cellular_component	blood microparticle
A	0098869	biological_process	cellular oxidant detoxification
B	0004601	molecular_function	peroxidase activity
B	0005344	molecular_function	oxygen carrier activity
B	0005833	cellular_component	hemoglobin complex
B	0015671	biological_process	oxygen transport
B	0019825	molecular_function	oxygen binding
B	0020037	molecular_function	heme binding
B	0031720	molecular_function	haptoglobin binding
B	0031838	cellular_component	haptoglobin-hemoglobin complex
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0043177	molecular_function	organic acid binding
B	0046872	molecular_function	metal ion binding
B	0072562	cellular_component	blood microparticle
B	0098869	biological_process	cellular oxidant detoxification
C	0004601	molecular_function	peroxidase activity
C	0005344	molecular_function	oxygen carrier activity
C	0005506	molecular_function	iron ion binding
C	0005833	cellular_component	hemoglobin complex
C	0015671	biological_process	oxygen transport
C	0019825	molecular_function	oxygen binding
C	0020037	molecular_function	heme binding
C	0031720	molecular_function	haptoglobin binding
C	0031838	cellular_component	haptoglobin-hemoglobin complex
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0043177	molecular_function	organic acid binding
C	0046872	molecular_function	metal ion binding
C	0072562	cellular_component	blood microparticle
C	0098869	biological_process	cellular oxidant detoxification
D	0004601	molecular_function	peroxidase activity
D	0005344	molecular_function	oxygen carrier activity
D	0005833	cellular_component	hemoglobin complex
D	0015671	biological_process	oxygen transport
D	0019825	molecular_function	oxygen binding
D	0020037	molecular_function	heme binding
D	0031720	molecular_function	haptoglobin binding
D	0031838	cellular_component	haptoglobin-hemoglobin complex
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0043177	molecular_function	organic acid binding
D	0046872	molecular_function	metal ion binding
D	0072562	cellular_component	blood microparticle
D	0098869	biological_process	cellular oxidant detoxification
E	0004601	molecular_function	peroxidase activity
E	0005344	molecular_function	oxygen carrier activity
E	0005506	molecular_function	iron ion binding
E	0005833	cellular_component	hemoglobin complex
E	0015671	biological_process	oxygen transport
E	0019825	molecular_function	oxygen binding
E	0020037	molecular_function	heme binding
E	0031720	molecular_function	haptoglobin binding
E	0031838	cellular_component	haptoglobin-hemoglobin complex
E	0042744	biological_process	hydrogen peroxide catabolic process
E	0043177	molecular_function	organic acid binding
E	0046872	molecular_function	metal ion binding
E	0072562	cellular_component	blood microparticle
E	0098869	biological_process	cellular oxidant detoxification
F	0004601	molecular_function	peroxidase activity
F	0005344	molecular_function	oxygen carrier activity
F	0005833	cellular_component	hemoglobin complex
F	0015671	biological_process	oxygen transport
F	0019825	molecular_function	oxygen binding
F	0020037	molecular_function	heme binding
F	0031720	molecular_function	haptoglobin binding
F	0031838	cellular_component	haptoglobin-hemoglobin complex
F	0042744	biological_process	hydrogen peroxide catabolic process
F	0043177	molecular_function	organic acid binding
F	0046872	molecular_function	metal ion binding
F	0072562	cellular_component	blood microparticle
F	0098869	biological_process	cellular oxidant detoxification
G	0004601	molecular_function	peroxidase activity
G	0005344	molecular_function	oxygen carrier activity
G	0005506	molecular_function	iron ion binding
G	0005833	cellular_component	hemoglobin complex
G	0015671	biological_process	oxygen transport
G	0019825	molecular_function	oxygen binding
G	0020037	molecular_function	heme binding
G	0031720	molecular_function	haptoglobin binding
G	0031838	cellular_component	haptoglobin-hemoglobin complex
G	0042744	biological_process	hydrogen peroxide catabolic process
G	0043177	molecular_function	organic acid binding
G	0046872	molecular_function	metal ion binding
G	0072562	cellular_component	blood microparticle
G	0098869	biological_process	cellular oxidant detoxification
H	0004601	molecular_function	peroxidase activity
H	0005344	molecular_function	oxygen carrier activity
H	0005833	cellular_component	hemoglobin complex
H	0015671	biological_process	oxygen transport
H	0019825	molecular_function	oxygen binding
H	0020037	molecular_function	heme binding
H	0031720	molecular_function	haptoglobin binding
H	0031838	cellular_component	haptoglobin-hemoglobin complex
H	0042744	biological_process	hydrogen peroxide catabolic process
H	0043177	molecular_function	organic acid binding
H	0046872	molecular_function	metal ion binding
H	0072562	cellular_component	blood microparticle
H	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue HEM A 201

