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6HIS

Mouse serotonin 5-HT3 receptor, tropisetron-bound, T conformation

Functional Information from GO Data
ChainGOidnamespacecontents
A0004888molecular_functiontransmembrane signaling receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0006811biological_processmonoatomic ion transport
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0016020cellular_componentmembrane
A0034220biological_processmonoatomic ion transmembrane transport
A0045211cellular_componentpostsynaptic membrane
B0004888molecular_functiontransmembrane signaling receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0006811biological_processmonoatomic ion transport
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0016020cellular_componentmembrane
B0034220biological_processmonoatomic ion transmembrane transport
B0045211cellular_componentpostsynaptic membrane
C0004888molecular_functiontransmembrane signaling receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0006811biological_processmonoatomic ion transport
C0015276molecular_functionligand-gated monoatomic ion channel activity
C0016020cellular_componentmembrane
C0034220biological_processmonoatomic ion transmembrane transport
C0045211cellular_componentpostsynaptic membrane
D0004888molecular_functiontransmembrane signaling receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0006811biological_processmonoatomic ion transport
D0015276molecular_functionligand-gated monoatomic ion channel activity
D0016020cellular_componentmembrane
D0034220biological_processmonoatomic ion transmembrane transport
D0045211cellular_componentpostsynaptic membrane
E0004888molecular_functiontransmembrane signaling receptor activity
E0005216molecular_functionmonoatomic ion channel activity
E0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
E0006811biological_processmonoatomic ion transport
E0015276molecular_functionligand-gated monoatomic ion channel activity
E0016020cellular_componentmembrane
E0034220biological_processmonoatomic ion transmembrane transport
E0045211cellular_componentpostsynaptic membrane
Functional Information from PROSITE/UniProt
site_idPS00236
Number of Residues15
DetailsNEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CsLdIynFPfDvqnC
ChainResidueDetails
ACYS135-CYS149

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues130
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
ALEU221-ASP247
ELEU221-ASP247
BLEU221-ASP247
CLEU221-ASP247
DLEU221-ASP247

site_idSWS_FT_FI2
Number of Residues715
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:25119048
ChainResidueDetails
ASER248-VAL252
DGLU300-ARG439
AGLU300-ARG439
ESER248-VAL252
EGLU300-ARG439
BSER248-VAL252
BGLU300-ARG439
CSER248-VAL252
CGLU300-ARG439
DSER248-VAL252

site_idSWS_FT_FI3
Number of Residues90
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
ASER253-ASP271
ESER253-ASP271
BSER253-ASP271
CSER253-ASP271
DSER253-ASP271

site_idSWS_FT_FI4
Number of Residues45
DetailsTOPO_DOM: Extracellular => ECO:0000305|PubMed:25119048
ChainResidueDetails
ATHR272-PRO281
ETHR272-PRO281
BTHR272-PRO281
CTHR272-PRO281
DTHR272-PRO281

site_idSWS_FT_FI5
Number of Residues90
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
APRO281-ALA299
EPRO281-ALA299
BPRO281-ALA299
CPRO281-ALA299
DPRO281-ALA299

site_idSWS_FT_FI6
Number of Residues15
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AVAL83
CVAL83
CCYS149
CILE165
DVAL83
DCYS149
DILE165
ACYS149
AILE165
EVAL83
ECYS149
EILE165
BVAL83
BCYS149
BILE165

227344

PDB entries from 2024-11-13

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