Chain	Residue
A	TYR43
A	PHE44
A	HIS46
A	HIS60
A	THR63
A	LEU85
A	HIS89
A	LEU93
A	LEU103

site_id	AC2
Number of Residues	12
Details	binding site for residue HEM B 201

Chain	Residue
B	TYR42
B	PHE43
B	PHE46
B	HIS64
B	LYS67
B	LEU92
B	HIS93
B	LEU97
B	VAL99
B	ASN103
B	PHE104
B	LEU142

site_id	AC3
Number of Residues	11
Details	binding site for residue HEM C 201

Chain	Residue
C	TYR43
C	HIS46
C	TRP47
C	HIS60
C	THR63
C	HIS89
C	LEU93
C	ASN99
C	PHE100
C	LEU103
C	LEU134

site_id	AC4
Number of Residues	12
Details	binding site for residue HEM D 201

Chain	Residue
D	TYR42
D	PHE43
D	HIS64
D	ILE68
D	LEU72
D	LEU89
D	LEU92
D	HIS93
D	LEU97
D	ASN103
D	PHE104
D	LEU142

site_id	AC5
Number of Residues	12
Details	binding site for residue HEM E 201

Chain	Residue
E	PHE44
E	HIS46
E	HIS60
E	THR63
E	LEU88
E	HIS89
E	LEU93
E	VAL95
E	ASN99
E	PHE100
E	LEU103
E	LEU134

site_id	AC6
Number of Residues	11
Details	binding site for residue HEM F 201

Chain	Residue
F	TYR42
F	PHE43
F	HIS64
F	LEU72
F	LEU92
F	HIS93
F	LEU97
F	ASN103
F	PHE104
F	LEU107
F	LEU142

site_id	AC7
Number of Residues	13
Details	binding site for residue HEM G 201

Chain	Residue
B	PRO59
G	TYR43
G	PHE44
G	HIS46
G	TRP47
G	HIS60
G	THR63
G	ILE64
G	HIS89
G	LEU93
G	PHE100
G	LEU103
G	LEU134

site_id	AC8
Number of Residues	10
Details	binding site for residue HEM H 201

Chain	Residue
H	TYR42
H	PHE43
H	HIS64
H	ILE68
H	LEU72
H	HIS93
H	LEU97
H	ASN103
H	LEU107
H	LEU142

site_id	AC9
Number of Residues	4
Details	binding site for Di-peptide ACE C 1 and SER C 2

Chain	Residue
A	GLU140
C	LEU3
C	LYS129
C	GLN133

site_id	AD1
Number of Residues	4
Details	binding site for Di-peptide ACE G 1 and SER G 2

Chain	Residue
E	GLU140
G	LEU3
G	LYS129
G	GLN133

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00238

Chain	Residue	Details
A	HIS60
C	HIS60
E	HIS60
G	HIS60

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: proximal binding residue => ECO:0000255\|PROSITE-ProRule:PRU00238

Chain	Residue	Details
A	HIS89
C	HIS89
E	HIS89
G	HIS89

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N-acetylserine => ECO:0000269\|PubMed:16717098

Chain	Residue	Details
A	SER2
C	SER2
E	SER2
G	SER2

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)